Cited by 88Influenza Virus Research StudiesNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune Response and Inflammation

Polymorphonuclear leukocyte dysfunction during influenza virus infection in chinchillas.

Abramson, J. S., Giebink, G. S., Mills, E. L., Quie, P. G.·1981·Journal of Infectious Diseases

Abstract

The increased susceptibility of chinchillas after intranasal inoculation of Streptococcus pneumoniae and influenza A virus to pneumococcal otitis media prompted a study to determine whether infection with influenza virus adversely affects polymorphonuclear leukocyte (PMNL) function and thereby impairs host defense. Thirty-four chinchillas were inoculated intranasally with either influenza A virus or sterile saline. The chemotactic, chemiluminescent, and bactericidal activities of the PMNLs were depressed four to eight days after inoculation of the virus compared with the values obtained before inoculation; these activities remained normal in animals inoculated with sterile saline. The maximum reduction in chemotaxis (37%), peak chemiluminescence (53%), and peak bactericidal activity (26%) of the PMNLs was observed on day 6. Phagocytosis remained normal throughout the period after inoculation. Thus, the susceptibility of chinchillas to pneumococcal disease after inoculation with influenza A virus may be due to the impaired chemotactic and oxidative microbicidal activities of PMNLs.

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Crossref · 10.1093/infdis/143.6.836

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42 of 42 references verified0 citation errors · 0 not checkable

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  • Impaired neutrophils correlate with secondary bacterial infection in chinchillas, due to the importance of phagocytosis during innate immunity.

    “Impaired neutrophils have been shown to correlate with secondary bacterial infection in Chinchillas, due to the importance of phagocytosis during innate immunity (Abramson et al., 1981).”

    From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Abramson et al., 1981

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Authors
Abramson, J. S., Giebink, G. S., Mills, E. L., & Quie, P. G.
Affiliations
University of Minnesota (US)
Corresponding author
Abramson, J. S.
Venue
Journal of Infectious Diseases
Published
1981-06-01
Volume
143
Issue
6
Pages
836-845
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
OpenAlex
W2169998037
Cited by
88
References
42
Citations by year
2024: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 5 · 2013: 2 · 2012: 1
FWCI
8.01
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
influenza A virus, polymorphonuclear leukocytes, neutrophil dysfunction, Streptococcus pneumoniae, pneumococcal otitis media, chemotaxis, chemiluminescence, bactericidal activity, phagocytosis, host defense, chinchilla, secondary infection susceptibility
MeSH terms
Animals, Blood Bactericidal Activity, Chemotaxis, Leukocyte, Chinchilla, Complement Fixation Tests, Luminescent Measurements, Nasopharynx, Neutrophils, Orthomyxoviridae Infections, Influenza A virus, Phagocytosis

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