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Prevalence of Patent Foramen Ovale in Patients with Stroke
Abstract
The cause of ischemic stroke in younger adults is undefined in as many as 35 percent of patients. We studied the prevalence of patent foramen ovale as detected by contrast echocardiography in a population of 60 adults under 55 years old with ischemic stroke and a normal cardiac examination. We compared the results with those in a control group of 100 patients. The prevalence of patent foramen ovale was significantly higher in the patients with stroke (40 percent) than in the control group (10 percent, P less than 0.001). Among the patients with stroke, the prevalence of patent foramen ovale was 21 percent in 19 patients with an identifiable cause of their stroke, 40 percent in 15 patients with no identifiable cause but a risk factor for stroke, such as mitral valve prolapse, migraine, or use of contraceptive agents, and 54 percent in 26 patients with no identifiable cause (P less than 0.10). These results suggest that because of the high prevalence of clinically latent venous thrombosis, paradoxical embolism through a patent foramen ovale may be responsible for stroke more often than is usually suspected.
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Citations
Cited by
Kernan, W. N., Ovbiagele, B., Black, H. R., Bravata, D. M., Chimowitz, M. I., Ezekowitz, M. D., Fang, M. C., Fisher, M., Furie, K. L., Heck, D. V., et al. (2014) · Stroke · doi:10.1161/str.0000000000000024 · Cited by 5,170
Meschia, J. F., Bushnell, C., Boden-Albala, B., Braun, L. T., Bravata, D. M., Chaturvedi, S., Creager, M. A., Eckel, R. H., Elkind, M. S. V., Fornage, M., et al. (2014) · Stroke · doi:10.1161/str.0000000000000046 · Cited by 2,650
Goldstein, L. B., Bushnell, C. D., Adams, R. J., Appel, L. J., Braun, L. T., Chaturvedi, S., Creager, M. A., Culebras, A., Eckel, R. H., Hart, R. G., et al. (2011) · Stroke · doi:10.1161/str.0b013e3181fcb238 · Cited by 1,306
Patent Foramen Ovale and Stroke
Homma, S., & Sacco, R. L. (2005) · Circulation · doi:10.1161/circulationaha.104.524371 · Cited by 435
Antithrombotic Therapy in Valvular Heart Disease
Salem, D. N., Hartnett Daudelin, D., Levine, H. J., Pauker, S. G., Eckman, M. H., & Riff, J. (2001) · Chest · doi:10.1378/chest.119.1_suppl.207s · Cited by 60
Metadata
- Authors
- Lechat, P., Mas, J. L., Lascault, G., Loron, P., Theard, M., Klimczac, M., Drobinski, G., Thomas, D., & Grosgogeat, Y.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1988-05-05
- Volume
- 318
- Issue
- 18
- Pages
- 1148-1152
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2326526061
- Cited by
- 1,657
- References
- 0
- FWCI
- 38.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Prevalence of Patent Foramen Ovale in Patients with Stroke. https://app.cochat.ai/papers/10.1056/nejm198805053181802
- The paper
- Lechat, P., Mas, J. L., Lascault, G., Loron, P., Theard, M., Klimczac, M., Drobinski, G., Thomas, D., & Grosgogeat, Y. (1988). Prevalence of Patent Foramen Ovale in Patients with Stroke. New England Journal of Medicine. https://doi.org/10.1056/nejm198805053181802
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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