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Cited by 287

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Treatment of Primary Breast Cancer with Chemotherapy and Tamoxifen

Fisher, Bernard, Redmond, Carol, Brown, Ann, Wolmark, Norman, Wittliff, James, Fisher, Edwin R., Plotkin, David, Bowman, David, Sachs, Sidney, Wolter, Janet, Frelick, Robert, Desser, Richard, LiCalzi, Nicholas, Geggie, Peter, Campbell, Thomas, Elias, E. George, Prager, David, Koontz, Paul, Volk, Herbert, Dimitrov, Nikolay, Gardner, Bernard, Lerner, Harvey, Shibata, Henry·1981·New England Journal of Medicine
DOI 10.1056/nejm198107023050101
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Abstract

We studied the possibility that the addition of tamoxifen to L-phenylalanine mustard combined with 5-fluorouracil enhances the benefit from the latter two drugs that has been observed in women with primary breast cancer and positive axillary nodes. Recurrence of disease was reduced at two years in patients given the three-drug regimen whose tumor estrogen-receptor levels were greater than or equal to 10 fmol. Among patients greater than or equal to 50 years old treatment failure was significantly reduced (P less than 0.001): by 51 per cent in those with one to three positive nodes and by 64 per cent in those with four or more. Higher receptor levels were associated with a greater probability of disease-free survival. Patients less than or equal to 49 years old were less responsive: those with one to three positive nodes received no benefit from tamoxifen at any receptor level, whereas those with four or more appeared to have reduced treatment failure associated with higher receptor levels. This adjuvant chemotherapy is not indicated in patients less than or equal to 49 years old whose tumor receptor levels are below 10 fmol; there is a suggestion of benefit in patients greater than or equal to 50 years old whose levels are low.

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Metadata

Authors
Fisher, B., Redmond, C., Brown, A., Wolmark, N., Wittliff, J., Fisher, E. R., Plotkin, D., Bowman, D., Sachs, S., Wolter, J., Frelick, R., Desser, R., LiCalzi, N., Geggie, P., Campbell, T., Elias, E. G., Prager, D., Koontz, P., Volk, H., Dimitrov, N., Gardner, B., Lerner, H., & Shibata, H.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1981-07-02
Volume
305
Issue
1
Pages
1-6
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198107023050101
OpenAlex
W2329949221
Cited by
287
References
6
FWCI
16.30
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Treatment of Primary Breast Cancer with Chemotherapy and Tamoxifen. https://app.cochat.ai/papers/10.1056/nejm198107023050101
The paper
Fisher, B., Redmond, C., Brown, A., Wolmark, N., Wittliff, J., Fisher, E. R., Plotkin, D., Bowman, D., Sachs, S., Wolter, J., Frelick, R., Desser, R., LiCalzi, N., Geggie, P., Campbell, T., Elias, E. G., Prager, D., Koontz, P., Volk, H., . . . Shibata, H. (1981). Treatment of Primary Breast Cancer with Chemotherapy and Tamoxifen. New England Journal of Medicine. https://doi.org/10.1056/nejm198107023050101

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.