The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Decreased Coronary Reserve: A Mechanism for Angina Pectoris in Patients with Aortic Stenosis and Normal Coronary Arteries
Abstract
The pathogenesis of angina pectoris in patients with aortic stenosis and normal coronary arteries remains uncertain. Using a specially designed Doppler probe, we measured the maximal velocity of coronary blood flow in the left-anterior descending coronary artery at the time of elective open-heart surgery in 14 patients with aortic stenosis and left ventricular hypertrophy (13 had angina) and in 8 controls without left ventricular hypertrophy. The ratio peak velocity of coronary blood flow, after a 20-second occlusion, to resting velocity was decreased by more than 50 per cent (P less than 0.05) in the patients with aortic stenosis. In 7 of the patients this ratio was decreased by more than 75 per cent. Studies of the velocity of coronary blood flow in vessels perfusing the right ventricle in these patients showed only mild abnormalities. These data demonstrate a selective and marked decrease in coronary reserve to the hypertrophied left ventricle in patients with severe aortic stenosis. The impairment in coronary reserve is probably an important contributor to the pathogenesis of angina pectoris in these patients.
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Citations
Cites
Experimental Subendocardial Ischemia in Dogs with Normal Coronary Arteries
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Heart failure from the point of view of quantitative anatomy∗
Linzbach, A. J. (1960) · The American Journal of Cardiology · doi:10.1016/0002-9149(60)90084-9 · Cited by 722
An ultrasonic pulsed Doppler system for measuring blood flow in small vessels.
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Ventricular function and coronary hemodynamics in hypertensive heart disease
Strauer, B.-E. (1979) · The American Journal of Cardiology · doi:10.1016/0002-9149(79)90235-2 · Cited by 352
Effect of renal hypertension and left ventricular hypertrophy on the coronary circulation in dogs.
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Self-citationCoronary flow studies in patients with left ventricular hypertrophy of the hypertensive type
Pichard, A. D., Gorlin, R., Smith, H., Ambrose, J. A., & Meller, J. (1981) · The American Journal of Cardiology · doi:10.1016/0002-9149(81)90537-3 · Cited by 188
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Myocardial Blood Flow Distribution in Concentric Left Ventricular Hypertrophy
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Myocardial reactive hyperemia in the unanesthetized dog
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Cited by
Carabello, B. A., & Paulus, W. J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60211-7 · Cited by 818
Rakusan, K., Flanagan, M. F., Geva, T., Southern, J., & Van Praagh, R. (1992) · Circulation · doi:10.1161/01.cir.86.1.38 · Cited by 327
Rajappan, K., Rimoldi, O. E., Camici, P. G., Bellenger, N. G., Pennell, D. J., & Sheridan, D. J. (2003) · Circulation · doi:10.1161/01.cir.0000074211.28917.31 · Cited by 215
Survival after valve replacement for aortic stenosis: Implications for decision making
Mihaljevic, T., Nowicki, E. R., Rajeswaran, J., Blackstone, E. H., Lagazzi, L., Thomas, J., Lytle, B. W., & Cosgrove, D. M. (2008) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.12.042 · Cited by 208
Julius, B. K., Spillmann, M., Vassalli, G., Villari, B., Eberli, F. R., & Hess, O. M. (1997) · Circulation · doi:10.1161/01.cir.95.4.892 · Cited by 159
Metadata
- Authors
- Marcus, M. L., Doty, D. B., Hiratzka, L. F., Wright, C. B., & Eastham, C. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-11-25
- Volume
- 307
- Issue
- 22
- Pages
- 1362-1366
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337043813
- Cited by
- 580
- References
- 10
- FWCI
- 15.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Decreased Coronary Reserve: A Mechanism for Angina Pectoris in Patients with Aortic Stenosis and Normal Coronary Arteries. https://app.cochat.ai/papers/10.1056/nejm198211253072202
- The paper
- Marcus, M. L., Doty, D. B., Hiratzka, L. F., Wright, C. B., & Eastham, C. L. (1982). Decreased Coronary Reserve: A Mechanism for Angina Pectoris in Patients with Aortic Stenosis and Normal Coronary Arteries. New England Journal of Medicine. https://doi.org/10.1056/nejm198211253072202
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
