The DOI matches its Crossref record, with a small difference in title or year; 26 of the 27 references it cites were found in a registry or an index.
High Blood Alcohol Levels in Women: The Role of Decreased Gastric Alcohol Dehydrogenase Activity and First-Pass Metabolism
Open accessAbstract
After consuming comparable amounts of ethanol, women have higher blood ethanol concentrations than men, even with allowance for differences in size, and are more susceptible to alcoholic liver disease. Recently, we documented significant "first-pass metabolism" of ethanol due to its oxidation by gastric tissue. We report a study of the possible contribution of this metabolism to the sex-related difference in blood alcohol concentrations in 20 men and 23 women. Six in each group were alcoholics. The first-pass metabolism was determined on the basis of the difference in areas under the curves of blood alcohol concentrations after intravenous and oral administration of ethanol (0.3 g per kilogram of body weight). Alcohol dehydrogenase activity was also measured in endoscopic gastric biopsies. In nonalcoholic subjects, the first-pass metabolism and gastric alcohol dehydrogenase activity of the women were 23 and 59 percent, respectively, of those in the men, and there was a significant correlation (rs = 0.659) between first-pass metabolism and gastric mucosal alcohol dehydrogenase activity. In the alcoholic men, the first-pass metabolism and gastric alcohol dehydrogenase activity were about half those in the nonalcoholic men; in the alcoholic women, the gastric mucosal alcohol dehydrogenase activity was even lower than in the alcoholic men, and first-pass metabolism was virtually abolished. We conclude that the increased bioavailability of ethanol resulting from decreased gastric oxidation of ethanol may contribute to the enhanced vulnerability of women to acute and chronic complications of alcoholism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Women and men metabolise alcohol differently because of differences in body fat distribution, body size, and alcohol solubility.7”
From The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis (2017) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Sex-related differences among 100 patients with alcoholic liver disease.
Morgan, M. Y., & Sherlock, S. (1977) · BMJ · doi:10.1136/bmj.1.6066.939 · Cited by 237
Ethanol Elimination in Males and Females: Relationship to Menstrual Cycle and Body Composition
Marshall, A. W., Kingstone, D., Boss, M., & Morgan, M. Y. (1983) · Hepatology · doi:10.1002/hep.1840030513 · Cited by 219
Effects of Fasting and Chronic Alcohol Consumption on the First-Pass Metabolism of Ethanol
DiPadova, C., Worner, T. M., Julkunen, R. J. K., & Lieber, C. S. (1987) · Gastroenterology · doi:10.1016/s0016-5085(87)91073-0 · Cited by 218
Self-citationDistribution of ethanol in the human gastrointestinal tract
Halsted, C. H., Robles, E. A., & Mezey, E. (1973) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/26.8.831 · Cited by 211
Morbidity in alcoholics. Evidence for accelerated development of physical disease in women
Ashley, M. J. (1977) · Archives of Internal Medicine · doi:10.1001/archinte.137.7.883 · Cited by 206
Julkunen, R. J. K., Padova, C. D., & Lieber, C. S. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90470-9 · Cited by 197
Self-citationDo women develop alcoholic liver disease more readily than men?
Saunders, J. B., Davis, M. R., & Williams, R. L. (1981) · BMJ · doi:10.1136/bmj.282.6270.1140 · Cited by 189
Characterization of three isoenzymes of rat alcohol dehydrogenase
Julià, P., Farrés, J., & Parés, X. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb10559.x · Cited by 188
Effects of Cimetidine on Gastric Alcohol Dehydrogenase Activity and Blood Ethanol Levels
Caballería, J., Baraona, E., Rodamilans, M., & Lieber, C. S. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)91562-x · Cited by 174
Self-citation
Research works printed but not linked: 6
- Lamboeuf, 1983, Arch Int Pharmacodyn Ther, 261, 157
- Lin, 1980, Adv Exp Med Biol, 132, 281
- Jones, 1976, Alcohol Tech Rep, 5, 11
- Dixon M, Webb EC. Enzymes. 3rd ed. New York: Academic Press, 1979.
- Leatherbarrow RJ. Enzfitter: a non-linear regression data analysis program for the IBM PC. Amsterdam: Elsevier, 1987.
- Snedecor GW, Cochran WG. Statistical methods. 7th ed. Ames, Iowa: Iowa State University Press, 1980.
Cited by
Sorted by citations
Items 101–200 of 1,000
Smoking, Alcohol, and Neuromuscular and Physical Function of Older Women
Nelson, H. D. (1994) · JAMA · doi:10.1001/jama.1994.03520230035035 · Cited by 188
Ethanol metabolism and its effects on the intestinal epithelial barrier
Elamin, E. E., Masclee, A., Dekker, J. P., & Jonkers, D. M. A. E. (2013) · Nutrition Reviews · doi:10.1111/nure.12027 · Cited by 188
Women and Alcohol Use Disorders
Greenfield, S. F. (2002) · Harvard Review of Psychiatry · doi:10.1080/10673220216212 · Cited by 185
Faster absorption of ethanol and higher peak concentration in women after gastric bypass surgery
Klockhoff, H., Näslund, I., & Jones, A. W. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01698.x · Cited by 183
Gender Similarities and Differences
Zilberman, M. L., Tavares, H., & el‐Guebaly, N. (2003) · Journal of Addictive Diseases · doi:10.1300/j069v22n04_06 · Cited by 183
Brůha, R. (2012) · World Journal of Hepatology · doi:10.4254/wjh.v4.i3.81 · Cited by 181
Prospective Study of Depression and the Risk of Heavy Alcohol Use in Women
Dixit, A. R., & Crum, R. M. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.751 · Cited by 181
Medical risks for women who drink alcohol
Bradley, K. A., Badrinath, S., Bush, K., Boyd-Wickizer, J., & Anawalt, B. D. (1998) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1998.cr187.x · Cited by 185
Emergence of sex differences in the development of substance use and abuse during adolescence
Kuhn, C. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.003 · Cited by 192
Hosseini, N., Shor, J., & Szabó, G. (2019) · Alcohol and Alcoholism · doi:10.1093/alcalc/agz036 · Cited by 179
The Biochemistry of Drug Metabolism – An Introduction
Testa, B., & Krämer, S. D. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790032 · Cited by 180
Nielsen, B. S., Timshel, S., Kjeldsen, L., Sehested, M., Pyke, C., Borregaard, N., & Danø, K. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960103)65:1 · Cited by 173
Fetal Alcohol Syndrome: Current Status of Pathogenesis
Schenker, S., Becker, H. C., Randall, C. L., Phillips, D. K., Baskin, G. S., & Henderson, G. I. (1990) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1990.tb01220.x · Cited by 174
Blood ethanol concentration profiles: a comparison between rats and mice
Livy, D. J., Parnell, S. E., & West, J. R. (2003) · Alcohol · doi:10.1016/s0741-8329(03)00025-9 · Cited by 173
Decreased Corpus Callosum Size Among Alcoholic Women
Hommer, D. W., Momenan, R., Rawlings, R. R., Ragan, P. W., Williams, W., Rio, D., & Eckardt, M. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550040099019 · Cited by 172
White, A. M., Jamieson-Drake, D. W., & Swartzwelder, H. S. (2002) · Journal of American College Health · doi:10.1080/07448480209596339 · Cited by 171
Long-term potentiation in rat hippocampus is inhibited by low concentrations of ethanol
Blitzer, R. D., Gil, O. D., & Landau, E. M. (1990) · Brain Research · doi:10.1016/0006-8993(90)90359-j · Cited by 173
Mechanism of ethanol induced hepatic injury
Lieber, C. S. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90032-w · Cited by 168
Self-citationLet’s talk about sex: Differences in drug therapy in males and females
Madla, C. M., Gavins, F. K. H., Merchant, H. A., Orlu, M., Murdan, S., & Basit, A. W. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.014 · Cited by 167
Lancaster, F. E., Brown, T. D., Coker, K. L., Elliott, J. A., & Wren, S. B. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01945.x · Cited by 164
MEDICAL CONSEQUENCES OF SUBSTANCE ABUSE
Stein, M. D. (1999) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70081-2 · Cited by 163
An application of the Theory of Planned Behavior to sorority alcohol consumption
Huchting, K., Lac, A., & LaBrie, J. W. (2007) · Addictive Behaviors · doi:10.1016/j.addbeh.2007.11.002 · Cited by 162
Alcohol’s Impact on the Cardiovascular System
Roerecke, M. (2021) · Nutrients · doi:10.3390/nu13103419 · Cited by 170
Defining maximum levels of higher alcohols in alcoholic beverages and surrogate alcohol products
Lachenmeier, D. W., Haupt, S., & Schulz, K. (2008) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2007.12.008 · Cited by 157
Lieber, C. S. (2003) · Hepatology Research · doi:10.1016/j.hepres.2003.08.001 · Cited by 156
Self-citationNutrition and human health from a sex–gender perspective
Marino, M., Masella, R., Bulzomi, P., Campesi, I., Malorni, W., & Franconi, F. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.02.001 · Cited by 159
Alcoholic Hepatitis: Current Challenges and Future Directions
Singal, A. K., Kamath, P. S., Gores, G. J., & Shah, V. H. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.06.013 · Cited by 153
Bergmann, M. M., Rehm, J. T., Klipstein‐Grobusch, K., Boeing, H., Schütze, M., Drogan, D., Overvad, K., Tjønneland, A. M., Halkjær, J., Fagherazzi, G., et al. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dyt154 · Cited by 154
Alcohol Consumption, Weight Gain, and Risk of Becoming Overweight in Middle-aged and Older Women
Wang, L. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.527 · Cited by 150
Ethanol Consumption by C57BL/6 Mice
Middaugh, L. D., Kelley, B. M., Bandy, A. E., & McGroarty, K. K. (1999) · Alcohol · doi:10.1016/s0741-8329(98)00055-x · Cited by 152
Genetic determinants of alcoholic liver disease
Stickel, F., & Hampe, J. (2011) · Gut · doi:10.1136/gutjnl-2011-301239 · Cited by 150
Alcohol impairment of behavior in men and women
Fillmore, M. T., & Weafer, J. J. (2004) · Addiction · doi:10.1111/j.1360-0443.2004.00805.x · Cited by 157
Backer, G. D., Ambrosio, G., Borch‐Johnsen, K., Brotons, C., Cífková, R., Dallongeville, J., Ebrahim, S. B. J., Færgeman, O., Graham, I. D., Mancia, G., et al. (2003) · PubMed · doi:10.1097/01.hjr.0000087913.96265.e2 · Cited by 153
Standardization of alcohol calculations in research.
Brick, J. (2006) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00155.x · Cited by 143
Hashimoto, Y., Hamaguchi, M., Kojima, T., Ohshima, Y., Ohbora, A., Kato, T., Nakamura, N., & Fukui, M. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12786 · Cited by 146
Hernández-Muñoz, R. E., Caballería, J., Baraona, E., Uppal, R., Greenstein, R. J., & Lieber, C. S. (1990) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1990.tb01843.x · Cited by 146
Self-citationRIVIER, C. L. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00853.x · Cited by 145
Rodent models of alcoholic liver disease: Of mice and men
Brandon‐Warner, E., Schrum, L. W., Schmidt, C. M., & McKillop, I. H. (2012) · Alcohol · doi:10.1016/j.alcohol.2012.08.004 · Cited by 144
Rodent Models of Alcoholic Liver Disease: Role of Binge Ethanol Administration
Dastidar, S. G., Warner, J. B., Warner, D. R., McClain, C. J., & Kirpich, I. (2018) · Biomolecules · doi:10.3390/biom8010003 · Cited by 142
Ikehara, S., Iso, H., Toyoshima, H., Date, C., Yamamoto, A., Kikuchi, S., Kondo, T., Watanabe, Y., Koizumi, A., Wada, Y., et al. (2008) · Stroke · doi:10.1161/strokeaha.108.520288 · Cited by 141
Alcohol, liver, and nutrition.
Lieber, C. S. (1991) · Journal of the American College of Nutrition · doi:10.1080/07315724.1991.10718182 · Cited by 141
Self-citationDrobes, D. J., Anton, R. F., Thomas, S. E., & Voronin, K. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000139704.88862.01 · Cited by 140
Brumback, T., Cao, D., & King, A. C. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.04.013 · Cited by 140
Sex Difference in Alcohol‐Related Organ Injury
Sato, N., Lindros, K. O., Baraona, E., Ikejima, K., Mezey, E., Järveläinen, H. A., & Ramchandani, V. A. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02371.x · Cited by 139
Self-citationEffects of alcohol on skeletal and cardiac muscle
Urbano-Márquez, A., & Fernández‐Solà, J. (2004) · Muscle & Nerve · doi:10.1002/mus.20168 · Cited by 139
Schernhammer, E. S., Bertrand, K. A., Birmann, B. M., Sampson, L., Willett, W. C., & Feskanich, D. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.030833 · Cited by 137
Maternal Periconceptional Alcohol Consumption and Risk of Orofacial Clefts
Romitti, P. A., Sun, L., Honein, M. A., Reefhuis, J., Correa, A., Rasmussen, S. A., & Study, T. N. B. D. P. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm146 · Cited by 137
Pharmacokinetic Strategies in Deciphering Atypical Drug Absorption Profiles
Zhou, H. (2003) · The Journal of Clinical Pharmacology · doi:10.1177/0091270002250613 · Cited by 140
Prevalence and Natural History of Alcoholic Liver Disease
Schwartz, J. M., & Reinus, J. F. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.08.001 · Cited by 136
Yin, S., Chou, F., Chao, S., Tsai, S., Liao, C., Wang, S.-L., Wu, C.-W., & Lee, S. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00779.x · Cited by 136
First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying
Oneta, C. M., Simanowski, U. A., Martı́nez, M. C., Allali‐Hassani, A., Parés, X., Homann, N., Conradt, C., Waldherr, R., Fiehn, W., Coutelle, C., et al. (1998) · Gut · doi:10.1136/gut.43.5.612 · Cited by 136
Aspirin Increases Blood Alcohol Concentrations in Humans After Ingestion of Ethanol
Roine, R. P. (1990) · JAMA · doi:10.1001/jama.1990.03450180070031 · Cited by 136
Alcohol consumption and body weight
French, M. T., Norton, E. C., Fang, H., & Maclean, J. C. (2009) · Health Economics · doi:10.1002/hec.1521 · Cited by 133
Sieri, S., Agudo, A., Kesse‐Guyot, E., Klipstein‐Grobusch, K., SanJosé, B., Welch, A., Krogh, V., Luben, R., Allen, N. E., Overvad, K., et al. (2002) · Public Health Nutrition · doi:10.1079/phn2002405 · Cited by 135
King, A. C., Hasin, D., O’Connor, S. J., McNamara, P. J., & Cao, D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.007 · Cited by 132
Sex and gender influences on pharmacological response: an overview
Franconi, F., & Campesi, I. (2014) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2014.922866 · Cited by 139
Gender differences in human pharmacokinetics and pharmacodynamics
Fletcher, C. V., Acosta, E. P., & Strykowski, J. M. (1994) · Journal of Adolescent Health · doi:10.1016/s1054-139x(94)90628-9 · Cited by 129
Pharmacokinetic Interactions Between Alcohol and Other Drugs
Fraser, A. G. (1997) · Clinical Pharmacokinetics · doi:10.2165/00003088-199733020-00001 · Cited by 128
Lee, S. D., Chau, G., Yao, C., Wu, C.-W., & Yin, S. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00139.x · Cited by 127
Forensic urinalysis of drug use in cases of alleged sexual assault
Hindmarch, I., ElSohly, M. A., Gambles, J., & Salamone, S. J. (2001) · Journal of Clinical Forensic Medicine · doi:10.1054/jcfm.2001.0513 · Cited by 127
Gender as a Risk Factor for Adverse Events to Medications
Kando, J. C., Yonkers, K. A., & Cole, J. O. (1995) · Drugs · doi:10.2165/00003495-199550010-00001 · Cited by 126
Pascual, M., Montesinos, J., Marcos, M., Torres, J. L., Costa‐Alba, P., Garcia‐García, F., Laso, F. J., & Guerri, C. (2016) · Addiction Biology · doi:10.1111/adb.12461 · Cited by 128
Sex Differences in Alcohol Consumption and Alcohol-Associated Liver Disease
Kezer, C. A., Simonetto, D. A., & Shah, V. H. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.08.020 · Cited by 125
Relation of alcohol intake to left ventricular mass: The Framingham study
Manolio, T. A., Levy, D. A., Garrison, R. J., Castelli, W. P., & Kannel, W. B. (1991) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(10)80189-5 · Cited by 125
Ammon, E., Schäfer, C., Hofmann, U., & Klotz, U. E. (1996) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(96)90178-2 · Cited by 125
A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme.
Yasunami, M., Chen, C. S., & Yoshida, A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7610 · Cited by 124
Fillmore, M. T., & Jude, R. (2011) · American Journal on Addictions · doi:10.1111/j.1521-0391.2011.00156.x · Cited by 123
Lowe, P., Gyöngyösi, B., Satishchandran, A., Iracheta‐Vellve, A., Cho, Y., Ambade, A., & Szabó, G. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1328-9 · Cited by 126
Arab, J. P., Roblero, J. P., Altamirano, J., Bessone, F., Araújo, R. C., la Tijera, F. H., Restrepo, J. C., Torre, A., Urzua, A. M., Simonetto, D. A., et al. (2019) · Annals of Hepatology · doi:10.1016/j.aohep.2019.04.005 · Cited by 126
Fukuda, Y., Hashimoto, Y., Hamaguchi, M., Fukuda, T., Nakamura, N., Ohbora, A., Kato, T., Kojima, T., & Fukui, M. (2015) · Liver International · doi:10.1111/liv.12977 · Cited by 114
Outcomes in liver transplantation: Does sex matter?
Sarkar, M. A., Watt, K. D. S., Terrault, N. A., & Berenguer, M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.11.023 · Cited by 116
Issues in the definition and measurement of drinking outcomes in alcoholism treatment research.
Babor, T. F., Longabaugh, R., Zweben, A., Fuller, R. K., Stout, R. L., Anton, R. F., & Randall, C. L. (1994) · Journal of Studies on Alcohol Supplement · doi:10.15288/jsas.1994.s12.101 · Cited by 116
Alcohol Use Disorders in Primary Care. Do Gender-specific Differences Exist?
Brienza, R. S., & Stein, M. D. (2002) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2002.10617.x · Cited by 117
van Soest, A., Delaney, L. D., Harmon, C. P., Kapteyn, A., & Smith, J. P. (2011) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.1111/j.1467-985x.2011.00694.x · Cited by 114
First‐Pass Metabolism of Ethanol Is Predominantly Gastric
Lim, R. T., Gentry, R. T., Ito, D., Yokoyama, H., Baraona, E., & Lieber, C. S. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb05250.x · Cited by 113
Self-citationAlcoholism in women: is it different in onset and outcome compared to men?
Diehl, A., Croissant, B., Batra, A., Mundle, G., Nakovics, H., & Mann, K. F. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0737-z · Cited by 112
Lieber, C. S. (1992) · Springer eBooks · doi:10.1007/978-1-4615-3320-7_1 · Cited by 112
Self-citationPoelen, E. A. P., Scholte, R. H. J., Engels, R. C. M. E., Boomsma, D. I., & Willemsen, G. A. H. M. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.03.020 · Cited by 111
Gender Differences in Alcohol Treatment: An Analysis of Outcome From the COMBINE Study
Greenfield, S. F., Pettinati, H. M., O’Malley, S. S., Randall, P. K., & Randall, C. L. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01267.x · Cited by 110
Influence of alcohol and gender on immune response.
Kovacs, E. J., & Messingham, K. N. (2002) · Europe PMC (PubMed Central) · Cited by 110
Sex Differences in Alcohol Drinking Patterns During Forced and Voluntary Consumption in Rats
Juárez, J., & Tomasi, E. B. D. (1999) · Alcohol · doi:10.1016/s0741-8329(99)00010-5 · Cited by 110
Pharmacokinetic and Pharmacodynamic Drug Interactions with Ethanol (Alcohol)
Chan, L., & Anderson, G. D. (2014) · Clinical Pharmacokinetics · doi:10.1007/s40262-014-0190-x · Cited by 109
Alcohol consumption and risk of heart failure: the Atherosclerosis Risk in Communities Study
Gonçalves, A., Claggett, B. L., Jhund, P. S., Rosamond, W. D., Deswal, A. M., Aguilar, D. A., Shah, A. M., Cheng, S. C., & Solomon, S. D. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu514 · Cited by 120
Effects of Alcoholism and Gender on Brain Metabolism
Schweinsburg, B. C., Alhassoon, O. M., Taylor, M. J., González, R., Videen, J. S., Brown, G. G., Patterson, T. L., & Grant, I. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1180 · Cited by 108
Göransson, M., Magnusson, Å., Bergman, H., Rydberg, U. S., & Heilig, M. A. (2003) · Addiction · doi:10.1046/j.1360-0443.2003.00498.x · Cited by 106
Quinn, D. I., Wodak, A., & Day, R. O. (1997) · Clinical Pharmacokinetics · doi:10.2165/00003088-199733050-00003 · Cited by 106
Lex, B. W. (1994) · Humana Press eBooks · doi:10.1007/978-1-4612-0299-8_12 · Cited by 106
Effect of Concentration of Ingested Ethanol on Blood Alcohol Levels
Roine, R. P., Gentry, R. T., Lim, R. T., Baraona, E., & Lieber, C. S. (1991) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1991.tb00589.x · Cited by 102
Self-citationBalodis, I. M., Potenza, M. N., & Olmstead, M. C. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328330c779 · Cited by 101
Effects of alcohol on brain responses to social signals of threat in humans
Sripada, C. S., Angstadt, M., McNamara, P., King, A. C., & Phan, K. L. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.062 · Cited by 101
Lieber, C. S., & DeCarli, L. M. (1991) · Journal of Hepatology · doi:10.1016/0168-8278(91)90846-4 · Cited by 101
Self-citationMeasuring effectiveness. What to expect without a randomized control group.
D’Agostino, R. B., & Russell, H. K. (1995) · PubMed · Cited by 100
Gender, Styles of Deviance, and Drinking Problems
Robbins, C. A., & Martin, S. S. (1993) · Journal of Health and Social Behavior · doi:10.2307/2137369 · Cited by 99
Baraona, E., & Lieber, C. S. (1998) · Springer eBooks · doi:10.1007/0-306-47148-5_5 · Cited by 101
Self-citationCigarette smoking and rate of gastric emptying: effect on alcohol absorption.
Johnson, R. D., Horowitz, M., Maddox, A. F., Wishart, J. M., & Shearman, D. J. C. (1991) · BMJ · doi:10.1136/bmj.302.6767.20 · Cited by 98
Banerjee, A. M., Apte, U., Smith, R., & Ramaiah, S. (2006) · The Journal of Pathology · doi:10.1002/path.1917 · Cited by 97
CARBOHYDRATE-DEFICIENT TRANSFERRIN (CDT)—A BIOMARKER FOR LONG-TERM ALCOHOL CONSUMPTION
Golka, K., & Wiese, A. (2004) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937400490432400 · Cited by 97
Trends in Hepatocellular Carcinoma Mortality Rates in the US and Projections Through 2040
Qiu, S., Cai, J., Yang, Z., He, X., Xing, Z., Zu, J., Xie, E., Henry, L. L., Chong, C. R., John, E. M., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.45525 · Cited by 104
Epidemiology of Risk Factors for Hypertension
Kornitzer, M., Dramaix, M., & Backer, G. D. (1999) · Drugs · doi:10.2165/00003495-199957050-00003 · Cited by 99
Levitt, M. D., Li, R., DeMaster, E. G., Elson, M. K., Furne, J. K., & Levitt, D. G. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.4.g951 · Cited by 96
Metadata
- Authors
- Frezza, M., di Padova, C., Pozzato, G., Terpin, M., Baraona, E., & Lieber, C. S.
- Affiliations
- University of Trieste (IT)
- Mount Sinai Hospital (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1990-01-11
- Volume
- 322
- Issue
- 2
- Pages
- 95-99
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2955761657
- Cited by
- 1,328
- References
- 27
- Citations by year
- 2026: 34 · 2025: 42 · 2024: 27 · 2023: 26 · 2022: 42 · 2021: 40 · 2020: 36 · 2019: 50 · 2018: 27 · 2017: 30 · 2016: 34 · 2015: 34 · 2014: 35 · 2013: 30 · 2012: 36
- FWCI
- 66.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p50aa003508-18)
- National Institute on Alcohol Abuse and Alcoholism (AA-03508)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- sex differences, blood alcohol concentration, alcohol metabolism, first-pass metabolism, gastric alcohol dehydrogenase, alcoholism, alcoholic liver disease
- MeSH terms
- Adult, Alcohol Oxidoreductases, Ethanol, Alcoholism, Biological Availability, Female, Gastric Mucosa, Humans, Male, Metabolic Clearance Rate, Middle Aged, Oxidation-Reduction, Sex Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
