Thermogenic defect in pre-obese ob/ob mice
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Studies of pair-fed genetically obese mice have clearly shown a defect in BAT-mediated thermogenesis.
“Studies of pair-fed genetically obese mice have clearly shown a defect in BAT-mediated thermogenesis 50,51.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [50]
Cites
Genetically transmitted obesity in rodents
Bray, G. A., & York, D. A. (1971) · Physiological Reviews · doi:10.1152/physrev.1971.51.3.598 · Cited by 398 · see citing works
Effect of Food Restriction on Body Composition of Hereditary Obese Mice
Alonso, L. G., & Maren, T. H. (1955) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1955.183.2.284 · Cited by 187 · see citing works
Imperfect Homeothermia in the Hereditary Obese-Hyperglycemic Syndrome of Mice
Davis, T. R. A., & Mayer, J. (1954) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1954.177.2.222 · Cited by 175 · see citing works
AN INTEGRATED VIEW OF THE METABOLIC AND GENETIC BASIS FOR OBESITY
James, W. P. T. (1976) · The Lancet · doi:10.1016/s0140-6736(76)90602-4 · Cited by 92 · see citing works
Self-citationBody composition of mice with gold thioglucose and hereditary obesity after weight reduction.
Hollifield, G., & Parson, W. (1958) · PubMed · Cited by 86 · see citing works
Core temperature, O2 consumption, and early detection of ob-ob genotype in mice
Kaplan, M. L., & Leveille, G. A. (1974) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1974.227.4.912 · Cited by 69 · see citing works
Welton, R. F., Martin, R. J., & Baumgardt, B. R. (1973) · Journal of Nutrition · doi:10.1093/jn/103.8.1212 · Cited by 24 · see citing works
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Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998 · see citing works
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105 · see citing works
Stern, J. H., Rutkowski, J. M., & Scherer, P. E. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.011 · Cited by 1,031 · see citing works
Cellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works
Rosenbaum, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25977 · Cited by 575 · see citing works
van de Wall, E., Leshan, R., Xu, A. W., Balthasar, N., Coppari, R., Liu, S. M., Jo, Y. H., MacKenzie, R. G., Allison, D. B., Dun, N. J., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1132 · Cited by 338 · see citing works
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Brown Adipose Tissue: Mechanisms and Potential Therapeutic Targets
Tam, C. S., Lecoultre, V., & Ravussin, E. (2012) · Circulation · doi:10.1161/circulationaha.111.042929 · Cited by 116 · see citing works
Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice
Berbari, N. F., Pasek, R. C., Malarkey, E. B., Yazdi, S. M. Z., McNair, A. D., Lewis, W. R., Nagy, T. R., Kesterson, R. A., & Yoder, B. K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210192110 · Cited by 98 · see citing works
The Role of Leptin in the Regulation of Energy Balance and Adiposity
Van Dijk, G. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00707.x · Cited by 75 · see citing works
- Authors
- TRAYHURN, P., THURLBY, P. L., & JAMES, W. P. T.
- ORCID
- TRAYHURN, P.
- Venue
- Nature
- Published
- 1977-03-01
- Volume
- 266
- Issue
- 5597
- Pages
- 60-62
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1986333814
- Cited by
- 221
- References
- 7
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 12 · 2017: 4 · 2016: 7 · 2015: 9 · 2014: 6 · 2013: 5 · 2012: 6
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Keywords
- ob/ob mice, leptin deficiency, thermogenesis, cold stress response, thermoregulation, hypothermia, pre-obesity, genetic obesity, thermic effect of food, basal metabolic rate
- MeSH terms
- Age Factors, Animals, Body Temperature Regulation, Cold Temperature, Mice, Obese, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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