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The Effect of Activated Prothrombin-Complex Concentrate (FEIBA) on Joint and Muscle Bleeding in Patients with Hemophilia A and Antibodies to Factor VIII: A Double-Blind Clinical Trial
Abstract
We designed a double-blind trial to study the effect of an "activated" prothrombin-complex concentrate (FEIBA) on joint and muscle bleeding in hemophiliacs with antibodies to factor VIII. Fifteen patients received either FEIBA or the control preparation (a nonactivated prothrombin-complex concentrate) for a total of 150 bleeding episodes (four mucocutaneous bleeding, 117 joint bleeding, and 29 muscle bleeding). In 64 per cent of the episodes, FEIBA was judged by the physician to be effective; the control preparation was perceived as effective in 52 per cent of the episodes in which it was used. Pairwise comparison of FEIBA and the control preparation for bleeding in the same joint or muscle showed a significantly better result with FEIBA (P = 0.0085). Joint mobility after the use of FEIBA was significantly improved (P = 0.006). There was a high incidence of hepatitis (three of the 15 patients) and of transient disturbances of liver function (nine of 15) during the 15-month observation period.
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Citations
Cited by
The hemophilias--from royal genes to gene therapy
Mannucci, P. M., & Tuddenham, E. G. D. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106073442307 · Cited by 1,110
The past and future of haemophilia: diagnosis, treatments, and its complications
Peyvandi, F., Garagiola, I., & Young, G. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01123-x · Cited by 505
Hoyer, L. W. (1994) · New England Journal of Medicine · doi:10.1056/nejm199401063300108 · Cited by 361
Darby, S. C., Keeling, D. M., Spooner, R. J. D., Wan Kan, S., Giangrande, P. L. F., Collins, P. W., Hill, F. G. H., & Hay, C. R. M. (2004) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2004.00710.x · Cited by 270
Hemophilia treatment in historical perspective: a review of medical and social developments
Rosendaal, F. R., Smit, C., & Briët, E. (1991) · Annals of Hematology · doi:10.1007/bf01714977 · Cited by 83
Metadata
- Authors
- Sjamsoedin, L. J. M., Heijnen, L., Mauser-Bunschoten, E. P., van Geijlswijk, J. L., van Houwelingen, H., van Asten, P., & Sixma, J. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1981-09-24
- Volume
- 305
- Issue
- 13
- Pages
- 717-721
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2734698134
- Cited by
- 304
- References
- 0
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Effect of Activated Prothrombin-Complex Concentrate (FEIBA) on Joint and Muscle Bleeding in Patients with Hemophilia A and Antibodies to Factor VIII: A Double-Blind Clinical Trial. https://app.cochat.ai/papers/10.1056/nejm198109243051301
- The paper
- Sjamsoedin, L. J. M., Heijnen, L., Mauser-Bunschoten, E. P., van Geijlswijk, J. L., van Houwelingen, H., van Asten, P., & Sixma, J. J. (1981). The Effect of Activated Prothrombin-Complex Concentrate (FEIBA) on Joint and Muscle Bleeding in Patients with Hemophilia A and Antibodies to Factor VIII: A Double-Blind Clinical Trial. New England Journal of Medicine. https://doi.org/10.1056/nejm198109243051301
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
