Cited by 272Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormones

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Long-Term Growth in Juvenile Acquired Hypothyroidism:

Rivkees, Scott A., Bode, Hans H., Crawford, John D.·1988·New England Journal of Medicine

DOI 10.1056/nejm198803103181003

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Abstract

It has been suggested that complete catch-up growth is achieved with treatment in patients with juvenile acquired hypothyroidism. We tested this assumption by examining long-term growth in 18 girls (mean [+/- SD] age, 11.4 +/- 2.7 years; bone age, 6.2 +/- 3.1 years) and 6 boys (age, 10.6 +/- 4.7 years; bone age, 6.4 +/- 2.7 years) with severe primary hypothyroidism (serum thyroxine level 1.1 +/- 0.3 micrograms per deciliter [13 +/- 4 nmol per liter]). At diagnosis, heights were 4.04 +/- 0.5 and 3.15 +/- 0.4 SD below the mean heights for age of normal girls and boys, respectively. The patients were treated with levothyroxine (3.4 +/- 0.3 micrograms per kilogram of body weight per day) to maintain normal thyroid function. During the first 18 months of therapy, the children's skeletal maturation exceeded the maturation expected for their statural growth, regardless of whether or not they were undergoing pubertal development. Predictions of decreased adult height were based on these observations. At maturity, girls and boys stood approximately 2 SD below normal adult stature, at 149 +/- 5.0 cm and 168 +/- 5.1 cm, respectively. Heights at maturity were also lower than midparental heights (P less than 0.01) and lower than pre-illness standard-deviation scores for height (P less than 0.01). The deficit in adult stature was significantly related to the duration of hypothyroidism before treatment (P less than 0.01). We conclude that despite treatment, prolonged juvenile acquired hypothyroidism results in a permanent height deficit related to the duration of thyroxine deficiency before treatment.

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Authors: Rivkees, S. A., Bode, H. H., & Crawford, J. D.
Affiliations: Massachusetts General Hospital (US)
ORCID: Rivkees, Scott A.
Crawford, John D.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1988-03-10
Volume: 318
Issue: 10
Pages: 599-602
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198803103181003
OpenAlex: W2326819552
Cited by: 272
References: 18
Citations by year: 2026: 5 · 2025: 15 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 14 · 2019: 12 · 2018: 10 · 2017: 13 · 2016: 19 · 2015: 10 · 2014: 10 · 2013: 9 · 2012: 13
FWCI: 2.07
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: catch-up growth, levothyroxine therapy, adult height prediction, height deficit, skeletal maturation, bone age, pubertal development, mid-parental height
MeSH terms: Age Factors, Body Weight, Child, Female, Follow-Up Studies, Growth, Humans, Hypothyroidism, Male, Sexual Maturation, Thyroxine, Time Factors

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