The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Effects of Sulindac and Ibuprofen in Patients with Chronic Glomerular Disease: Evidence for the Dependence of Renal Function on Prostacyclin
Abstract
We investigated whether the glomerular synthesis of prostacyclin modulates the renal blood flow and glomerular filtration rate in chronic glomerular disease. The urinary excretion of 6-keto-prostaglandin F1 alpha, a stable breakdown product of prostacyclin, was significantly (P less than 0.01) reduced in 20 women with chronic glomerular disease, as compared with 19 controls, whereas excretion of urinary prostaglandin E2 was unchanged. In 10 patients randomly assigned to one week of treatment with ibuprofen, excretion of urinary 6-keto-prostaglandin F1 alpha and prostaglandin E2 was reduced by 80 per cent, the level of serum creatinine was increased by 40 per cent, and creatinine and para-aminohippurate clearances were reduced by 28 and 35 per cent, respectively. The reduction of both clearances was inversely related (P less than 0.01) to the basal urinary excretion of 6-keto-prostaglandin F1 alpha but not of prostaglandin E2. No functional changes were detected in five healthy women, despite a similar suppression of renal prostacyclin synthesis by ibuprofen. In contrast, one week of treatment with sulindac did not affect renal prostacyclin synthesis or renal function in the other 10 patients, despite a marked inhibition of extrarenal cyclooxygenase activity. We conclude that in patients with mild impairment of renal function, the renal blood flow and glomerular filtration rate are critically dependent on prostacyclin production. In such patients sulindac may be a safe substitute for other nonsteroidal antiinflammatory drugs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gryglewski, R. J., Bunting, S., Moncada, S., Flower, R. J., & Vane, J. R. (1976) · Prostaglandins · doi:10.1016/0090-6980(76)90047-2 · Cited by 999
Brenner, R. J., Spring, D. B., Sebastian, A., McSherry, E. M., Genant, H. K., Palubinskas, A. J., & Morris, R. C. (1982) · New England Journal of Medicine · doi:10.1056/nejm198207223070403 · Cited by 700
Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects
Patrono, C., Ciabattoni, G., Pinca, E., Pugliese, F., Castrucci, G., De Salvo, A., Satta, M. A., & Peskar, B. A. (1980) · Thrombosis Research · doi:10.1016/0049-3848(80)90066-3 · Cited by 651
Self-citationProstaglandins: Modulators of Renal Function and Pressor Resistance in Chronic Liver Disease*
ZIPSER, R. D., HOEFS, J. C., SPECKART, P. F., ZIA, P. K., & HORTON, R. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-6-895 · Cited by 290
Prostacyclin is not a circulating hormone in man
Blair, I. A., Barrow, S. E., Waddell, K. A., Lewis, P. J., & Dollery, C. T. (1982) · Prostaglandins · doi:10.1016/0090-6980(82)90118-6 · Cited by 284
Estimated rate of prostacyclin secretion into the circulation of normal man.
FitzGerald, G. A., Brash, A. R., Falardeau, P., & Oates, J. A. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110373 · Cited by 269
Renal effects of drugs that inhibit prostaglandin synthesis
Dunn, M. J., & Zambraski, E. J. (1980) · Kidney International · doi:10.1038/ki.1980.179 · Cited by 269
The Effect of Indomethacin on Kidney Function and Plasma Renin Activity in Man
Donker, A. J. M., Arisz, L., Brentjens, J. R. H., van der Hem, G. K., & Hollemans, H. J. G. (1976) · Nephron · doi:10.1159/000180733 · Cited by 257
Reduction of renal function by newer nonsteroidal anti-inflammatory drugs
Kimberly, R. P., Bowden, R. E., Keiser, H. R., & Plötz, P. H. (1978) · The American Journal of Medicine · doi:10.1016/0002-9343(78)90520-x · Cited by 220
Reversible Acute Renal Failure from Combined Triamterene and Indomethacin
Favre, L., GLASSON, P., & VALLOTTON, M. B. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-96-3-317 · Cited by 140
Cited by
Renal Syndromes Associated with Nonsteroidal Antiinflammatory Drugs
Clive, D. M., & Stoff, J. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198403013100905 · Cited by 1,122
Perneger, T. V., Whelton, P. K., & Klag, M. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199412223312502 · Cited by 484
The clinical significance of inhibition of renal prostaglandin synthesis
Patrono, C., & Dunn, M. J. (1987) · Kidney International · doi:10.1038/ki.1987.164 · Cited by 296
Self-citationNonnarcotic Analgesic Use and the Risk of Hypertension in US Women
Dedier, J., Stampfer, M. J., Hankinson, S. E., Willett, W. C., Speizer, F. E., & Curhan, G. C. (2002) · Hypertension · doi:10.1161/01.hyp.0000035856.77718.da · Cited by 145
RADACK, K. L., DECK, C. C., & BLOOMFIELD, S. S. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-5-628 · Cited by 140
Metadata
- Authors
- Ciabattoni, G., Cinotti, G. A., Pierucci, A., Simonetti, B. M., Manzi, M., Pugliese, F., Barsotti, P., Pecci, G., Taggi, F., & Patrono, C.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-02-02
- Volume
- 310
- Issue
- 5
- Pages
- 279-283
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2003525499
- Cited by
- 329
- References
- 12
- FWCI
- 50.15
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effects of Sulindac and Ibuprofen in Patients with Chronic Glomerular Disease: Evidence for the Dependence of Renal Function on Prostacyclin. https://app.cochat.ai/papers/10.1056/nejm198402023100502
- The paper
- Ciabattoni, G., Cinotti, G. A., Pierucci, A., Simonetti, B. M., Manzi, M., Pugliese, F., Barsotti, P., Pecci, G., Taggi, F., & Patrono, C. (1984). Effects of Sulindac and Ibuprofen in Patients with Chronic Glomerular Disease: Evidence for the Dependence of Renal Function on Prostacyclin. New England Journal of Medicine. https://doi.org/10.1056/nejm198402023100502
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
