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Cited by 1,326Growth Hormone and Insulin-like Growth FactorsHormonal and reproductive studiesPituitary Gland Disorders and Treatments

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

The Effects of Treatment with Recombinant Human Growth Hormone on Body Composition and Metabolism in Adults with Growth Hormone Deficiency

Salomon, Franco, Cuneo, Ross C., Hesp, Richard, Sönksen, Peter H.·1989·New England Journal of Medicine
DOI 10.1056/nejm198912283212605
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Abstract

In a double-blind, placebo-controlled trial, we studied the effects of six months of growth hormone replacement in 24 adults with growth hormone deficiency. Most of the patients had acquired growth hormone deficiency during adulthood as a consequence of treatment for pituitary tumors, and all were receiving appropriate thyroid, adrenal, and gonadal hormone replacement. The daily dose of recombinant human growth hormone (rhGH) was 0.07 U per kilogram of body weight, given subcutaneously at bedtime. The mean (+/- SE) plasma concentration of insulin-like growth factor I increased from 0.41 +/- 0.05 to 1.53 +/- 0.16 U per liter during rhGH treatment. Treatment with rhGH had no effect on body weight. The mean lean body mass, however, increased by 5.5 +/- 1.1 kg (P less than 0.0001), and the fat mass decreased by 5.7 +/- 0.9 kg (P less than 0.0001) in the group treated with growth hormone; neither changed significantly in the placebo group. The basal metabolic rate, measured at base line and after one and six months of rhGH administration, increased significantly; the respective values were 32.4 +/- 1.4, 37.2 +/- 2.2, and 34.4 +/- 1.6 kcal per kilogram of lean body mass per day (P less than 0.001 for both comparisons). Fasting plasma cholesterol levels were lower (P less than 0.05) in the rhGH-treated group than in the placebo group, whereas plasma triglyceride values were similar in the two groups throughout the study. We conclude that growth hormone has a role in the regulation of body composition in adults, probably through its anabolic and lipolytic actions.

Overview

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Crossref · 10.1056/nejm198912283212605

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Citations

Cites

Research works printed but not linked: 2

  1. Manson, 1986, Surgery, 100, 188
  2. Sönksen PH. Double antibody technique for the simultaneous assay of insulin and growth hormone. In: Antoniades HN, ed. Hormones in human blood: detection and assay. Cambridge, Mass.: Harvard University Press, 1976:176–99.

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Metadata

Authors
Salomon, F., Cuneo, R. C., Hesp, R., & Sönksen, P. H.
Affiliations
St Thomas' Hospital (GB)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1989-12-28
Volume
321
Issue
26
Pages
1797-1803
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198912283212605
OpenAlex
W2331609610
Cited by
1,326
References
33
Citations by year
2026: 8 · 2025: 3 · 2024: 10 · 2023: 14 · 2022: 11 · 2021: 14 · 2020: 15 · 2019: 15 · 2018: 16 · 2017: 10 · 2016: 23 · 2015: 21 · 2014: 23 · 2013: 24 · 2012: 28
FWCI
23.23
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
recombinant human growth hormone, growth hormone deficiency, body composition, lean body mass, fat mass, basal metabolic rate, insulin-like growth factor I, pituitary tumors, triglycerides, lipolysis, anabolism, adults
MeSH terms
Adult, Basal Metabolism, Body Composition, Clinical Trials as Topic, Double-Blind Method, Energy Metabolism, Female, Glucose, Humans, Male, Middle Aged, Proteins, Recombinant Proteins, Growth Hormone, Lipid Metabolism

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