The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
A Randomized Clinical Trial of OKT3 Monoclonal Antibody for Acute Rejection of Cadaveric Renal Transplants
Abstract
Since the murine monoclonal antibody OKT3 reacts with human T cells and blocks their function, we explored its effectiveness in treating T-cell-mediated rejection of renal allografts. In a prospective randomized multicenter trial, 123 patients undergoing acute rejection of cadaveric renal transplants were treated either with OKT3 daily for a mean of 14 days, with concomitant lowering of the dosage of other immunosuppressive drugs (63 patients), or with conventional high-dose steroids (60 patients). OKT3 reversed 94 per cent of the rejections--a figure that was significantly better (P = 0.009) than the 75 per cent reversal rate obtained with conventional steroid treatment. This superior reversal rate with OKT3 was reflected in an improved one-year graft survival of 62 per cent for the OKT3-treated group, as compared with 45 per cent for the steroid-treated group (P = 0.029), in patients who were all selected by virtue of having had acute rejection. We conclude that treatment with OKT3 (with concomitant lowering of the dosage of other immunosuppressive drugs) is an effective approach for acute renal-allograft rejection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Chi-Square Tests with One Degree of Freedom; Extensions of the Mantel-Haenszel Procedure
Mantel, N. (1963) · Journal of the American Statistical Association · doi:10.1080/01621459.1963.10500879 · Cited by 2,897
Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens
Kung, P. C., Goldstein, G., Reinherz, E. L., & Schlossman, S. F. (1979) · Science · doi:10.1126/science.314668 · Cited by 1,453
A generalized Kruskal-Wallis test for comparing K samples subject to unequal patterns of censorship
BRESLOW, N. (1970) · Biometrika · doi:10.1093/biomet/57.3.579 · Cited by 1,411
SOME RAPID APPROXIMATE STATISTICAL PROCEDURES
Wilcoxon, F. (1950) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1950.tb53974.x · Cited by 1,200
OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.
Van Wauwe, J. P., De Mey, J. R., & Goossens, J. G. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.124.6.2708 · Cited by 582
Cosimi, A. B., Colvin, R. B., Burton, R. C., Rubin, R. H., Goldstein, G., Kung, P. C., Hansen, W. P., Delmonico, F. L., & Russell, P. S. (1981) · New England Journal of Medicine · doi:10.1056/nejm198108063050603 · Cited by 505
TREATMENT OF ACUTE RENAL ALLOGRAFT REJECTION WITH OKT3 MONOCLONAL ANTIBODY
Cosimi, A. B., BURTON, R. C., COLVIN, R. B., GOLDSTEIN, G., DELMONICO, F. L., LAQUAGLIA, M. P., TOLKOFF-RUBIN, N., RUBIN, R. H., HERRIN, J. T., & RUSSELL, P. S. (1981) · Transplantation · doi:10.1097/00007890-198112000-00018 · Cited by 389
Biddison, W. E., Rao, P. E., Talle, M. A., Goldstein, G., & Shaw, S. (1982) · The Journal of experimental medicine · doi:10.1084/jem.156.4.1065 · Cited by 304
Does OKT3 monoclonal antibody react with an antigen-recognition structure on human T cells?
Chang, T. W., Kung, P. C., Gingras, S. P., & Goldstein, G. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.3.1805 · Cited by 299
Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex
van den Elsen, P., Shepley, B.-A., Borst, J., Coligan, J. E., Markham, A. F., Orkin, S., & Terhorst, C. (1984) · Nature · doi:10.1038/312413a0 · Cited by 226
Cited by
Importance of Cellular Microenvironment and Circulatory Dynamics in B Cell Immunotherapy
Gong, Q., Ou, Q., Ye, S., Lee, W. P., Cornelius, J., Diehl, L., Lin, W. Y., Hu, Z., Lu, Y., Chen, Y., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.817 · Cited by 543
Human antibodies from transgenic animals.
Lonberg, N. (2005) · Nature Biotechnology · doi:10.1038/nbt1135 · Cited by 434
Antigen-specific human antibodies from mice comprising four distinct genetic modifications
Lonberg, N., Taylor, L. D., Harding, F. A., Trounstine, M., Higgins, K. M., Schramm, S. R., Kuo, C.-C., Mashayekh, R., Wymore, K., McCabe, J. G., et al. (1994) · Nature · doi:10.1038/368856a0 · Cited by 398
Therapeutic monoclonal antibodies
Breedveld, F. (2000) · The Lancet · doi:10.1016/s0140-6736(00)01034-5 · Cited by 359
CD3-specific antibody-induced active tolerance: from bench to bedside
Chatenoud, L. (2003) · Nature Reviews Immunology · doi:10.1038/nri1000 · Cited by 309
Metadata
- Authors
- Ortho Multicenter Transplant Study Group*
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-08-08
- Volume
- 313
- Issue
- 6
- Pages
- 337-342
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4233298376
- Cited by
- 708
- References
- 12
- FWCI
- 31.62
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Randomized Clinical Trial of OKT3 Monoclonal Antibody for Acute Rejection of Cadaveric Renal Transplants. https://app.cochat.ai/papers/10.1056/nejm198508083130601
- The paper
- Ortho Multicenter Transplant Study Group*. (1985). A Randomized Clinical Trial of OKT3 Monoclonal Antibody for Acute Rejection of Cadaveric Renal Transplants. New England Journal of Medicine. https://doi.org/10.1056/nejm198508083130601
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
