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Use of Monoclonal Antibodies to T-Cell Subsets for Immunologic Monitoring and Treatment in Recipients of Renal Allografts
Abstract
Using monoclonal antibodies and flow cytometry, wer serially monitored lymphocyte subpopulations in renal-allograft recipients treated with either conventional immunosuppression or a monoclonal antibody. In 29 patients given conventional suppression, highly significant correlations between changes in T-cell subsets and rejection were noted. Normal or elevated ratios of OKT4 (helper/inducer) to OKT8 (suppressor/cytotoxic) cells were associated with rejection unless the donor was HLA identical or the total number of T cells was extremely low. In patients with low ratios, rejection seldom occurred. Two patients treated with OKT3 monoclonal antibody for acute rejection had rapid disappearance of OKT3-reactive cells from the peripheral blood and prompt reversal of rejection. The use of monoclonal antibodies allows the precise determination of changes in T-cell subsets and promises the development of therapeutic protocols that can be designed to manipulate selected lymphocyte populations.
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Citations
Cited by
Ortho Multicenter Transplant Study Group* (1985) · New England Journal of Medicine · doi:10.1056/nejm198508083130601 · Cited by 708
Miethke, T., Wahl, C., Heeg, K., Echtenacher, B., Krammer, P. H., & Wagner, H. (1992) · The Journal of experimental medicine · doi:10.1084/jem.175.1.91 · Cited by 574
Mizuhara, H., O'Neill, E., Seki, N., Ogawa, T., Kusunoki, C., Otsuka, K., Satoh, S., Niwa, M., Senoh, H., & Fujiwara, H. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.5.1529 · Cited by 517
Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4.
Wofsy, D., & Seaman, W. E. (1985) · The Journal of experimental medicine · doi:10.1084/jem.161.2.378 · Cited by 458
Antman, E. M., Wenger, T. L., Butler, V. P., Haber, E., & Smith, T. W. (1990) · Circulation · doi:10.1161/01.cir.81.6.1744 · Cited by 393
Metadata
- Authors
- Cosimi, A. B., Colvin, R. B., Burton, R. C., Rubin, R. H., Goldstein, G., Kung, P. C., Hansen, W. P., Delmonico, F. L., & Russell, P. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1981-08-06
- Volume
- 305
- Issue
- 6
- Pages
- 308-314
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2332022311
- Cited by
- 505
- References
- 0
- FWCI
- 56.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Use of Monoclonal Antibodies to T-Cell Subsets for Immunologic Monitoring and Treatment in Recipients of Renal Allografts. https://app.cochat.ai/papers/10.1056/nejm198108063050603
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- Cosimi, A. B., Colvin, R. B., Burton, R. C., Rubin, R. H., Goldstein, G., Kung, P. C., Hansen, W. P., Delmonico, F. L., & Russell, P. S. (1981). Use of Monoclonal Antibodies to T-Cell Subsets for Immunologic Monitoring and Treatment in Recipients of Renal Allografts. New England Journal of Medicine. https://doi.org/10.1056/nejm198108063050603
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
