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Therapeutic Uses of Botulinum Toxin
Abstract
BOTULISM had been recognized by the 18th century, but the observation that a toxin produced by an anaerobic organism might be responsible for food poisoning was not made until 1897.1 Although seven immunologically distinct toxins have since been identified, only types A, B, and E have been linked to cases of botulism in humans.2 , 3 Botulinum toxin type A (hereafter referred to as botulinum toxin), one of the most lethal biologic toxins, has been found to be of therapeutic value in the treatment of a variety of neurologic and ophthalmologic disorders.4 The Food and Drug Administration recently approved botulinum toxin (Oculinum) . . .
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Cites
Essential tremor: Clinical correlates in 350 patients
Lou, J.-S., & Jankovic, J. (1991) · Neurology · doi:10.1212/wnl.41.2_part_1.234 · Cited by 375
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Leader, B., Baca, Q. J., & Golan, D. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2399 · Cited by 2,161
Tourette syndrome, associated conditions and the complexities of treatment
Robertson, M. M. (2000) · Brain · doi:10.1093/brain/123.3.425 · Cited by 704
Jankovic, J., Schwartz, K., Clemence, W., Aswad, A., & Mordaunt, J. (1996) · Movement Disorders · doi:10.1002/mds.870110306 · Cited by 235
Self-citationGuarda-Nardini, L., Stecco, A., Stecco, C., Masiero, S., & Manfredini, D. (2012) · CRANIO® · doi:10.1179/crn.2012.014 · Cited by 159
Metadata
- Authors
- Oates, J. A., Wood, A. J. J., Jankovic, J., & Brin, M. F.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1991-04-25
- Volume
- 324
- Issue
- 17
- Pages
- 1186-1194
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2050344640
- Cited by
- 801
- References
- 1
- FWCI
- 22.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Oates, J. A., Wood, A. J. J., Jankovic, J., & Brin, M. F. (1991). Therapeutic Uses of Botulinum Toxin. New England Journal of Medicine. https://doi.org/10.1056/nejm199104253241707
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.