The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Differential Inhibition by Aspirin of Vascular and Platelet Prostaglandin Synthesis in Atherosclerotic Patients
Abstract
We studied the ability of a single oral dose of aspirin to inhibit prostacyclin synthesis by human arterial and venous tissue and to inhibit thromboxane A2 synthesis by platelets in 70 patients who were undergoing aortocoronary bypass. A dose of 40, 80, or 325 mg of aspirin was administered 12 to 16 hours before surgery. The generation of thromboxane in serum--which provides an estimate of platelet thromboxane production--was reduced from the control value by 77, 95, and 99 per cent after single doses of 40, 80, and 325 mg of aspirin, respectively. By contrast, prostacyclin production in aortic tissue that was removed at operation was reduced by only 35, 38, and 75 per cent, respectively, in response to these doses. Production of prostacyclin in saphenous-vein tissue (not tested after 40 mg of aspirin) fell only slightly and not significantly after 80 mg but was reduced by 85 per cent after 325 mg. These findings indicate that a low dose of aspirin (40 to 80 mg) can largely inhibit platelet aggregation and thromboxane synthesis but has much less effect on prostacyclin production in arterial and venous endothelium.
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Citations
Cites
Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets
SMITH, J. B., & WILLIS, A. L. (1971) · Nature New Biology · doi:10.1038/newbio231235a0 · Cited by 1,521
Acetylation of prostaglandin synthase by aspirin.
Roth, G. J., Stanford, N., & Majerus, P. W. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.8.3073 · Cited by 1,009
Patrignani, P., Filabozzi, P., & Patrono, C. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110576 · Cited by 937
Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects
Patrono, C., Ciabattoni, G., Pinca, E., Pugliese, F., Castrucci, G., De Salvo, A., Satta, M. A., & Peskar, B. A. (1980) · Thrombosis Research · doi:10.1016/0049-3848(80)90066-3 · Cited by 651
A Randomized, Controlled Trial of Aspirin in Persons Recovered From Myocardial Infarction
(1980) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1980.03300330019023 · Cited by 565
Chesebro, J. H., Clements, I. P., Fuster, V., Elveback, L. R., Smith, H. C., Bardsley, W. T., Frye, R. L., Holmes, D. R., Vlietstra, R. E., Pluth, J. R., et al. (1982) · New England Journal of Medicine · doi:10.1056/nejm198207083070201 · Cited by 537
(1980) · Circulation · doi:10.1161/01.cir.62.3.449 · Cited by 468
Moncada, S., & Korbut, R. (1978) · The Lancet · doi:10.1016/s0140-6736(78)91269-2 · Cited by 386
ASPIRIN AND SECONDARY MORTALITY AFTER MYOCARDIAL INFARCTION
Elwood, P. C., & Sweetnam, P. M. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92808-3 · Cited by 360
DIFFERENTIAL INHIBITION OF PROSTACYCLIN PRODUCTION AND PLATELET AGGREGATION BY ASPIRIN
Masotti, G., Poggesi, L., Galanti, G., Abbate, R., & Neri Serneri, G. G. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92334-1 · Cited by 284
Cited by
Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus
Williams, S. B., Cusco, J. A., Roddy, M.-A., Johnstone, M. T., & Creager, M. A. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00522-6 · Cited by 1,014
Patrono, C., Coller, B., Dalen, J. E., Fitz Gerald, G. A., Fuster, V., Gent, M., Hirsh, J., & Roth, G. (2001) · Chest · doi:10.1378/chest.119.1_suppl.39s · Cited by 963
Clinical Implications of Prostaglandin and Thromboxane A2Formation
Oates, J. A., FitzGerald, G. A., Branch, R. A., Jackson, E. K., Knapp, H. R., & Roberts, L. J. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809223191206 · Cited by 444
Panza, J. A., García, C. E., Kilcoyne, C. M., Quyyumi, A. A., & Cannon, R. O. (1995) · Circulation · doi:10.1161/01.cir.91.6.1732 · Cited by 428
IMPROVED AORTOCORONARY BYPASS PATENCY BY LOW-DOSE ASPIRIN (100 mg DAILY)
Lorenz, R. L., Weber, M., Kotzur, J., Theisen, K., Schacky, C. V., Meister, W., Reichardt, B., & Weber, P. C. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92446-2 · Cited by 320
Metadata
- Authors
- Weksler, B. B., Pett, S. B., Alonso, D., Richter, R. C., Stelzer, P., Subramanian, V., Tack-Goldman, K., & Gay, W. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-04-07
- Volume
- 308
- Issue
- 14
- Pages
- 800-805
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2092011140
- Cited by
- 448
- References
- 16
- FWCI
- 33.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Differential Inhibition by Aspirin of Vascular and Platelet Prostaglandin Synthesis in Atherosclerotic Patients. https://app.cochat.ai/papers/10.1056/nejm198304073081402
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- Weksler, B. B., Pett, S. B., Alonso, D., Richter, R. C., Stelzer, P., Subramanian, V., Tack-Goldman, K., & Gay, W. A. (1983). Differential Inhibition by Aspirin of Vascular and Platelet Prostaglandin Synthesis in Atherosclerotic Patients. New England Journal of Medicine. https://doi.org/10.1056/nejm198304073081402
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
