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The Macrophage as an Effector Cell
Abstract
IT has only been a decade since the "mononuclear phagocyte system" was defined, linking monoblasts, promonocytes, monocytes, and the structurally heterogeneous tissue macrophages. Cells of this lineage develop over several days in the marrow, emigrate from the blood within hours to days, and survive for months in the tissues, where they are involved in important homeostatic mechanisms as well as diverse pathologic events. For 70 years, investigators followed the lead of Metchnikoff, focusing on phagocytosis and the intracellular digestion of particles by macrophages. In the past few years, it has emerged that the macrophage is also a secretory cell. Through . . .
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Citations
Cited by
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
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Lewis, C., & Murdoch, C. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62038-x · Cited by 413
In vivo and in vitro degradation of glycine/DL‐lactic acid copolymers
Schakenraad, J. M., Nieuwenhuis, P., Molenaar, I., Helder, J., Dijkstra, P. J., & Feijen, J. (1989) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820231105 · Cited by 101
Polymorphonuclear leukocyte dysfunction during influenza virus infection in chinchillas.
Abramson, J. S., Giebink, G. S., Mills, E. L., & Quie, P. G. (1981) · Journal of Infectious Diseases · doi:10.1093/infdis/143.6.836 · Cited by 88
Phospholipase Cγ2 Is Essential for Specific Functions of FcεR and FcγR
Wen, R., Jou, S.-T., Chen, Y., Hoffmeyer, A., & Wang, D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.6743 · Cited by 71
Metadata
- Authors
- Nathan, C. F., Murray, H. W., & Cohn, Z. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-09-11
- Volume
- 303
- Issue
- 11
- Pages
- 622-626
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2076940976
- Cited by
- 621
- References
- 0
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Macrophage as an Effector Cell. https://app.cochat.ai/papers/10.1056/nejm198009113031106
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- Nathan, C. F., Murray, H. W., & Cohn, Z. A. (1980). The Macrophage as an Effector Cell. New England Journal of Medicine. https://doi.org/10.1056/nejm198009113031106
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
