The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Immunomodulatory role of 1,25‐dihydroxyvitamin D3
Abstract
The active vitamin D metabolite 1,25‐dihydroxyvitamin D 3 [1,25‐D 3] is thought to promote many of its actions through interaction with a specific intracellular receptor. The discovery of such receptors in monocytes and activated lymphocytes has led investigators to evaluate the role of the hormone on the immune system. The sterol inhibits lymphocyte proliferation and immunoglobulin production in a dose‐dependent fashion. At a molecular level, 1,25‐D 3 inhibits the accumulation of mRNA for IL‐2, IFN‐γ, and GM‐CSF. At a cellular level, the hormone interferes with T helper cell (T h) function, reducing T h‐induction of immunoglobulin production by B cells and inhibiting the passive transfer of cellular immunity by T h‐clones in vivo. The sterol promotes suppressor cell activity and inhibits the generation of cytotoxic and NK cells. Class II antigen expression on lymphocytes and monocytes is also affected by the hormone. When given in vivo, 1,25‐D 3 has been particularly effective in the prevention of autoimmune diseases such as experimental autoimmune encephalomyelitis and murine lupus but its efficacy has been limited by its hypercalcemic effect. Synthetic vitamin D 3 analogues showing excellent 1,25‐D 3‐receptor binding but less pronounced hypercalcemic effects in vivo have recently enhanced the immunosuppressive properties of the hormone in autoimmunity and transplantation.
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Cites
Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,506
1,25-Dihydroxyvitamin D 3 Receptors in Human Leukocytes
Provvedini, D. M., Tsoukas, C. D., Deftos, L. J., & Manolagas, S. C. (1983) · Science · doi:10.1126/science.6310748 · Cited by 1,031
The Role of the Vitamin D Endocrine System in Health and Disease
Reichel, H., Koeffler, H. P., & Norman, A. W. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904133201506 · Cited by 1,029
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.
Abe, E., Miyaura, C., Sakagami, H., Takeda, M., Konno, K., Yamazaki, T., Yoshiki, S., & Suda, T. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.4990 · Cited by 1,020
BHALLA, A. K., AMENTO, E. P., CLEMENS, T. L., HOLICK, M. F., & KRANE, S. M. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-6-1308 · Cited by 605
1,25-Dihydroxyvitamin D 3 : a Novel Immunoregulatory Hormone
Tsoukas, C. D., Provvedini, D. M., & Manolagas, S. C. (1984) · Science · doi:10.1126/science.6427926 · Cited by 526
Lemire, J. M., Adams, J. S., Sakai, R., & Jordan, S. C. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111465 · Cited by 508
Self-citationLemire, J. M., & Archer, D. C. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115072 · Cited by 472
Self-citationInhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol).
Rigby, W. F., Stacy, T., & Fanger, M. W. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111557 · Cited by 469
Barbour, G. L., Coburn, J. W., Slatopolsky, E., Norman, A. W., & Horst, R. L. (1981) · New England Journal of Medicine · doi:10.1056/nejm198108203050807 · Cited by 425
Cited by
Gender differences in autoimmune disease
Ngo, S. T., Steyn, F. J., & McCombe, P. A. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.004 · Cited by 1,074
Cantorna, M. T., Munsick, C., Bemiss, C., & Mahon, B. D. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.11.2648 · Cited by 494
The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells
Mahon, B. D., Wittke, A., Weaver, V., & Cantorna, M. T. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10580 · Cited by 466
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women
Richards, J. B., Valdes, A. M., Gardner, J. P., Paximadas, D., Kimura, M., Nessa, A., Lu, X., Surdulescu, G. L., Swaminathan, R., Spector, T. D., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1420 · Cited by 237
Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice
Froicu, M., Zhu, Y., & Cantorna, M. T. (2006) · Immunology · doi:10.1111/j.1365-2567.2005.02290.x · Cited by 128
Metadata
- Authors
- Lemire, J. M.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 1992-05
- Volume
- 49
- Issue
- 1
- Pages
- 26-31
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2135878618
- Cited by
- 299
- References
- 31
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- closed
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