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Cited by 272Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 17 of the 18 references it cites were found in a registry or an index.

Long-Term Growth in Juvenile Acquired Hypothyroidism:

Rivkees, Scott A., Bode, Hans H., Crawford, John D.·1988·New England Journal of Medicine
DOI 10.1056/nejm198803103181003
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Abstract

It has been suggested that complete catch-up growth is achieved with treatment in patients with juvenile acquired hypothyroidism. We tested this assumption by examining long-term growth in 18 girls (mean [+/- SD] age, 11.4 +/- 2.7 years; bone age, 6.2 +/- 3.1 years) and 6 boys (age, 10.6 +/- 4.7 years; bone age, 6.4 +/- 2.7 years) with severe primary hypothyroidism (serum thyroxine level 1.1 +/- 0.3 micrograms per deciliter [13 +/- 4 nmol per liter]). At diagnosis, heights were 4.04 +/- 0.5 and 3.15 +/- 0.4 SD below the mean heights for age of normal girls and boys, respectively. The patients were treated with levothyroxine (3.4 +/- 0.3 micrograms per kilogram of body weight per day) to maintain normal thyroid function. During the first 18 months of therapy, the children's skeletal maturation exceeded the maturation expected for their statural growth, regardless of whether or not they were undergoing pubertal development. Predictions of decreased adult height were based on these observations. At maturity, girls and boys stood approximately 2 SD below normal adult stature, at 149 +/- 5.0 cm and 168 +/- 5.1 cm, respectively. Heights at maturity were also lower than midparental heights (P less than 0.01) and lower than pre-illness standard-deviation scores for height (P less than 0.01). The deficit in adult stature was significantly related to the duration of hypothyroidism before treatment (P less than 0.01). We conclude that despite treatment, prolonged juvenile acquired hypothyroidism results in a permanent height deficit related to the duration of thyroxine deficiency before treatment.

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Research works printed but not linked: 5

  1. Hamill, 1977, Vital Health Stat [11], 165, 1
  2. Churchill E. Statistical consideration. In: Falkner F, ed. Human development. Philadelphia: W.B. Saunders, 1966:48.
  3. Tanner JM. Human growth standards: construction and use. In: Gedda L, Parisi P, eds. Auxology: human growth in health and disorder. London: Academic Press, 1978:109–21.
  4. Bucher, 1985, Helv Paediatr Acta, 40, 305
  5. Von Harnack, 1972, Eur J Pediatr, 112, 1

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Metadata

Authors
Rivkees, S. A., Bode, H. H., & Crawford, J. D.
Affiliations
Massachusetts General Hospital (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1988-03-10
Volume
318
Issue
10
Pages
599-602
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198803103181003
OpenAlex
W2326819552
Cited by
272
References
18
Citations by year
2026: 5 · 2025: 15 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 14 · 2019: 12 · 2018: 10 · 2017: 13 · 2016: 19 · 2015: 10 · 2014: 10 · 2013: 9 · 2012: 13
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
catch-up growth, levothyroxine therapy, adult height prediction, height deficit, skeletal maturation, bone age, pubertal development, mid-parental height
MeSH terms
Age Factors, Body Weight, Child, Female, Follow-Up Studies, Growth, Humans, Hypothyroidism, Male, Sexual Maturation, Thyroxine, Time Factors

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