The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Relative Contributions of Aging and Estrogen Deficiency to Postmenopausal Bone Loss
Abstract
Debate continues on whether aging or estrogen deficiency is the more important determinant of postmenopausal bone loss. We compared 14 women who had undergone oophorectomy during young adulthood, 14 normal perimenopausal women, and 14 normal postmenopausal women (mean ages, 54, 52, and 73 years, respectively; mean duration of estrogen deficiency, 22, 0.3, and 22 years, respectively). Bone mineral density was assessed by single-photon and dual-photon absorptiometry. As compared with the perimenopausal group, the other two groups had significantly lower bone mineral density at the midradius, femoral neck, femoral intertrochanteric area, and lumbar spine (-15 per cent, -25 per cent, -16 per cent, and -23 per cent, respectively, in the oophorectomized group and -18 per cent, -28 per cent, -26 per cent, and -23 per cent, respectively, in the postmenopausal group). Because bone loss in the oophorectomized group (differing from the perimenopausal group in menopausal status but not in age) was almost as great as in the postmenopausal group (differing in both characteristics), we suggest that estrogen deficiency, and not aging, may be the predominant cause of bone loss occurring during the first two decades after natural menopause.
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Citations
Cites
Prevention of spinal osteoporosis in oophorectomised women
Lindsay, R., Hart, D. M., Forrest, C., & Baird, C. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92592-1 · Cited by 706
Cited by
Pacifici, R., Brown, C., Puscheck, E., Friedrich, E., Slatopolsky, E., Maggio, D., McCracken, R., & Avioli, L. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.12.5134 · Cited by 555
Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release.
Pacifici, R., Rifas, L., McCracken, R., Vered, I., McMurtry, C., Avioli, L. V., & Peck, W. A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2398 · Cited by 375
Wüster, C., Abs, R., Bengtsson, B.-Å., Bennmarker, H., Feldt-Rasmussen, U., Hernberg-Ståhl, E., Monson, J. P., Westberg, B., & Wilton, P. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.2.398 · Cited by 267
Longitudinal Association between Sex Hormone Levels, Bone Loss, and Bone Turnover in Elderly Men
Gennari, L., Merlotti, D., Martini, G., Gonnelli, S., Franci, B., Campagna, S., Lucani, B., Dal Canto, N., Valenti, R., Gennari, C., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030736 · Cited by 235
Thyroid Hormone Diseases and Osteoporosis
Delitala, A. P., Scuteri, A., & Doria, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041034 · Cited by 220
Bone loss in relation to menopause: a prospective study during 16 years
Ahlborg, H. G., Johnell, O., Nilsson, B. E., Jeppsson, S., Rannevik, G., & Karlsson, M. K. (2001) · Bone · doi:10.1016/s8756-3282(00)00451-8 · Cited by 147
Estrogen Deficiency, Postmenopausal Osteoporosis, and Age-Related Bone Loss
Khosla, S., & Pacifici, R. (2013) · Osteoporosis · doi:10.1016/b978-0-12-415853-5.00046-7 · Cited by 31
Takamura, Y., Miyauchi, A., Yabuta, T., Kihara, M., Ito, Y., & Miya, A. (2013) · World Journal of Surgery · doi:10.1007/s00268-013-2207-2 · Cited by 26
Metadata
- Authors
- Richelson, L. S., Wahner, H. W., Melton, L. J., & Riggs, B. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-11-15
- Volume
- 311
- Issue
- 20
- Pages
- 1273-1275
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2081028263
- Cited by
- 540
- References
- 1
- FWCI
- 30.68
- Type
- journal article
- Language
- en
- Open access
- closed
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