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Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Abstract
IN this seminar we review recent studies suggesting that the central pathologic features of diabetic complications are caused by the hyperglycemia-accelerated formation of nonenzymatic advanced glycosylation end products in tissue. We will emphasize new research findings with important clinical implications, since older information is available in previously published reviews.1 , 2 Other biochemical mechanisms by which hyperglycemia may contribute to the development of diabetic complications are not discussed here, since they are comprehensively reviewed elsewhere.3 4 5 6 7 8 Differences between Early and Advanced Glycosylation ProductsThe central pathophysiologic features of diabetic vascular complications are an abnormal leakage of proteins from the circulation and a progressive . . .
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Cited by
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Grundy, S. M., Benjamin, I. J., Burke, G. L., Chait, A., Eckel, R. H., Howard, B. V., Mitch, W., Smith, S. C., & Sowers, J. R. (1999) · Circulation · doi:10.1161/01.cir.100.10.1134 · Cited by 2,698
Preeclampsia: an endothelial cell disorder
Roberts, J. M., Taylor, R. N., Musci, T. J., Rodgers, G. M., Hubel, C. A., & McLaughlin, M. K. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90665-0 · Cited by 1,859
Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness
Zieman, S. J., Melenovsky, V., & Kass, D. A. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000160548.78317.29 · Cited by 1,854
Metadata
- Authors
- Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1988-05-19
- Volume
- 318
- Issue
- 20
- Pages
- 1315-1321
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1998614770
- Cited by
- 2,511
- References
- 0
- FWCI
- 26.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications. https://app.cochat.ai/papers/10.1056/nejm198805193182007
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- Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988). Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications. New England Journal of Medicine. https://doi.org/10.1056/nejm198805193182007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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