The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Low Risk of Herpes Simplex Virus Infections in Neonates Exposed to the Virus at the Time of Vaginal Delivery to Mothers with Recurrent Genital Herpes Simplex Virus Infections
Abstract
We studied the risk of herpes simplex virus (HSV) infections in neonates exposed to HSV at the time of vaginal delivery to mothers with a history of recurrent genital HSV infections. None of 34 infants exposed to HSV type 2 acquired an HSV infection. On the basis of this sample, the 95 percent confidence limit for the theoretical maximum infection rate is 8 percent. Cord blood or blood obtained during the first two weeks of life was available from 33 of the 34 exposed, uninfected neonates. All 33 of the samples possessed demonstrable neutralizing antibody to HSV type 2, and 79 percent had titers above 1:20. These results were compared with those in a previously studied group of neonates with HSV infections; the latter infants were significantly less likely at the onset of symptoms to have demonstrable neutralizing antibody to HSV type 2 (P = 0.000148) or to have titers above 1:20 (P less than 0.00001). We conclude that given the low attack rate, empirical antiviral therapy is not warranted in all infants of mothers with recurrent genital HSV infection who are exposed to the virus in the birth canal. Our findings suggest that the presence and titer of neutralizing antibody to HSV contribute to the low attack rate.
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Citations
Cites
Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections
Lennette, E. H., Lennette, D. A., & Lennette, E. T. (1989) · Virtual Defense Library (Ministerio de Defensa) · Cited by 2,353
Infections with Herpes Simplex Viruses
Corey, L., & Spear, P. G. (1986) · New England Journal of Medicine · doi:10.1056/nejm198603133141105 · Cited by 778
The Natural History of Herpes Simplex Virus Infection of Mother and Newborn
Whitley, R. J., Nahmias, A. J., Visintine, A. M., Fleming, C. L., Alford, C. A., Yeager, A., Arvin, A., Haynes, R., Hilty, M., & Luby, J. (1980) · Pediatrics · doi:10.1542/peds.66.4.489 · Cited by 462
Self-citationArvin, A. M., Hensleigh, P. A., Prober, C. G., Au, D. S., Yasukawa, L. L., Wittek, A. E., Palumbo, P. E., Paryani, S. G., & Yeager, A. S. (1986) · New England Journal of Medicine · doi:10.1056/nejm198609253151303 · Cited by 219
Self-citationRelationship of Antibody to Outcome in Neonatal Herpes Simplex Virus Infections
Yeager, A. S., Arvin, A. M., Urbani, L. J., & Kemp, J. A. (1980) · Infection and Immunity · doi:10.1128/iai.29.2.532-538.1980 · Cited by 169
Self-citationArvin, A. M., Pollard, R. B., Rasmussen, L., et al. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109739 · Cited by 135
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Corey, L., Langenberg, A. G. M., Ashley, R., Sekulovich, R. E., Izu, A. E., Douglas, Jr., Handsfield, H. H., Warren, T., Marr, L., Tyring, S., et al. (1999) · JAMA · doi:10.1001/jama.282.4.331 · Cited by 490
Brown, Z. A., Benedetti, J., Ashley, R., Burchett, S., Selke, S., Berry, S., Vontver, L. A., & Corey, L. (1991) · New England Journal of Medicine · doi:10.1056/nejm199105023241804 · Cited by 473
Sexually transmitted diseases and adverse outcomes of pregnancy
Goldenberg, R. L., Andrews, W. W., Yuan, A. C., MacKay, H. T., & Louis, M. E. S. (1997) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30182-9 · Cited by 166
LaTourette, P. C., Awasthi, S., Desmond, A., Pardi, N., Cohen, G. H., Weissman, D., & Friedman, H. M. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.09.079 · Cited by 39
Metadata
- Authors
- Prober, C. G., Sollender, W. M., Yasukawa, L. L., Au, D. S., Yeager, A. S., & Arvin, A. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1987-01-29
- Volume
- 316
- Issue
- 5
- Pages
- 240-244
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2332559639
- Cited by
- 339
- References
- 6
- FWCI
- 17.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Low Risk of Herpes Simplex Virus Infections in Neonates Exposed to the Virus at the Time of Vaginal Delivery to Mothers with Recurrent Genital Herpes Simplex Virus Infections. https://app.cochat.ai/papers/10.1056/nejm198701293160503
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- Prober, C. G., Sollender, W. M., Yasukawa, L. L., Au, D. S., Yeager, A. S., & Arvin, A. M. (1987). Low Risk of Herpes Simplex Virus Infections in Neonates Exposed to the Virus at the Time of Vaginal Delivery to Mothers with Recurrent Genital Herpes Simplex Virus Infections. New England Journal of Medicine. https://doi.org/10.1056/nejm198701293160503
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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