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Characterization of Immunoregulatory T Cells in EBV-Induced Infectious Mononucleosis by Monoclonal Antibodies
Abstract
IN infectious mononucleosis induced by Epstein–Barr virus (EBV), an initial viral infection of B lymphocytes1 is usually followed by an extensive proliferation of T cells.2 , 3 In functional studies these T cells are cytotoxic against EBV-infected lymphoid cells4 , 5 and inhibit their outgrowth.6 In addition, they suppress autologous T-cell proliferation to antigens as well as B-cell immunoglobulin production stimulated by pokeweed mitogen.7 , 8 They are thought to be of major importance in the self-limiting aspect of the disease.Maturation and differentiation of T-lymphoid cells into lymphocyte subsets with particular immunologic functions is expressed by distinctive patterns of cell-surface antigens.9 Recently, monoclonal antibodies directed . . .
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Cited by
Gottlieb, M. S., Schroff, R., Schanker, H. M., Weisman, J. D., Fan, P. T., Wolf, R. A., & Saxon, A. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112103052401 · Cited by 2,728
Herpesvirus Infections in the Acquired Immune Deficiency Syndrome
Quinnan, G. V. (1984) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1984.03350010038020 · Cited by 398
Opportunistic Infections and Immune Deficiency in Homosexual Men
MILDVAN, D., MATHUR, U., ENLOW, R. W., ROMAIN, P. L., WINCHESTER, R. J., COLP, C., SINGMAN, H., ADELSBERG, B. R., & SPIGLAND, I. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-96-6-700 · Cited by 377
Immunologic abnormalities in homosexual men
Stahl, R. E., Friedman-Kien, A., Dubin, R., Marmor, M., & Zolla-Pazner, S. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90174-7 · Cited by 318
Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection
Roos, M. T. L., Lange, J. M. A., de Goede, R. E. Y., Coutinho, R. A., Schellekens, P. T. A., Miedema, F., & Tersmette, M. (1992) · Journal of Infectious Diseases · doi:10.1093/infdis/165.3.427 · Cited by 266
Metadata
- Authors
- Waele, M. D., Thielemans, C., & Van Camp, B. K. G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1981-02-19
- Volume
- 304
- Issue
- 8
- Pages
- 460-462
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2062868034
- Cited by
- 259
- References
- 0
- FWCI
- 22.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Characterization of Immunoregulatory T Cells in EBV-Induced Infectious Mononucleosis by Monoclonal Antibodies. https://app.cochat.ai/papers/10.1056/nejm198102193040804
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- Waele, M. D., Thielemans, C., & Van Camp, B. K. G. (1981). Characterization of Immunoregulatory T Cells in EBV-Induced Infectious Mononucleosis by Monoclonal Antibodies. New England Journal of Medicine. https://doi.org/10.1056/nejm198102193040804
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
