The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection
Abstract
Nineteen individuals were studied for virologic and immunologic events during primary human immunodeficiency virus type 1 (HIV-1) infection. In 16 individuals only non-syncytium-inducing (NSI) isolates were detected; syncytium-inducing (SI) isolates were obtained from 3. Studies of transmitter-recipient pairs indicated that both NSI variants and SI variants were transmitted and that SI variants may be suppressed in the recipient. CD4+ T cells remained in the normal range in 15 of 16 individuals with NSI isolates but rapidly declined in all 3 individuals with SI variants, 1 of whom was treated with zidovudine. The most marked increase in CD8+ T cells and activated CD8+ T cells was observed in individuals with the most pronounced clinical signs of acute HIV-1 infection. Activated CD8+ T cells were only transiently elevated in individuals with SI variants, suggesting that an impaired cellular anti-HIV-1 immune response plays a role in the rapid progression to AIDS.
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Self-citationDaar, E. S., Moudgil, T., Meyer, R. D., & Ho, D. D. (1991) · New England Journal of Medicine · doi:10.1056/nejm199104043241405 · Cited by 838
ACUTE AIDS RETROVIRUS INFECTION
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High Titers of Cytopathic Virus in Plasma of Patients with Symptomatic Primary HIV-1 Infection
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Conserved Sequence and Structural Elements in the HIV-1 Principal Neutralizing Determinant
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Cited by
Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Winkler, C., Modi, W., Smith, M. W., Nelson, G. W., Wu, X., Carrington, M., Dean, M., Honjo, T., Tashiro, K., Yabe, D., et al. (1998) · Science · doi:10.1126/science.279.5349.389 · Cited by 710
Weiss, R. A. (1993) · Science · doi:10.1126/science.8493571 · Cited by 680
Metadata
- Authors
- Roos, M. T. L., Lange, J. M. A., de Goede, R. E. Y., Coutinho, R. A., Schellekens, P. T. A., Miedema, F., & Tersmette, M.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-03-01
- Volume
- 165
- Issue
- 3
- Pages
- 427-432
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2164371532
- Cited by
- 266
- References
- 27
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection. https://app.cochat.ai/papers/10.1093/infdis/165.3.427
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- Roos, M. T. L., Lange, J. M. A., de Goede, R. E. Y., Coutinho, R. A., Schellekens, P. T. A., Miedema, F., & Tersmette, M. (1992). Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/165.3.427
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
