The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Decreased Erythropoietin Response in Patients with the Anemia of Cancer
Open accessAbstract
Patients with solid tumors are often anemic even before they undergo cytotoxic therapy. Since the cause of the anemia of cancer is unknown, we examined the possible role of erythropoietin. Using a sensitive radioimmunoassay, we determined serum immunoreactive erythropoietin levels in 81 anemic patients with solid tumors. For any given degree of anemia, the serum concentration of immunoreactive erythropoietin was lower in this group of patients than in a group of control patients with iron-deficiency anemia (P = 0.0001). Furthermore, the expected inverse linear relation between serum levels of immunoreactive erythropoietin and of hemoglobin was absent in the group with cancer. The erythropoietin response was further decreased in patients receiving chemotherapy; it was not influenced by the presence or absence of cisplatin in the treatment regimen. The inability of the patients with cancer to produce erythropoietin was not absolute; if they had hypoxemia, adequate erythropoietin production was restored. We conclude that erythropoietin levels are inappropriately low in anemia associated with cancer, and that erythropoietin deficiency may contribute to the development of this form of anemia. Treatment of the anemia of cancer with erythropoietin may be of value.
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Cites
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Weiss, G., & Goodnough, L. T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041809 · Cited by 3,800
Ganz, T. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1804281 · Cited by 589
Effect of inflammatory cytokines on hypoxia-induced erythropoietin production
Faquin, W., Schneider, T., & Goldberg, M. (1992) · Blood · doi:10.1182/blood.v79.8.1987.1987 · Cited by 532
Vansteenkiste, J. (2002) · CancerSpectrum Knowledge Environment · doi:10.1093/jnci/94.16.1211 · Cited by 477
Crawford, J., Cella, D., Cleeland, C. S., Cremieux, P., Demetri, G. D., Sarokhan, B. J., Slavin, M. B., & Glaspy, J. A. (2002) · Cancer · doi:10.1002/cncr.10763 · Cited by 428
Metadata
- Authors
- Miller, C. B., Jones, R. J., Piantadosi, S., Abeloff, M. D., & Spivak, J. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1990-06-14
- Volume
- 322
- Issue
- 24
- Pages
- 1689-1692
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2340124568
- Cited by
- 658
- References
- 14
- FWCI
- 21.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Miller, C. B., Jones, R. J., Piantadosi, S., Abeloff, M. D., & Spivak, J. L. (1990). Decreased Erythropoietin Response in Patients with the Anemia of Cancer. New England Journal of Medicine. https://doi.org/10.1056/nejm199006143222401
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
