The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Continuous Intravenous Heparin Compared with Intermittent Subcutaneous Heparin in the Initial Treatment of Proximal-Vein Thrombosis
Abstract
We performed a randomized double-blind trial comparing continuous intravenous heparin with intermittent subcutaneous heparin in the initial treatment of 115 patients with acute proximal deep-vein thrombosis. Intermittent subcutaneous heparin as administered in this trial was inferior to continuous intravenous heparin in preventing recurrent venous thromboembolism. The subcutaneous heparin regimen induced an initial anticoagulant response below the target therapeutic range in the majority of patients and resulted in a high frequency of recurrent venous thromboembolism (11 of 57 patients, 19.3 percent), which was virtually confined to patients with a subtherapeutic anticoagulant response. In contrast, continuous intravenous heparin induced a therapeutic anticoagulant response in the majority of patients and a low frequency of recurrent events (3 of 58 patients, 5.2 percent; P = 0.024); the recurrences were limited to patients with an initial subtherapeutic anticoagulant response. The results of this trial establish the efficacy of intravenous heparin in the treatment of proximal venous thrombosis and suggest a relation between the effectiveness of heparin and the levels of anticoagulation achieved; such a relation could explain the observed failure of the subcutaneous regimen.
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Cites
Sackett, D. L. (1979) · Journal of Chronic Diseases · doi:10.1016/0021-9681(79)90012-2 · Cited by 2,075
Self-citationRoentgen Diagnosis of Venous Thrombosis in the Leg
Rabinov, K. (1972) · Archives of Surgery · doi:10.1001/archsurg.1972.04180020014004 · Cited by 740
Different Intensities of Oral Anticoagulant Therapy in the Treatment of Proximal-Vein Thrombosis
Hull, R., Hirsh, J., Jay, R., Carter, C., England, C., Gent, M., Turpie, A. G. G., McLoughlin, D., Dodd, P., Thomas, M., et al. (1982) · New England Journal of Medicine · doi:10.1056/nejm198212303072704 · Cited by 728
Self-citationBasu, D., Gallus, A., Hirsh, J., & Cade, J. (1972) · New England Journal of Medicine · doi:10.1056/nejm197208172870703 · Cited by 661
Self-citationWarfarin Sodium versus Low-Dose Heparin in the Long-Term Treatment of Venous Thrombosis
Hull, R., Delmore, T., Genton, E., Hirsh, J., Gent, M., Sackett, D., McLoughlin, D., & Armstrong, P. (1979) · New England Journal of Medicine · doi:10.1056/nejm197910183011602 · Cited by 604
Self-citationAdjusted Subcutaneous Heparin versus Warfarin Sodium in the Long-Term Treatment of Venous Thrombosis
Hull, R., Delmore, T., Carter, C., Hirsh, J., Genton, E., Gent, M., Turpie, G., & McLaughlin, D. (1982) · New England Journal of Medicine · doi:10.1056/nejm198201283060401 · Cited by 436
Self-citationManagement of Heparin Therapy: Controlled Prospective Trial
Salzman, E. W., Deykin, D., Shapiro, R. M., & Rosenberg, R. (1975) · New England Journal of Medicine · doi:10.1056/nejm197505152922002 · Cited by 435
HÆMORRHAGIC COMPLICATIONS OF HEPARIN THERAPY
Mant, M., Thong, K. L., Birtwhistle, R., O'Brien, B., Hammond, G., & Grace, M. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92388-1 · Cited by 242
Plasma heparin: a unique, practical, submicrogram-sensitive assay.
Et, Y., Wessler, S., & Butler, J. V. (1973) · PubMed · Cited by 235
The diagnosis of acute, recurrent, deep-vein thrombosis: a diagnostic challenge.
Hull, R. D., Carter, C. J., Jay, R. M., Ockelford, P. A., Hirsch, J., Turpie, A. G., Zielinsky, A., Gent, M., & Powers, P. J. (1983) · Circulation · doi:10.1161/01.cir.67.4.901 · Cited by 218
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Cited by
Kearon (2012) · doi:10.1378/chest.11-2301 · Cited by 6,119
Antithrombotic Therapy for VTE Disease
Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., Bounameaux, H., Huisman, M., King, C. S., Morris, T. A., Sood, N., et al. (2016) · Chest · doi:10.1016/j.chest.2015.11.026 · Cited by 4,830
2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism
Authors/Task Force Members, Konstantinides, S. V., Torbicki, A., Agnelli, G., Danchin, N., Fitzmaurice, D., Galiè, N., Gibbs, J. S. R., Huisman, M. V., Humbert, M., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu283 · Cited by 3,128
Decousus, H., Leizorovicz, A., Parent, F., Page, Y., Tardy, B., Girard, P., Laporte, S., Faivre, R., Charbonnier, B., Barral, F.-G., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380701 · Cited by 1,702
Weitz, J. I., Hudoba, M., Massel, D., Maraganore, J., & Hirsh, J. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114723 · Cited by 1,123
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Metadata
- Authors
- Hull, R. D., Raskob, G. E., Hirsh, J., Jay, R. M., Leclerc, J. R., Geerts, W. H., Rosenbloom, D., Sackett, D. L., Anderson, C., Harrison, L., & Gent, M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1986-10-30
- Volume
- 315
- Issue
- 18
- Pages
- 1109-1114
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2073325230
- Cited by
- 722
- References
- 15
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Continuous Intravenous Heparin Compared with Intermittent Subcutaneous Heparin in the Initial Treatment of Proximal-Vein Thrombosis. https://app.cochat.ai/papers/10.1056/nejm198610303151801
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- Hull, R. D., Raskob, G. E., Hirsh, J., Jay, R. M., Leclerc, J. R., Geerts, W. H., Rosenbloom, D., Sackett, D. L., Anderson, C., Harrison, L., & Gent, M. (1986). Continuous Intravenous Heparin Compared with Intermittent Subcutaneous Heparin in the Initial Treatment of Proximal-Vein Thrombosis. New England Journal of Medicine. https://doi.org/10.1056/nejm198610303151801
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
