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Reproducibility and comparison of responses to inhaled histamine and methacholine.
Open accessAbstract
The efficiency of a standardised inhalation test procedure was studied by examining the reproducibility of responses to histamine and methacholine. In addition, the responses to the two agents were compared. Each set of duplicate tests was carried out on a separate day within one week, and all factors known or presumed to influence responses were carefully controlled. The results were expressed as the provocative concentration of the agent causing a 20% fall in forced expired volume in one second (PC20). Responses to histamine and methacholine were highly reproducible (coefficients of determination [r2] = 0.994 and 0.990 respectively). Responsiveness to histamine correlated closely with responsiveness to methacholine (r2 = 0.85). There was a small but significant cumulative dose effect with methacholine (P less than 0.01) but not with histamine. Side effects of throat irritation, flushing, and headache were more frequent with histamine than methacholine, and were dose-related. The high level of reproducibility indicates the efficiency of the test procedure. The similar severity of effects by agents with different mechanisms of action suggests that the primary cause of non-specific bronchial hyperreactivity lies at the level of bronchial smooth muscle.
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Cited by
Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults
Sterk, P. J., Fabbri, L. M., Quanjer, P. H., Cockcroft, D. W., O'Byrne, P. M., Anderson, S. D., Juniper, E. F., & Malo, J.-L. (1993) · European Respiratory Journal · doi:10.1183/09041950.053s1693 · Cited by 1,049
Self-citationMeasuring Quality of Life in Asthma
Juniper, E. F., Guyatt, G. H., Ferrie, P. J., & Griffith, L. E. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.4.832 · Cited by 887
Self-citationIdentification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
McIntire, J. J., Umetsu, S. E., Akbari, O., Potter, M., Kuchroo, V. K., Barsh, G. S., Freeman, G. J., Umetsu, D. T., & DeKruyff, R. H. (2001) · Nature Immunology · doi:10.1038/ni739 · Cited by 501
Varney, V. A., Gaga, M., Frew, A. J., Aber, V. R., Kay, A. B., & Durham, S. R. (1991) · BMJ · doi:10.1136/bmj.302.6771.265 · Cited by 384
Watson, W. T. A., Becker, A. B., & Simons, F. E. R. (1993) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(93)90301-u · Cited by 336
Metadata
- Authors
- Juniper, E. F., Frith, P. A., Dunnett, C., Cockcroft, D. W., & Hargreave, F. E.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 1978-12-01
- Volume
- 33
- Issue
- 6
- Pages
- 705-710
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W1995553664
- Cited by
- 541
- References
- 0
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Juniper, E. F., Frith, P. A., Dunnett, C., Cockcroft, D. W., & Hargreave, F. E. (1978). Reproducibility and comparison of responses to inhaled histamine and methacholine. Thorax. https://doi.org/10.1136/thx.33.6.705
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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