The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Impaired Production of Lymphokines and Immune (Gamma) Interferon in the Acquired Immunodeficiency Syndrome
Abstract
To examine the cellular immune defect that predisposes patients with the acquired immunodeficiency syndrome (AIDS) to opportunistic infections, we tested T lymphocytes from 16 patients for the capacity to secrete macrophage-activating products (lymphokines) including gamma interferon. Mononuclear cells from 10 of 11 patients did not generate an effective lymphokine in response to mitogen, and 11 of 16 produced subnormal levels of gamma interferon (less than 300 U per milliliter). In addition, upon stimulation with specific microbial antigen, cells from none of 14 patients generated active lymphokines, and cells from 13 to 14 completely failed to secrete gamma interferon. However, the antimicrobial function of monocytes from the patients was intact, and once stimulated with normal lymphokines or gamma interferon alone, macrophages derived from patients' monocytes responded with enhanced and effective intracellular antimicrobial activity. These results suggest that impaired lymphokine production may predispose patients with AIDS to opportunistic infections, and they provide a rationale for using gamma interferon as immunotherapy.
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Cites
Gottlieb, M. S., Schroff, R., Schanker, H. M., Weisman, J. D., Fan, P. T., Wolf, R. A., & Saxon, A. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112103052401 · Cited by 2,728
Nathan, C. F., Murray, H. W., Wiebe, M. E., & Rubin, B. Y. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.670 · Cited by 1,962
Self-citationMasur, H., Michelis, M. A., Greene, J. B., Onorato, I., Vande Stouwe, R. A., Holzman, R. S., Wormser, G., Brettman, L., Lange, M., Murray, H. W., et al. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112103052402 · Cited by 1,434
Self-citationSiegal, F. P., Lopez, C., Hammer, G. S., Brown, A. E., Kornfeld, S. J., Gold, J., Hassett, J., Hirschman, S. Z., Cunningham-Rundles, C., Adelsberg, B. R., et al. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112103052403 · Cited by 1,246
Regulation of the immune response by prostaglandins
Goodwin, J. S., & Webb, D. R. (1980) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(80)90024-0 · Cited by 768
Expression of human immune interferon cDNA in E. coli and monkey cells
Gray, P. W., Leung, D. W., Pennica, D., Yelverton, E., Najarian, R., Simonsen, C. C., Derynck, R., Sherwood, P. J., Wallace, D. M., Berger, S. L., et al. (1982) · Nature · doi:10.1038/295503a0 · Cited by 689
The functional relationship of the interleukins.
Smith, K. A., Lachman, L. B., Oppenheim, J. J., & Favata, M. F. (1980) · The Journal of experimental medicine · doi:10.1084/jem.151.6.1551 · Cited by 653
The Macrophage as an Effector Cell
Nathan, C. F., Murray, H. W., & Cohn, Z. A. (1980) · New England Journal of Medicine · doi:10.1056/nejm198009113031106 · Cited by 621
Self-citationRecombinant interferon-gamma increases HLA-DR synthesis and expression.
Basham, T. Y., & Merigan, T. C. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.4.1492 · Cited by 575
Antigen presentation: comments on its regulation and mechanism.
Unanue, E. R., Beller, D. I., Lu, C. Y., & Allen, P. M. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.132.1.1 · Cited by 498
Cited by
Role of Microglia in Central Nervous System Infections
Rock, R. B., Gekker, G., Hu, S., Sheng, W. S., Cheeran, M., Lokensgard, J. R., & Peterson, P. K. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.942-964.2004 · Cited by 723
Johnston, R. B. (1988) · New England Journal of Medicine · doi:10.1056/nejm198803243181205 · Cited by 699
Metadata
- Authors
- Murray, H. W., Rubin, B. Y., Masur, H., & Roberts, R. B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-04-05
- Volume
- 310
- Issue
- 14
- Pages
- 883-889
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2334923455
- Cited by
- 513
- References
- 27
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Murray, H. W., Rubin, B. Y., Masur, H., & Roberts, R. B. (1984). Impaired Production of Lymphokines and Immune (Gamma) Interferon in the Acquired Immunodeficiency Syndrome. New England Journal of Medicine. https://doi.org/10.1056/nejm198404053101404
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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