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Severe Acquired Immunodeficiency in Male Homosexuals, Manifested by Chronic Perianal Ulcerative Herpes Simplex Lesions
Abstract
Four homosexual men presented with gradually enlarging perianal ulcers, from which herpes simplex virus was cultured. Each patient had a prolonged course characterized by eight loss, fever, and evidence of infection by other opportunistic microorganisms including cytomegalovirus, Pneumocystis carinii, and Candida albicans. Three patients died; Kaposi's sarcoma developed in the fourth. All were found to have depressed cell-mediated immunity, as evidenced by skin anergy, lymphopenia, and poor or absent responses to plant lectins and antigens in vitro. Natural-killer-cell activity directed against target cells infected with herpes simplex virus was depressed in all patients. The absence of a history of recurrent infections or of histologic evidence of lymphoproliferative or other neoplastic diseases suggests that the immune defects were acquired.
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Citations
Cited by
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Ruterbusch, M., Pruner, K. B., Shehata, L., & Pepper, M. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-103019-085803 · Cited by 550
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.
Celum, C., Wald, A., Lingappa, J. R., Magaret, A. S., Wang, R. S., Mugo, N., Mujugira, A., Baeten, J. M., Mullins, J. I., Hughes, J. P., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0904849 · Cited by 524
Murray, H. W., Rubin, B. Y., Masur, H., & Roberts, R. B. (1984) · New England Journal of Medicine · doi:10.1056/nejm198404053101404 · Cited by 513
Hayashi, K., Nakano, T., Hashimoto, M., Kanekiyo, K., & Hayashi, T. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2007.10.017 · Cited by 247
Risk factors for Kaposi's sarcoma in homosexual men
Marmor, M., Laubenstein, L., William, D., Friedman-Kien, A., Byrum, R. D., D'Onofrio, S., & Dubin, N. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92275-9 · Cited by 238
Metadata
- Authors
- Siegal, F. P., Lopez, C., Hammer, G. S., Brown, A. E., Kornfeld, S. J., Gold, J., Hassett, J., Hirschman, S. Z., Cunningham-Rundles, C., Adelsberg, B. R., Parham, D. M., Siegal, M., Cunningham-Rundles, S., & Armstrong, D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1981-12-10
- Volume
- 305
- Issue
- 24
- Pages
- 1439-1444
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2316646354
- Cited by
- 1,246
- References
- 0
- FWCI
- 142.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Severe Acquired Immunodeficiency in Male Homosexuals, Manifested by Chronic Perianal Ulcerative Herpes Simplex Lesions. https://app.cochat.ai/papers/10.1056/nejm198112103052403
- The paper
- Siegal, F. P., Lopez, C., Hammer, G. S., Brown, A. E., Kornfeld, S. J., Gold, J., Hassett, J., Hirschman, S. Z., Cunningham-Rundles, C., Adelsberg, B. R., Parham, D. M., Siegal, M., Cunningham-Rundles, S., & Armstrong, D. (1981). Severe Acquired Immunodeficiency in Male Homosexuals, Manifested by Chronic Perianal Ulcerative Herpes Simplex Lesions. New England Journal of Medicine. https://doi.org/10.1056/nejm198112103052403
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
