The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The Bronchoconstrictor Effect of Inhaled Prostaglandin D2 in Normal and Asthmatic Men
Abstract
Although prostaglandin D2 is the most abundant prostanoid generated by human lung mast cells and causes bronchoconstriction in animals, its effects have not been studied in human beings. We have compared the effects of inhaled prostaglandin D2 and prostaglandin F2 alpha on specific airway conductance in seven normal subjects and seven patients with mild allergic asthma. In dose-response studies in normal subjects, prostaglandin D2 caused a significant (20 +/- 6 per cent) fall in specific airway conductance after the two highest concentrations (250 and 500 micrograms per milliliter), whereas prostaglandin F2 alpha had no effect. In the asthmatic subjects, both prostaglandin D2 and prostaglandin F2 alpha caused a dose-related fall in specific airway conductance, starting at the lowest concentration of 4 micrograms per milliliter. Prostaglandin D2 was 3.5 times more potent than prostaglandin F2 alpha. In a single-dose study of both drugs (250 micrograms per milliliter), a minor fall in specific airway conductance occurred with prostaglandin D2 in the normal subjects, and a larger fall occurred with both drugs in the asthmatic subjects. Maximum effects were seen at three minutes: there was a 75 +/- 5 per cent fall with prostaglandin D2 and a 33 +/- 8 per cent fall with prostaglandin F2 alpha. These results suggest that prostaglandin D2 may be involved in the pathogenesis of bronchoconstriction in allergic asthma.
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Citations
Cites
Local Effects of Synthetic Leukotrienes (LTC4, LTD4, and LTB4) in Human Skin
Soter, N. A., Lewis, R. A., Corey, E. J., & Austen, K. F. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12531738 · Cited by 589
Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.
Lewis, R. A., Soter, N. A., Diamond, P. T., Austen, K. F., Oates, J. A., & Roberts, L. J. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.4.1627 · Cited by 584
Reproducibility and comparison of responses to inhaled histamine and methacholine.
Juniper, E. F., Frith, P. A., Dunnett, C., Cockcroft, D. W., & Hargreave, F. E. (1978) · Thorax · doi:10.1136/thx.33.6.705 · Cited by 541
Lewis, R. A., & Austen, K. F. (1981) · Nature · doi:10.1038/293103a0 · Cited by 473
Increased production of prostaglandin D2 in patients with systemic mastocytosis
Roberts, L. J., Sweetman, B. J., Lewis, R. A., Austen, K. F., & Oates, J. A. (1980) · New England Journal of Medicine · doi:10.1056/nejm198012113032405 · Cited by 423
Studies of the characterisation of prostanoid receptors: A proposed classification
Kennedy, I., Coleman, R. A., Humphrey, P. P. A., et al. (1982) · Prostaglandins · doi:10.1016/0090-6980(82)90036-3 · Cited by 305
Effects of Leukotriene D on the Airways in Asthma
Griffin, M. P., Weiss, J. W., Leitch, A. G., McFadden, E. R., Corey, E. J., Austen, K. F., & Drazen, J. M. (1983) · New England Journal of Medicine · doi:10.1056/nejm198302243080807 · Cited by 284
Prostaglandin D2 inhibits the aggregation of human platelets
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INFLAMMATORY EFFECTS OF PROSTAGLANDIN D2 IN RAT AND HUMAN SKIN
FLOWER, R. J., HARVEY, E. A., & KINGSTON, W. P. (1976) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1976.tb07446.x · Cited by 195
Bronchopulmonary and cardiovascular effects of prostaglandin D2 in the dog
Wasserman, M. A., DuCharme, D. W., Griffin, R. L., et al. (1977) · Prostaglandins · doi:10.1016/0090-6980(77)90007-7 · Cited by 110
Cited by
Galli, S. J. (2000) · Current Opinion in Hematology · doi:10.1097/00062752-200001000-00007 · Cited by 521
Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
Pettipher, R., Hansel, T. T., & Armer, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2266 · Cited by 317
Mediators of immediate hypersensitivity reactions
Serafin, W. E., & Austen, K. F. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707023170106 · Cited by 256
Airway injury as a mechanism for exercise-induced bronchoconstriction in elite athletes
Anderson, S. D., & Kippelen, P. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.05.001 · Cited by 237
Bochenek, G. (2004) · Thorax · doi:10.1136/thx.2003.013573 · Cited by 106
Metadata
- Authors
- Hardy, C. C., Robinson, C., Tattersfield, A. E., & Holgate, S. T.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-07-26
- Volume
- 311
- Issue
- 4
- Pages
- 209-213
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2323764868
- Cited by
- 316
- References
- 12
- FWCI
- 21.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Bronchoconstrictor Effect of Inhaled Prostaglandin D2 in Normal and Asthmatic Men. https://app.cochat.ai/papers/10.1056/nejm198407263110401
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- Hardy, C. C., Robinson, C., Tattersfield, A. E., & Holgate, S. T. (1984). The Bronchoconstrictor Effect of Inhaled Prostaglandin D2 in Normal and Asthmatic Men. New England Journal of Medicine. https://doi.org/10.1056/nejm198407263110401
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
