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The Role of the Vitamin D Endocrine System in Health and Disease
Abstract
The secosteroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the major biologically active metabolite of vitamin D3. (Secosteroids are those in which one of the rings has undergone fission; in vitamin D, this is ring B.) 1,25(OH)2D3 is recognized as the principal mediator within the sphere of action of vitamin D in the regulation of bone and mineral metabolism in humans.1 2 3 Recent evidence has suggested a wider biologic role of 1,25(OH)2D3 in tissues not primarily related to mineral metabolism.Vitamin D MetabolismMetabolic ActivationAn overview of vitamin D . . .
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Citations
Cited by
Pfeifer, M., Begerow, B., & Minne, H. W. (2002) · Osteoporosis International · doi:10.1007/s001980200012 · Cited by 521
Wang, L., Manson, J. E., Buring, J. E., Lee, I.-M., & Sesso, H. D. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.107821 · Cited by 359
Ooms, M. E., Lips, P., Roos, J. C., van der Vijgh, W. J. F., Popp-Snijders, C., Bezemer, P. D., & Bouter, L. M. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100806 · Cited by 286
Vitamin D: A Review on Its Effects on Muscle Strength, the Risk of Fall, and Frailty
Halfon, M., Phan, O., & Teta, D. (2015) · BioMed Research International · doi:10.1155/2015/953241 · Cited by 261
Wang, D. S., Miura, M., Demura, H., & Sato, K. (1997) · Endocrinology · doi:10.1210/endo.138.7.5275 · Cited by 254
Metadata
- Authors
- Reichel, H., Koeffler, H. P., & Norman, A. W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1989-04-13
- Volume
- 320
- Issue
- 15
- Pages
- 980-991
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1965551846
- Cited by
- 1,029
- References
- 0
- FWCI
- 47.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reichel, H., Koeffler, H. P., & Norman, A. W. (1989). The Role of the Vitamin D Endocrine System in Health and Disease. New England Journal of Medicine. https://doi.org/10.1056/nejm198904133201506
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
