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Cited by 819

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

Hong, Waun Ki, Endicott, James, Itri, Loretta M., Doos, Wilhelm, Batsakis, John G., Bell, Richard, Fofonoff, Stephanie, Byers, Robert, Atkinson, E. Neely, Vaughan, Charles, Toth, Bela B., Kramer, Alan, Dimery, Isaiah W., Skipper, Paulette, Strong, Stuart·1986·New England Journal of Medicine
DOI 10.1056/nejm198612113152401
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Abstract

13-cis-Retinoic acid has been reported to be effective in treating oral leukoplakia. We randomly assigned 44 patients with this disease to receive 13-cis-retinoic acid (24 patients) or placebo (20), 1 to 2 mg per kilogram of body weight per day for three months, and followed them for six months. There were major decreases in the size of the lesions in 67 percent (16 patients) of those given the drug and in 10 percent (2 patients) of those given placebo (P = 0.0002); dysplasia was reversed in 54 percent (13 patients) of the drug group and in 10 percent (2 patients) of the placebo group (P = 0.01). The clinical response to the drug correlated with the histologic response in 56 percent (9 of 16) of the patients evaluated. Relapse occurred in 9 of 16 patients two to three months after treatment ended. The toxic effects of the drug were acceptable in all but two patients. Cheilitis, facial erythema, and dryness and peeling of the skin were common; conjunctivitis and hypertriglyceridemia also occurred. All adverse reactions could be reversed by reducing the dose or temporarily discontinuing the drug. We conclude that 13-cis-retinoic acid, even in short-term use, appears to be an effective treatment for oral leukoplakia and has an acceptable level of toxicity.

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Metadata

Authors
Hong, W. K., Endicott, J., Itri, L. M., Doos, W., Batsakis, J. G., Bell, R., Fofonoff, S., Byers, R., Atkinson, E. N., Vaughan, C., Toth, B. B., Kramer, A., Dimery, I. W., Skipper, P., & Strong, S.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1986-12-11
Volume
315
Issue
24
Pages
1501-1505
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198612113152401
OpenAlex
W2339318589
Cited by
819
References
11
FWCI
25.56
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: 13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia. https://app.cochat.ai/papers/10.1056/nejm198612113152401
The paper
Hong, W. K., Endicott, J., Itri, L. M., Doos, W., Batsakis, J. G., Bell, R., Fofonoff, S., Byers, R., Atkinson, E. N., Vaughan, C., Toth, B. B., Kramer, A., Dimery, I. W., Skipper, P., & Strong, S. (1986). 13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia. New England Journal of Medicine. https://doi.org/10.1056/nejm198612113152401

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.