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The Effect of Indomethacin on Kidney Function and Plasma Renin Activity in Man
Abstract
125Iothalamate and 131I-hippuran clearances, sodium excretion and plasma renin activity (PRA) before and during indomethacin administration in an oral dose of 3 x 50 mg/day were studied in volunteers with a normal or reduced kidney function, as well on non-sodium-restricted as on sodium-restricted diet. Indomethacin induced a temporary sodium and water retention and a decrease in glomerular filtration rate. It also lowered PRA. The latter phenomenon did not depend on sodium retention and was present within 2 h after an oral dose of 50 mg. The results may be explained by indomethacin-induced inhibition of prostaglandin synthesis.
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Citations
Cited by
Renal Syndromes Associated with Nonsteroidal Antiinflammatory Drugs
Clive, D. M., & Stoff, J. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198403013100905 · Cited by 1,122
Clinical Implications of Prostaglandin and Thromboxane A2Formation
Oates, J. A., FitzGerald, G. A., Branch, R. A., Jackson, E. K., Knapp, H. R., & Roberts, L. J. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809223191206 · Cited by 444
Swan, S. K., Rudy, D. W., Lasseter, K. C., Ryan, C. F., Buechel, K. L., Lambrecht, L. J., Pinto, M. B., Dilzer, S. C., Obrda, O., Sundblad, K. J., et al. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-1-200007040-00002 · Cited by 339
Ciabattoni, G., Cinotti, G. A., Pierucci, A., Simonetti, B. M., Manzi, M., Pugliese, F., Barsotti, P., Pecci, G., Taggi, F., & Patrono, C. (1984) · New England Journal of Medicine · doi:10.1056/nejm198402023100502 · Cited by 329
Bjarnason, I., Williams, P., Smethurst, P., Peters, T. J., & Levi, A. J. (1986) · Gut · doi:10.1136/gut.27.11.1292 · Cited by 267
Metadata
- Authors
- Donker, A. J. M., Arisz, L., Brentjens, J. R. H., van der Hem, G. K., & Hollemans, H. J. G.
- Venue
- Nephron
- Publisher
- S. Karger AG
- Published
- 1976
- Volume
- 17
- Issue
- 4
- Pages
- 288-296
- ISSN
- 1660-8151 (ISSN-L)
- 1423-0186
- 0028-2766
- OpenAlex
- W2021689336
- Cited by
- 257
- References
- 0
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Effect of Indomethacin on Kidney Function and Plasma Renin Activity in Man. https://app.cochat.ai/papers/10.1159/000180733
- The paper
- Donker, A. J. M., Arisz, L., Brentjens, J. R. H., van der Hem, G. K., & Hollemans, H. J. G. (1976). The Effect of Indomethacin on Kidney Function and Plasma Renin Activity in Man. Nephron. https://doi.org/10.1159/000180733
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
