Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

Flier, Jeffrey S., Underhill, Lisa H., Brownlee, Michael, Cerami, Anthony, Vlassara, Helen·1988·New England Journal of Medicine

DOI 10.1056/nejm198805193182007

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Abstract

IN this seminar we review recent studies suggesting that the central pathologic features of diabetic complications are caused by the hyperglycemia-accelerated formation of nonenzymatic advanced glycosylation end products in tissue. We will emphasize new research findings with important clinical implications, since older information is available in previously published reviews.1 , 2 Other biochemical mechanisms by which hyperglycemia may contribute to the development of diabetic complications are not discussed here, since they are comprehensively reviewed elsewhere.3 4 5 6 7 8 Differences between Early and Advanced Glycosylation ProductsThe central pathophysiologic features of diabetic vascular complications are an abnormal leakage of proteins from the circulation and a progressive . . .

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Untitled work
Laffel (1999) · doi:10.1002/(sici)1520-7560(199911/12)15:6<412::aid-dmrr72>3.0.co;2-8

Authors: Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1988-05-19
Volume: 318
Issue: 20
Pages: 1315-1321
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198805193182007
OpenAlex: W1998614770
Cited by: 2,511
References: 0
FWCI: 26.97
Type: journal article
Language: en
Open access: closed

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Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

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