Polymorphonuclear leukocyte dysfunction during influenza virus infection in chinchillas.
Abstract
The increased susceptibility of chinchillas after intranasal inoculation of Streptococcus pneumoniae and influenza A virus to pneumococcal otitis media prompted a study to determine whether infection with influenza virus adversely affects polymorphonuclear leukocyte (PMNL) function and thereby impairs host defense. Thirty-four chinchillas were inoculated intranasally with either influenza A virus or sterile saline. The chemotactic, chemiluminescent, and bactericidal activities of the PMNLs were depressed four to eight days after inoculation of the virus compared with the values obtained before inoculation; these activities remained normal in animals inoculated with sterile saline. The maximum reduction in chemotaxis (37%), peak chemiluminescence (53%), and peak bactericidal activity (26%) of the PMNLs was observed on day 6. Phagocytosis remained normal throughout the period after inoculation. Thus, the susceptibility of chinchillas to pneumococcal disease after inoculation with influenza A virus may be due to the impaired chemotactic and oxidative microbicidal activities of PMNLs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Impaired neutrophils correlate with secondary bacterial infection in chinchillas, due to the importance of phagocytosis during innate immunity.
“Impaired neutrophils have been shown to correlate with secondary bacterial infection in Chinchillas, due to the importance of phagocytosis during innate immunity (Abramson et al., 1981).”
From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Abramson et al., 1981
Cites
Nelson, R. D., Quie, P. G., & Simmons, R. L. (1975) · The Journal of Immunology · doi:10.4049/jimmunol.115.6.1650 · Cited by 1,178 · see citing works
Self-citationQuie, P. G., White, J. G., Holmes, B. M., & Good, R. A. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105568 · Cited by 906 · see citing works
Self-citationRespiratory-Syncytial-Virus Infections, Reinfections and Immunity
Henderson, F. W., Collier, A. M., Clyde, W. A., & Denny, F. W. (1979) · New England Journal of Medicine · doi:10.1056/nejm197903083001004 · Cited by 705 · see citing works
The Cytomegaloviruses: Ubiquitous Agents with Protean Clinical Manifestations
Weller, T. H. (1971) · New England Journal of Medicine · doi:10.1056/nejm197107292850507 · Cited by 651 · see citing works
The Macrophage as an Effector Cell
Nathan, C., Murray, H. W., & Cohn, Z. A. (1980) · New England Journal of Medicine · doi:10.1056/nejm198009113031106 · Cited by 624 · see citing works
Rand, K. H., Pollard, R. B., & Merigan, T. C. (1978) · New England Journal of Medicine · doi:10.1056/nejm197804272981705 · Cited by 236 · see citing works
Clinicopathologic Study of Thirty-Three Fatal Cases of Asian Influenza
Oseasohn, R., Adelson, L., & Kaji, M. (1959) · New England Journal of Medicine · doi:10.1056/nejm195903122601101 · Cited by 216 · see citing works
A Simultaneous Outbreak of Meningococcal and Influenza Infections
Young, L. S., LaForce, F. M., Head, J. J., FEELEY, J. C., & Bennett, J. V. (1972) · New England Journal of Medicine · doi:10.1056/nejm197207062870102 · Cited by 192 · see citing works
Giebink, G. S., Foker, J. E., Kim, Y., et al. (1980) · The Journal of Infectious Diseases · doi:10.1093/infdis/141.3.404 · Cited by 112 · see citing works
Self-citationWarshauer, D., Goldstein, E., Akers, T., Lippert, W. E., & Kim, M. (1977) · PubMed · doi:10.1164/arrd.1977.115.2.269 · Cited by 95 · see citing works
INFLUENZA AND THE INTERACTION OF VIRUSES AND BACTERIA IN RESPIRATORY INFECTIONS
Loosli, C. G. (1973) · Medicine · doi:10.1097/00005792-197309000-00001 · Cited by 89 · see citing works
Jakab, G. J., & Green, G. M. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108423 · Cited by 83 · see citing works
Interaction of Influenza Virus with Leukocytes and Its Effect on Phagocytosis
Sawyer, W. D. (1969) · The Journal of Infectious Diseases · doi:10.1093/infdis/119.6.541 · Cited by 80 · see citing works
Otitis Media With Effusion: Cytological and Microbiological Correlates
LIM, D. J., Lewis, D. M., Schram, J. L., et al. (1979) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1979.00790190030006 · Cited by 79 · see citing works
Initiation of the respiratory burst of human neutrophils by influenza virus
Mills, E. L., Debets-Ossenkopp, Y. J., Verbrugh, H. A., & Verhoef, J. (1981) · Infection and Immunity · doi:10.1128/iai.32.3.1200-1205.1981 · Cited by 73 · see citing works
Self-citationAlveolar Macrophage Ingestion and Phagosome-Lysosome Fusion Defect Associated with Virus Pneumonia
Jakab, G. J., Warr, G. A., & Sannes, P. L. (1980) · Infection and Immunity · doi:10.1128/iai.27.3.960-968.1980 · Cited by 71 · see citing works
Sellers, T. F., Schulman, J. L., Bouvier, C. A., McCune, R. M., & Kilbourne, E. D. (1961) · The Journal of Experimental Medicine · doi:10.1084/jem.114.2.237 · Cited by 60 · see citing works
COMBINED INFECTIONS IN MICE WITH INFLUENZA VIRUS AND DIPLOCOCCUS PNEUMONIAE
Gerone, P. J., Ward, T. G., & CHAPPAL, W. A. (1957) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a119906 · Cited by 60 · see citing works
Ed, S., & Gg, J. (1966) · PubMed · Cited by 60 · see citing works
Mills, E. L., Rholl, K. S., & Quie, P. G. (1980) · Journal of Clinical Microbiology · doi:10.1128/jcm.12.1.52-56.1980 · Cited by 57 · see citing works
Self-citationCombined Infection of Mice with H. Influenzae and Influenza Virus by the Intranasal Route
Francis, T., & De Torregrosa, M. V. (1945) · Journal of Infectious Diseases · doi:10.1093/infdis/76.1.70 · Cited by 56 · see citing works
Giebink, G. S., Berzins, D. K., Schiffman, G., et al. (1979) · The Journal of Infectious Diseases · doi:10.1093/infdis/140.5.716 · Cited by 52 · see citing works
Self-citationA Longitudinal Study of Cellular Changes in Experimental Otitis Media
Goycoolea, M. V., Paparella, M. M., Carpenter, A., et al. (1979) · Otolaryngology · doi:10.1177/019459987908700524 · Cited by 51 · see citing works
Depression of Human Neutrophil Motility by Influenza Virus In Vitro
Ruutu, P., Vaheri, A., & Kosunen, T. (1977) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1977.tb00410.x · Cited by 48 · see citing works
DEATH FROM ASIATIC INFLUENZA IN THE NETHERLANDS
Hers, J. F. P., Goslings, W. R. O., Masurel, N., & Mulder, J. (1957) · The Lancet · doi:10.1016/s0140-6736(57)92066-4 · Cited by 46 · see citing works
Beall, G. D., Repine, J. E., Hoidal, J. R., & Rasp, F. L. (1977) · Infection and Immunity · doi:10.1128/iai.17.1.117-120.1977 · Cited by 44 · see citing works
Effect of viruses on luminol-dependent chemiluminescence of human neutrophils
Faden, H. S., Sutyla, P., & Ogra, P. L. (1979) · Infection and Immunity · doi:10.1128/iai.24.3.673-678.1979 · Cited by 37 · see citing works
Polymorphonuclear leukocyte dysfunction in children with recurrent otitis media
Giebink, G. S., Mills, E. L., Huff, J. S., et al. (1979) · The Journal of Pediatrics · doi:10.1016/s0022-3476(79)80342-x · Cited by 35 · see citing works
Self-citationLASMA AND CELL‐DERIVED INHIBITORS OF HUMAN NEUTROPHIL CHEMOTAXIS
Goetzl, E. J. (1975) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1975.tb36048.x · Cited by 35 · see citing works
Bactericidal and Metabolic Function of Polymorphonuclear Leukocytes
Quie, P. G., & Mills, E. L. (1979) · PEDIATRICS · doi:10.1542/peds.64.5.719 · Cited by 33 · see citing works
Self-citationAnimal Models for Studying Pneumococcal Otitis Media and Pneumococcal Vaccine Efficacy
Giebink, G. S., Berzins, I. K., & Quie, P. G. (1980) · Annals of Otology Rhinology & Laryngology · doi:10.1177/00034894800890s380 · Cited by 33 · see citing works
Self-citationEffect of virus infections on polymorph function in children.
Craft, A. W., Reid, M. M., & Low, W. T. (1976) · BMJ · doi:10.1136/bmj.1.6025.1570 · Cited by 30 · see citing works
Measles pneumonia. Bacterial suprainfection as a complicating factor
Olson, R. W. (1975) · JAMA · doi:10.1001/jama.232.4.363 · Cited by 29 · see citing works
The aetiology of pneumonia associated with measles in Bantu children.
Wesley, A. G., Jb, S., & Aj, W. (1971) · PubMed · Cited by 27 · see citing works
THE PULMONARY COMPLICATIONS OF INFLUENZA AS SEEN IN SHEFFIELD IN 1949
Tyrrell, D. A. J. (1952) · QJM · doi:10.1093/oxfordjournals.qjmed.a066653 · Cited by 27 · see citing works
Larson, H. E., Parry, R. P., Gilchrist, C., Luquetti, A. O., & Tyrrell, D. A. J. (1977) · PubMed Central · Cited by 25 · see citing works
Cytomegalovirus and Dual Infection in Infants
Bale, J. F., Reiley, T. T., Bray, P. F., et al. (1980) · Archives of Neurology · doi:10.1001/archneur.1980.00500530074012 · Cited by 22 · see citing works
Etiology of Pertussis Syndrome
Keller, M., Aftandelians, R., & Connor, J. D. (1980) · PEDIATRICS · doi:10.1542/peds.66.1.50 · Cited by 18 · see citing works
Taylor, R. N., Dietz, T. M., Maxwell, K. W., & Marcus, S. (1974) · Immunological Communications · doi:10.3109/08820137409061124 · Cited by 14 · see citing works
PHAGOCYTIC ACTIVITY OF NEUTROPHILIC LEUKOCYTES OF A2 INFLUENZA PATIENTS
Ruutu, T., & Kosunen, T. U. (1971) · Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology · doi:10.1111/j.1699-0463.1971.tb00034.x · Cited by 10 · see citing works
The effect of influenza virus on human polymorphonuclear leukocytes
Debets-Ossenkopp, Y. J., van Dijk, W. C., Mills, E. L., Verbrugh, H. A., & Verhoef, J. (1980) · Antonie van Leeuwenhoek · doi:10.1007/bf00422240 · Cited by 5 · see citing works
Self-citationVirus and rickettsial diseases in otorhinolaryngology.
BELLUSSI, G., FILIPPI, P., & SCALFI, L. (1959) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Insights into the Interaction between Influenza Virus and Pneumococcus
McCullers, J. A. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00058-05 · Cited by 846 · see citing works
Sun, K., & Metzger, D. W. (2008) · Nature Medicine · doi:10.1038/nm1765 · Cited by 587 · see citing works
Secondary bacterial infections associated with influenza pandemics
Morris, D. E., Cleary, D. W., & Clarke, S. C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01041 · Cited by 576 · see citing works
Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice
Shahangian, A., Chow, E. K., Tian, X., Kang, J. R., Ghaffari, A., Liu, S. Y., Belperio, J. A., Cheng, G., & Deng, J. C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35412 · Cited by 479 · see citing works
Respiratory viruses predisposing to bacterial infections: role of neuraminidase.
PELTOLA, V. T., & MCCULLERS, J. A. (2004) · Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000108197.81270.35 · Cited by 290 · see citing works
McNamee, L. A., & Harmsen, A. G. (2006) · Infection and Immunity · doi:10.1128/iai.00789-06 · Cited by 233 · see citing works
Pittet, L. A., Hall-Stoodley, L., Rutkowski, M. R., & Harmsen, A. G. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0417oc · Cited by 216 · see citing works
Abramson, J. S., Mills, E. L., Giebink, G. S., & Quie, P. G. (1982) · Infection and Immunity · doi:10.1128/iai.35.1.350-355.1982 · Cited by 96 · see citing works
Self-citationGrijalva, C. G., Griffin, M. R., Edwards, K. M., Williams, J. V., Gil, A. I., Verastegui, H., Hartinger, S. M., Vidal, J. E., Klugman, K. P., & Lanata, C. F. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu148 · Cited by 72 · see citing works
Disease Severity in Patients with Simultaneous Influenza and Bacterial Pneumonia
Seki, M., Kosai, K., Yanagihara, K., Higashiyama, Y., Kurihara, S., Izumikawa, K., Miyazaki, Y., Hirakata, Y., Tashiro, T., & Kohno, S. (2007) · Internal Medicine · doi:10.2169/internalmedicine.46.6364 · Cited by 57 · see citing works
Takase, H., Nitanai, H., Yamamura, E., & Otani, T. (1999) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1999.tb01226.x · Cited by 18 · see citing works
- Authors
- Abramson, J. S., Giebink, G. S., Mills, E. L., & Quie, P. G.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Abramson, J. S.
- ORCID
- Abramson, J. S.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1981-06-01
- Volume
- 143
- Issue
- 6
- Pages
- 836-845
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2169998037
- Cited by
- 88
- References
- 42
- Citations by year
- 2024: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 5 · 2013: 2 · 2012: 1
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- influenza A virus, polymorphonuclear leukocytes, neutrophil dysfunction, Streptococcus pneumoniae, pneumococcal otitis media, chemotaxis, chemiluminescence, bactericidal activity, phagocytosis, host defense, chinchilla, secondary infection susceptibility
- MeSH terms
- Animals, Blood Bactericidal Activity, Chemotaxis, Leukocyte, Chinchilla, Complement Fixation Tests, Luminescent Measurements, Nasopharynx, Neutrophils, Orthomyxoviridae Infections, Influenza A virus, Phagocytosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review