1,25‐dihydroxyvitamin D 3 promotes IL‐10 production in human B cells
Abstract
1,25‐dihydroxyvitamin D 3 (calcitriol) regulates immune responses, e.g. , inhibits expression of IgE by B cells and enhances expression of IL‐10 by dendritic cells and T cells. We report here that activation of human B cells by B cell receptor, CD40 and IL‐4 signals induces expression of the gene for 25‐hydroxyvitamin‐D3–1α‐hydroxylase (CYP1α). Accordingly, these B cells generate and secrete significant amounts of calcitriol. In activated B cells calcitriol induces expression of the genes Cyp24 , encoding a vitamin D hydroxylase, and Trpv6 , encoding a calcium selective channel protein. Calcitriol enhances IL‐10 expression of activated B cells more than threefold, both by recruiting the vitamin D receptor to the promoter of Il‐10, and to lesser extent by modulation of calcium‐dependent signaling. The molecular link in activated B cells between vitamin D signaling, expression of IgE and IL‐10, and their ability to produce calcitriol from its precursor, suggest that pro‐vitamin D (25‐hydroxyvitamin D 3 ) can be used as a modulator of allergic immune responses. Supporting Information for this article is available at http://www.wiley‐vch.de/contents/jc_2040/2008/38216_s.pdf
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Vitamin D has an effect on the immune system and can directly affect immune cells.
“It is well known that vitamin D has an effect on immune system and can directly affect immune cells.”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [163]
Vitamin D metabolites enhance the expression of anti-inflammatory cytokines such as IL-10 from activated B cells.
“For example, vitamin D metabolites have been shown to decrease the secretion of IL-6 and TNF-α [162], enhance the expression of anti-inflammatory cytokines such as interleukin 10 (IL–10) from activated B cells [163], and to direct dendritic cells (DCs) toward a more tolerogenic state [164].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [163]
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- Authors
- Heine, G., Niesner, U., Chang, H., Steinmeyer, A., Zügel, U., Zuberbier, T., Radbruch, A., & Worm, M.
- Affiliations
- German Rheumatism Research Centre (DE)
- Bayer (Germany) (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Worm, Margitta
- ORCID
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2008-07-24
- Volume
- 38
- Issue
- 8
- Pages
- 2210-2218
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W1963871427
- Cited by
- 311
- References
- 51
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 26 · 2021: 23 · 2020: 19 · 2019: 19 · 2018: 22 · 2017: 20 · 2016: 15 · 2015: 20 · 2014: 23 · 2013: 9 · 2012: 15
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- 1,25-dihydroxyvitamin D3, IL-10, B cells, vitamin D receptor, CYP24, TRPV6, B cell receptor signaling, CD40 signaling, IL-4 signaling, IgE, allergic immune response, vitamin D metabolism, calcium signaling
- MeSH terms
- B-Lymphocytes, Calcitriol, Calcium, Cells, Cultured, Humans, Steroid Hydroxylases, Interleukin-4, Interleukin-10, Receptors, Calcitriol, CD40 Antigens, Vitamin D3 24-Hydroxylase
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