The DOI matches its Crossref record.
Scintigraphic Localization of Pheochromocytoma
Abstract
We used a new radiopharmaceutical agent, [131I]meta-iodobenzylguanidine ([131I]MIBG), to produce scintigraphic images of pheochromocytomas in eight patients. One day or more after injection, the only normal organ that displayed distinct concentrations of radioactivity was the urinary bladder. The [131I]MIBG was probably concentrated in adrenergic vesicles; in tissues where vesicles are numerous, such as pheochromocytomas, the radionuclide was retained for days. The spectrum of pheochromocytomas shown the scintigrams was broad: intra-adrenal and extraadrenal in location, benign and malignant in character, 0.2 to 65 g in weight, and with different hormone patterns in secretion. Tumors in four patients were not detected by computed tomography. In one patient, reoperation was undertaken only because the scintigram located the extra-adrenal tumors and thereby directed the surgeon's exploration. The method offers hope of safe and reliable localization of pheochromocytomas in their many guises.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Recent advances in genetics, diagnosis, localization, and treatment of pheochromocytoma
Pacak, K., Linehan, W. M., Eisenhofer, G., Walther, M. M., & Goldstein, D. S. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-4-200102200-00016 · Cited by 618
Pheochromocytoma: State-of-the-Art and Future Prospects
Bravo, E. L., & Tagle, R. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0013 · Cited by 493
Pheochromocytoma: Diagnosis, Localization and Management
Bravo, E. L., & Gifford, R. W. (1984) · New England Journal of Medicine · doi:10.1056/nejm198411153112007 · Cited by 471
Eisenhofer, G. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00144-9 · Cited by 342
Current Approaches and Recommended Algorithm for the Diagnostic Localization of Pheochromocytoma
Ilias, I., & Pacak, K. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031091 · Cited by 332
Metadata
- Authors
- Sisson, J. C., Frager, M. S., Valk, T. W., Gross, M. D., Swanson, D. P., Wieland, D. M., Tobes, M. C., Beierwaltes, W. H., & Thompson, N. W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1981-07-02
- Volume
- 305
- Issue
- 1
- Pages
- 12-17
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2005455936
- Cited by
- 544
- References
- 0
- FWCI
- 45.07
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Scintigraphic Localization of Pheochromocytoma. https://app.cochat.ai/papers/10.1056/nejm198107023050103
- The paper
- Sisson, J. C., Frager, M. S., Valk, T. W., Gross, M. D., Swanson, D. P., Wieland, D. M., Tobes, M. C., Beierwaltes, W. H., & Thompson, N. W. (1981). Scintigraphic Localization of Pheochromocytoma. New England Journal of Medicine. https://doi.org/10.1056/nejm198107023050103
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
