Risk factors for Kaposi's sarcoma in homosexual men
Abstract
An investigation of 20 homosexual men with histologically confirmed Kaposi's sarcoma and 40 controls revealed significant associations between Kaposi's sarcoma and use of a number of drugs (amyl nitrite, ethyl chloride, cocaine, phencyclidine, methaqualone, and amphetamine), history of mononucleosis, and sexual activity in the year before onset of the disease. Patients with Kaposi's sarcoma also reported substantially higher rates of sexually transmitted infections than did controls. Multivariate analysis indicated independent significant associations for amyl nitrite and sexual activity and showed use of phencyclidine, methaqualone, and ethyl chloride to be non-significant. Evaluated at the median exposure for patients, the analysis yielded risk-ratio estimates of 12.3 for amyl nitrite (95% confidence limits 4.2, 35.8) and 2.0 for sexual activity (95% confidence limits 1.3, 3.1).
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Inhalant organic nitrites are epidemiologically linked to an increased risk of Kaposi's sarcoma.
“and are epidemiologically linked to an increased risk of Kaposi’s sarcoma [257, 258].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [258]
Inhalant organic nitrites (e.g. isobutyl nitrite) enhance tumor growth rate in mice.
“Inhalant organic nitrites (e.g. isobutyl nitrite) have been shown to enhance tumor growth rate in mice”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [258]
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Davey Smith, G., Phillips, A. N., & Neaton, J. D. (1992) · The Lancet · doi:10.1016/0140-6736(92)92242-8 · Cited by 149 · see citing works
Inorganic nitrite therapy: historical perspective and future directions
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- Authors
- Marmor, M., Laubenstein, L., William, D., Friedman-Kien, A., Byrum, R. D., D'Onofrio, S., & Dubin, N.
- Affiliations
- Columbia University Irving Medical Center (US)
- ORCID
- Marmor, Michael
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1982-05
- Volume
- 319
- Issue
- 8281
- Pages
- 1083-1087
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2039438273
- Cited by
- 238
- References
- 20
- Citations by year
- 2024: 2 · 2022: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 2 · 2013: 1
- FWCI
- 21.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Keywords
- Kaposi's sarcoma, gay men, risk factors, amyl nitrite, sexual activity, sexually transmitted infections, cocaine, phencyclidine, methaqualone, ethyl chloride, amphetamine, mononucleosis, drug use
- MeSH terms
- Adult, Amyl Nitrite, Disease Outbreaks, Dose-Response Relationship, Drug, Homosexuality, Humans, Immunosuppression Therapy, Male, Middle Aged, New York City, Risk, Sarcoma, Kaposi, Substance-Related Disorders
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