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Somatostatin

Reichlin, Seymour·1983·New England Journal of Medicine
DOI 10.1056/nejm198312153092406
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Abstract

DURING the course of efforts to determine the distribution of growth hormone–releasing factor (GHRF) in rat hypothalamus, a substance that inhibited growth hormone release was unexpectedly detected by Krulich et al.1 Their findings, reported in 1968, led them to hypothesize that the secretion of growth hormone from the pituitary was regulated by two different, interacting neurohumoral factors — one stimulatory, the other inhibitory — each under the control of the nervous system. Their hypothesis has since been substantiated by more specific methods. At about the same time, Hellman and Lernmark found a factor in extracts of pigeon pancreatic islets that . . .

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Metadata

Authors
Reichlin, S.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1983-12-15
Volume
309
Issue
24
Pages
1495-1501
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198312153092406
OpenAlex
W4239520211
Cited by
1,044
References
1
FWCI
25.12
Type
journal article
Language
en
Open access
closed

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Reichlin, S. (1983). Somatostatin. New England Journal of Medicine. https://doi.org/10.1056/nejm198312153092406

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