Cited by 219Acne and Rosacea Treatments and EffectsLipoproteins and Cardiovascular HealthLipid metabolism and disorders

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne.

Bershad, Susan, Rubinstein, Ardon, Paterniti, James R., Le, Ngoc-Anh, Poliak, Susana C., Heller, Bruce, Ginsberg, Henry N., Fleischmajer, Raul, Brown, W. Virgil·1985·New England Journal of Medicine

DOI 10.1056/nejm198510173131604

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Abstract

Abnormalities in plasma lipids are a recognized side effect of isotretinoin therapy for nodulocystic acne. We studied 60 patients during 20 weeks of isotretinoin therapy, to measure changes in plasma lipids and lipoproteins, to compare plasma lipid responses in men and women, and to determine whether there are alterations in levels of lipoprotein lipase or hepatic triglyceride lipase that could explain the development of isotretinoin-induced hypertriglyceridemia. Mean triglyceride levels rose in men and women, with maximum mean increases of 46.3 mg per deciliter (P less than 0.0001) and 52.3 mg per deciliter (P less than 0.002), respectively. The maximum level was reached by 4 weeks of therapy in men but not until the 12th week in women. Nine of 53 patients (17 per cent) completing 20 weeks of isotretinoin therapy acquired hypertriglyceridemia, with values of 200 to 600 mg per deciliter. Both men and women had significant increases in mean plasma levels of cholesterol and low-density-lipoprotein cholesterol and decreases in mean levels of high-density-lipoprotein cholesterol. There were no significant changes in mean levels of lipoprotein lipase or hepatic triglyceride lipase. Plasma lipid and lipoprotein levels returned to base line by eight weeks after discontinuation of the drug. If sustained over a long period, the change in the ratio of low-density-lipoprotein cholesterol to high-density-lipoprotein cholesterol that we observed, from 2.4 to 3.0 (P less than 0.0001), would predict an increased risk of cardiovascular disease.

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“[220] High doses of all-trans RA have been used to treat acne and reportedly cause hyperlipidemia and hepatotoxicity [224] ; the mechanism behind this effect may be that all-trans RA inhibits the transcriptional activation of CYP7A1 by the FXR/RXR dimer.”
Background
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BackgroundResult
Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris
Agamia, N., Mulla, K. F. E., Alsayed, N. M., Ghazala, R. A., Abdelmaksoud, R., Abdelmeniem, I. M., Talaat, I. M., Zaki, I. I., Sabah, R. M., & Melnik, B. C. (2022) · Archives of Dermatological Research · doi:10.1007/s00403-022-02508-y · Cited by 18
“In addition, isotretinoin-induced hypertriglyceridemia [99] is associated with increased plasma levels of apolipoprotein B100 in very low-density lipoprotein (VLDL) and low density lipoproteins (LDL) [100].”
Background
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“noticed that dyslipidemia occurs during isotretinoin therapy for acne, including increased cholesterol and low-density-lipoprotein cholesterol and decreased high-density-lipoprotein cholesterol in plasma [48].”
Background
Evaluation of the Atherogenic Risk of Isotretinoin-induced and Etretinate-induced Alterations of Lipoprotein Cholesterol Metabolism.
Melnik, B. C., Bros, U., & Plewig, G. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12468920 · Cited by 12
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Isotretinoin treatment of severe cystic acne in a heart transplant patient receiving cyclosporine: Consideration of drug interactions
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Background
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Isotretinoin for Acne
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EFFECT OF SYSTEMIC ADMINISTRATION OF ISOTRETINOIN ON BLOOD LIPIDS AND FATTY ACIDS IN ACNE PATIENTS
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Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgarisPreprint
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“A significant portion of patients with acne receiving isotretinoin (13-cis RA) treatment developed hypertriglyceridemia [21].”
Background
Mechanism of the slow induction of apolipoprotein A-I synthesis by retinoids in cynomolgus hepatocytes: involvement of retinoic acid and retinoid X receptors
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9-cis-Retinoic Acid Treatment Increases Serum Concentrations of α-Tocopherol in Former Smokers
Han, J., Liu, D. D., Lee, J. J., Kurie, J. M., Lotan, R., Hong, W. K., & Lee, H. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2074 · Cited by 5
“5 (20-135) 42 (20-136) Smoking quit years Mean F SD 10.”
ResultInfluential
Phase I study of tamibarotene monotherapy in pediatric and young adult patients with recurrent/refractory solid tumors
Nitani, C., Hara, J., Kawamoto, H., Taguchi, T., Kimura, T., Yoshimura, K., Hamada, A., Kitano, S., Hattori, N., Ushijima, T., et al. (2021) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-021-04271-9 · Cited by 4
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Clinical Evaluation for Genetic and Secondary Causes of Dyslipidemia
Stone, N. J. (2009) · Elsevier eBooks · doi:10.1016/b978-141605469-6.50016-0 · Cited by 4
Retinoid Therapy of Acne and Sebocyte-Related Disorders
Taylor, G. A., & Shalita, A. R. (2007) · Basic and clinical dermatology · doi:10.3109/9781420021189.006 · Cited by 4
A retrospective evaluation of acne patients treated with isotretinoin
Aksu, F. E. (2016) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20164567 · Cited by 4
Diseases of the Sebaceous Follicles
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Authors: Bershad, S., Rubinstein, A., Paterniti, J. R., Le, N.-A., Poliak, S. C., Heller, B., Ginsberg, H. N., Fleischmajer, R., & Brown, W. V.
Affiliations: Mount Sinai Health System (US)
ORCID: Le, Ngoc-Anh
Ginsberg, Henry N.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1985-10-17
Volume: 313
Issue: 16
Pages: 981-985
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198510173131604
OpenAlex: W2338210778
Cited by: 217
References: 24
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 9 · 2012: 12
FWCI: 12.35
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: isotretinoin, acne, hypertriglyceridemia, plasma lipids, lipoproteins, triglycerides, cholesterol, LDL cholesterol, HDL cholesterol, lipoprotein lipase, hepatic lipase, sex differences, cardiovascular risk, adverse drug reactions
MeSH terms: Acne Vulgaris, Adolescent, Adult, Cholesterol, Female, Humans, Lipase, Lipids, Lipoprotein Lipase, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Tretinoin, Triglycerides, Isotretinoin

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Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne.

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