The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Reduced Activity of the Red-Cell Sodium-Potassium Pump in Human Obesity
Abstract
Looking for evidence of reduced energy use in the cells of obese persons, we measured the numbers of sodium-potassium-pump units in erythrocytes from a group of 21 obese human subjects and found them to be reduced by 22 per cent as compared with those of nonobese controls (P <0.001). The cation-transport activity of the pump, as measured by 86rubidium uptake by the cells, we also reduced in parallel with decrease in pump units. An increased concentration of sodium in the red cells of obese subjectes was also found (9.6 +/- 0.7 vs. 7.1 +/- 0.6 mmol per liter of cells; P<0.01). This finding demonstrates independently the physiologic importance of reduced numbers of sodium-pump units and reduced pump activity as measured by ouabain binding and rubidium transport, respectively. The magnitude of the reduction in the number of pump units was found to be negatively correlated with the percentage of ideal body weight (r = 0.56, P<0.001); this observation suggests a possible role of abnormalities of the sodium pump in the pathophysiology of obesity.
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Cites
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Increased Sodium-Lithium Countertransport in Red Cells of Patients with Essential Hypertension
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Uptake and metabolism of γ-aminobutyric acid by neurones and glial cells
Iversen, L. L., & Kelly, J. S. (1975) · Biochemical Pharmacology · doi:10.1016/0006-2952(75)90422-0 · Cited by 564
Endocrine and Metabolic Effects of Experimental Obesity in Man
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The gradient hypothesis and other models of carrier-mediated active transport
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Reduced thermogenesis in obesity
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Thermogenic defect in pre-obese ob/ob mice
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Active Transport of Sodium and Potassium Ions: Mechanism, Function, and Regulation
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Cited by
Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
Modan, M., Halkin, H., Almog, S., Lusky, A., Eshkol, A., Shefi, M., Shitrit, A., & Fuchs, Z. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111776 · Cited by 1,465
Diabetes mellitus and hypertension.
Epstein, M., & Sowers, J. R. (1992) · Hypertension · doi:10.1161/01.hyp.19.5.403 · Cited by 600
Severely Impaired Adipsin Expression in Genetic and Acquired Obesity
Flier, J. S., Cook, K. S., Usher, P., & Spiegelman, B. M. (1987) · Science · doi:10.1126/science.3299706 · Cited by 329
Self-citationWright, R. A., Krinsky, S., Fleeman, C., Trujillo, J., & Teague, E. (1983) · Gastroenterology · doi:10.1016/0016-5085(83)90141-5 · Cited by 278
CD36 and Na/K-ATPase-α1 Form a Proinflammatory Signaling Loop in Kidney
Kennedy, D. J., Chen, Y., Huang, W., Viterna, J., Liu, J., Westfall, K., Tian, J., Bartlett, D. J., Tang, W. H. W., Xie, Z., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.112.198770 · Cited by 101
Metadata
- Authors
- Luise, M. D., Blackburn, G. L., & Flier, J. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-10-30
- Volume
- 303
- Issue
- 18
- Pages
- 1017-1022
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2341056698
- Cited by
- 293
- References
- 15
- FWCI
- 19.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reduced Activity of the Red-Cell Sodium-Potassium Pump in Human Obesity. https://app.cochat.ai/papers/10.1056/nejm198010303031801
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- Luise, M. D., Blackburn, G. L., & Flier, J. S. (1980). Reduced Activity of the Red-Cell Sodium-Potassium Pump in Human Obesity. New England Journal of Medicine. https://doi.org/10.1056/nejm198010303031801
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
