The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Loss of Suppressor T Cells in Active Multiple Sclerosis: Analysis with Monoclonal Antibodies
Abstract
To determine whether abnormalities of immunoregulatory T cells are associated with multiple sclerosis (MS), we characterized peripheral lymphocytes in 33 patients with untreated MS and compared them with 42 normal persons and 29 age-matched control subjects who had other neurologic diseases. For this analysis, we used monoclonal antibodies to the surface antigens of helper (T4) and suppressor (T5) T-cell subsets and to a common T-cell antigen (T3). In contract to normal persons and the controls with other neurologic diseases, the patients with MS had a reduced percentage of T3-positive (T3+) cells (P less than 0.05). More importantly, there was a selective decrease in T5-positive (T5+) cells in 11 of 15 patients with active MS, but in only one of 18 patients with inactive MS and in none of the normal persons or controls with neurologic disease (P less than 0.00001). Serial analysis of five patients with MS showed a correlation between the absence of the T5+ subset and disease activity. Thus, there is loss of peripheral suppressor cells in many patients with active MS, suggesting that immunoregulatory abnormalities contribute to the pathogenesis of the disease.
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Cites
Reinherz, E. L., Kung, P. C., Goldstein, G., & Schlossman, S. F. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.124.3.1301 · Cited by 691
Self-citationReinherz, E. L., Kung, P. C., Pesando, J. M., Ritz, J., Goldstein, G., & Schlossman, S. F. (1979) · The Journal of experimental medicine · doi:10.1084/jem.150.6.1472 · Cited by 574
Self-citationSuppressor cell function in multiple sclerosis: Correlation with clinical disease activity
Antel, J. P., Arnason, B. G. W., & Medof, M. E. (1979) · Annals of Neurology · doi:10.1002/ana.410050406 · Cited by 255
The morbid anatomy of the demyelinative diseases
Adams, R. D., & Kubik, C. S. (1952) · The American Journal of Medicine · doi:10.1016/0002-9343(52)90234-9 · Cited by 245
Abnormalities of Immunoregulatory T Cells in Disorders of Immune Function
Reinherz, E. L., Rubinstein, A., Geha, R. S., Strelkauskas, A. J., Rosen, F. S., & Schlossman, S. F. (1979) · New England Journal of Medicine · doi:10.1056/nejm197911083011902 · Cited by 213
Self-citationKabat, E. A., Freedman, D. A., Murray, J. P., & Knaub, V. (1950) · The American Journal of the Medical Sciences · doi:10.1097/00000441-195001000-00009 · Cited by 186
Antibodies to Oligodendroglia in Patients with Multiple Sclerosis
Abramsky, O., Lisak, R. P., Silberberg, D. H., Pleasure, D., & George, J. (1977) · New England Journal of Medicine · doi:10.1056/nejm197712012972204 · Cited by 156
Multiple sclerosis: Diagnostic usefulness of cerebrospinal fluid
Johnson, K. P., & Nelson, B. J. (1977) · Annals of Neurology · doi:10.1002/ana.410020515 · Cited by 114
Kuwert, E. K., & Bertrams, J. (2008) · European Neurology · doi:10.1159/000114413 · Cited by 62
Opelz, G., Terasaki, P. I., Myers, L. W., Ellison, G. W., Ebers, G. C., Zabriskie, J. B., Weiner, H. L., Kempe, H., & Sibley, W. (1977) · Tissue Antigens · doi:10.1111/j.1399-0039.1977.tb01080.x · Cited by 44
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Cited by
Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions
Hauser, S. L., Bhan, A. K., Gilles, F., Kemp, M., Kerr, C., & Weiner, H. L. (1986) · Annals of Neurology · doi:10.1002/ana.410190610 · Cited by 399
Self-citationHafler, D. A., Fox, D. A., Manning, M. E., Schlossman, S. F., Reinherz, E. L., & Weiner, H. L. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505303122201 · Cited by 304
Self-citationAntibrain antibodies in multiple sclerosis
Ryberg, B. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90185-x · Cited by 23
Metadata
- Authors
- Reinherz, E. L., Weiner, H. L., Hauser, S. L., Cohen, J. A., Distaso, J. A., & Schlossman, S. F.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-07-17
- Volume
- 303
- Issue
- 3
- Pages
- 125-129
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2334399547
- Cited by
- 444
- References
- 12
- FWCI
- 64.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reinherz, E. L., Weiner, H. L., Hauser, S. L., Cohen, J. A., Distaso, J. A., & Schlossman, S. F. (1980). Loss of Suppressor T Cells in Active Multiple Sclerosis: Analysis with Monoclonal Antibodies. New England Journal of Medicine. https://doi.org/10.1056/nejm198007173030303
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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