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Autocrine Secretion and Malignant Transformation of Cells
Abstract
The growth of normal cells is largely controlled by the interplay between several polypeptide hormones and hormone-like growth factors that are present in tissue fluids.1 Many new polypeptide growth factors have recently been identified in blood, serum, tissue fluids, and cellular extracts.2 ,23 Malignant cells, however, are not subject to all the same growth controls as are normal cells. In general, malignant cells require less of these exogenous growth factors than do their normal counterparts for optimal growth and multiplication, and it has been suggested that "transformed or malignant cells escape from normal growth controls by requiring less of [such] hormones . . .
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Cited by
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Downward, J., Yarden, Y., Mayes, E., Scrace, G., Totty, N., Stockwell, P., Ullrich, A., Schlessinger, J., & Waterfield, M. D. (1984) · Nature · doi:10.1038/307521a0 · Cited by 2,516
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., et al. (1988) · Nature · doi:10.1038/332083a0 · Cited by 1,633
Bone Cell Differentiation and Growth Factors
Urist, M. R., DeLange, R. J., & Finerman, G. A. M. (1983) · Science · doi:10.1126/science.6403986 · Cited by 873
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Salazar, V. S., Gamer, L. W., & Rosen, V. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.12 · Cited by 822
Jhappan, C., Stahle, C., Harkins, R. N., Fausto, N., Smith, G. H., & Merlino, G. T. (1990) · Cell · doi:10.1016/0092-8674(90)90076-q · Cited by 710
Metadata
- Authors
- Sporn, M. B., & Todaro, G. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-10-09
- Volume
- 303
- Issue
- 15
- Pages
- 878-880
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2068961038
- Cited by
- 1,346
- References
- 0
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sporn, M. B., & Todaro, G. J. (1980). Autocrine Secretion and Malignant Transformation of Cells. New England Journal of Medicine. https://doi.org/10.1056/nejm198010093031511
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
