Prevention of spinal osteoporosis in oophorectomised women

Lindsay, R.; Hart, D.M.; Forrest, Colin; Baird, Clive

doi:10.1016/s0140-6736(80)92592-1

Cited by 706Bone health and osteoporosis researchMenopause: Health Impacts and TreatmentsEstrogen and related hormone effects

Prevention of spinal osteoporosis in oophorectomised women

Lindsay, R., Hart, D.M., Forrest, Colin, Baird, Clive·1980·The Lancet

DOI 10.1016/s0140-6736(80)92592-1

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Abstract

100 women who had taken part in a prospective controlled trial of oestrogen therapy for prevention of post-oophorectomy bone loss were reviewed after a median follow-up period of nine years. A significant reduction in height occurred among the placebo-treated group, but not in the group treated with mestranol (mean 23 x 3 micrograms/day). The placebo-treated group had a higher spine score, lower central vertebral height, and larger wedge-angle than the oestrogen group. Within each group none of these spinal morphometric changes correlated with changes in mineral content of metacarpal or radial bones as measured by photon absorptiometry or X-ray densitometry, although both peripheral and central measurements showed highly significant differences between groups. Oestrogen treatment, therefore, prevents against central, as well as peripheral, bone loss, and reduces the incidence of vertebral compression.

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Primary ovarian failure is associated with reduced bone mineral density and increased risk of fractures, and estrogen replacement protects against fractures.
“Primary ovarian failure is associated with reduced BMD and increased risk of fractures (154-156), and estrogen replacement protects against fractures (154,157,158).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [158]
The literature on primary ovarian failure supports the beneficial effects of estrogen on bone.
“Nonetheless, the literature on primary ovarian failure supports the beneficial effects of estrogen on bone.”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [158]

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Authors: Lindsay, R., Hart, D. M., Forrest, C., & Baird, C.
Affiliations: Helen Hayes Hospital (US)
Western Infirmary (GB)
ORCID: Lindsay, R.
Venue: The Lancet
Publisher: Elsevier BV
Published: 1980-11
Volume: 316
Issue: 8205
Pages: 1151-1154
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(80)92592-1
OpenAlex: W2004236425
Cited by: 706
References: 16
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 9 · 2022: 3 · 2021: 3 · 2020: 10 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 7
FWCI: 29.81
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: spinal osteoporosis, oophorectomy, estrogen therapy, bone loss prevention, vertebral compression, vertebral body height, wedge angle, bone mineral density, metacarpal bones, radial bone, postmenopausal women
MeSH terms: Body Height, Body Weight, Castration, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Mestranol, Metacarpus, Osteoporosis, Radiography, Spinal Diseases, Spine

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Prevention of spinal osteoporosis in oophorectomised women

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