The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Diagnosis of Disseminated Histoplasmosis by Detection of Histoplasma capsulatum Antigen in Serum and Urine Specimens
Abstract
The diagnosis of Histoplasma capsulatum infection by serologic testing for the presence of antibodies is limited by a high rate of false positive and false negative results and by the requirement that the patient have a normal immune response. We have developed a radioimmunoassay for the detection of H. capsulatum antigen in urine and serum specimens. Antigenuria was noted in 20 of 22 episodes of disseminated histoplasmosis that occurred in 16 patients, in 6 of 32 patients with self-limited infection, in 2 of 32 patients with cavitary histoplasmosis, and in 4 of 8 patients with a sarcoid-like illness caused by H. capsulatum. The detection of antigen in urine was reproducible in 38 of 41 (93 percent) retests of specimens. H. capsulatum antigen was also detected in the serum during 11 of the 22 episodes of disseminated histoplasmosis, in none of the 12 episodes of other types of histoplasmosis in patients with antigenuria, in 1 of the 33 patients with histoplasmosis who lacked the urinary antigen, and in none of the 50 controls. Antigenemia and antigenuria decreased after initiation of antifungal therapy and recurred in patients who had a relapse. We conclude that this radioimmunoassay for H. capsulatum antigen represents a useful new method for the rapid diagnosis of disseminated histoplasmosis.
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Citations
Cites
Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
HUNTER, W. M., & GREENWOOD, F. C. (1962) · Nature · doi:10.1038/194495a0 · Cited by 6,919
Histoplasmosis in immunosuppressed patients
Kauffman, C. A., Israel, K. S., Smith, J. W., White, A. C., Schwarz, J., & Brooks, G. F. (1978) · The American Journal of Medicine · doi:10.1016/0002-9343(78)90445-x · Cited by 236
Clinical and Laboratory Features of Disseminated Histoplasmosis During Two Large Urban Outbreaks
SATHAPATAYAVONGS, B., BATTEIGER, B. E., WHEAT, J., SLAMA, T. G., & WASS, J. L. (1983) · Medicine · doi:10.1097/00005792-198309000-00001 · Cited by 195
The Diagnostic Laboratory Tests for Histoplasmosis: Analysis of Experience in a Large Urban Outbreak
WHEAT, J., FRENCH, M. L. V., KÖHLER, R. B., ZIMMERMAN, S. E., SMITH, W. R., NORTON, J. A., EITZEN, H. E., SMITH, C. D., & SLAMA, T. G. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-97-5-680 · Cited by 180
Diagnosis of Cryptococcal Meningitis: Value of Immunologic Detection of Cryptococcal Antigen
Goodman, J. S., Kaufman, L., & Koenig, M. G. (1971) · New England Journal of Medicine · doi:10.1056/nejm197108192850804 · Cited by 160
Immunoglobulin M and G Histoplasmal Antibody Response in Histoplasmosis
Wheat, L. J., Kohler, R. B., French, M. L., Garten, M. L., Kleiman, M. B., Zimmerman, S. E., Schlech, W. F., Ho, J. L., WHITE, A. C., & Brahmi, Z. (1983) · American Review of Respiratory Disease · doi:10.1164/arrd.1983.128.1.65 · Cited by 54
Self-citationCerebrospinal Fluid Histoplasma Antibodies in Central Nervous System Histoplasmosis
Wheat, L. J., French, M., Batteiger, B., & Kohler, R. (1985) · Archives of Internal Medicine · doi:10.1001/archinte.1985.00360070115018 · Cited by 34
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Cited by
Histoplasmosis: a Clinical and Laboratory Update
Kauffman, C. A. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00027-06 · Cited by 1,200
A Multicenter Evaluation of Tests for Diagnosis of Histoplasmosis
Hage, C. A., Ribes, J. A., Wengenack, N. L., Baddour, L. M., Assi, M., McKinsey, D. S., Hammoud, K., Alapat, D., Babady, N. E., Parker, M., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir435 · Cited by 393
Self-citationImprovements in diagnosis of histoplasmosis.
Wheat, L. J. (2006) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.6.11.1207 · Cited by 172
Self-citationFungal Infections of the Genitourinary System
Wise, G. J., & Silver, D. A. (1993) · Journal of Urology · doi:10.1016/s0022-5347(17)36396-6 · Cited by 85
Metadata
- Authors
- Wheat, L. J., Kohler, R. B., & Tewari, R. P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1986-01-09
- Volume
- 314
- Issue
- 2
- Pages
- 83-88
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2341143195
- Cited by
- 331
- References
- 7
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wheat, L. J., Kohler, R. B., & Tewari, R. P. (1986). Diagnosis of Disseminated Histoplasmosis by Detection of Histoplasma capsulatum Antigen in Serum and Urine Specimens. New England Journal of Medicine. https://doi.org/10.1056/nejm198601093140205
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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