In vivo and in vitro degradation of glycine/DL‐lactic acid copolymers

Schakenraad, J. M.; Nieuwenhuis, P.; Molenaar, I.; Helder, J.; Dijkstra, P. J.; Feijen, J.

doi:10.1002/jbm.820231105

Cited by 101biodegradable polymer synthesis and propertiesSurgical Sutures and AdhesivesAdvanced Drug Delivery Systems

In vivo and in vitro degradation of glycine/DL‐lactic acid copolymers

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Schakenraad, J. M., Nieuwenhuis, P., Molenaar, I., Helder, J., Dijkstra, P. J., Feijen, J.·1989·Journal of Biomedical Materials Research

DOI 10.1002/jbm.820231105

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Abstract

A series of copolymers of glycine and DL‐lactic acid with various compositions was synthesized and their in vivo and in vitro degradation behavior was studied. For the in vivo examination, discs of the copolymer films were subcutaneously implanted in rats. The in vitro studies were carried out in phosphate buffer at pH = 7.4 and 37°C. The decrease in molecular weight, the loss of weight, and the tissue reactions of the different copolymers were determined after 2, 5, and 10 weeks. Poly(DL‐lactic acid) was used as reference material. The in vivo and in vitro degradation behavior of the polymers was comparable. The decrease of molecular weight of the copolymers and poly(DL‐lactic acid) in time was similar. The weight loss for copolymers with a higher mole fraction of glycine units started earlier. The copolymer with the highest content of glycine units disappeared completely within 10 weeks both in vivo and in vitro. The poly(DL‐lactic acid) implant lost only 25% weight over the same period. Tissue reactions against all materials started with an acute inflammatory reaction caused by the trauma of implantation, followed by wound‐healing processes, ending in a very mild foreign body reaction for the poly(DL‐lactic acid) and a more excessive macrophage mediated foreign body reaction for the glycine/DL‐lactic acid copolymers. The tissue reaction was more severe for polymers having a higher rate of degradation.

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“although certain studies (Schakenraad et al., 1989;VanSliedregt et al., 1990VanSliedregt et al., , 1992;;Verheyen et al., 1993) suggest otherwise.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Schakenraad et al., 1989

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Authors: Schakenraad, J. M., Nieuwenhuis, P., Molenaar, I., Helder, J., Dijkstra, P. J., & Feijen, J.
Affiliations: University of Groningen (NL)
University of Twente (NL)
ORCID: Nieuwenhuis, P.
Dijkstra, P. J.
Venue: Journal of Biomedical Materials Research
Publisher: Wiley
Published: 1989-11
Volume: 23
Issue: 11
Pages: 1271-1288
ISSN: 0021-9304 (ISSN-L)
1097-4636
DOI: 10.1002/jbm.820231105
OpenAlex: W2143016545
Cited by: 101
References: 33
Citations by year: 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 4
FWCI: 3.08
Type: journal article
Language: en
Open access: green
research.utwente.nl
Licence: other-oa
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5430 d)
Locations: Journal of Biomedical Materials Research (publishedVersion)
PubMed (publishedVersion)
University of Twente Research Information (submittedVersion, other-oa)
Topics: Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: poly(D,L-lactide), biodegradation, in vivo degradation, in vitro degradation, subcutaneous implantation, molecular weight reduction, weight loss, foreign body reaction, macrophage response, tissue reaction, biodegradable polymers, copolymer composition
MeSH terms: Animals, Biodegradation, Environmental, Chemistry, Physical, Female, Polymers, Time Factors, Rats, Chemical Phenomena

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In vivo and in vitro degradation of glycine/DL‐lactic acid copolymers

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