The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Recombinant Granulocyte-Macrophage Colony-Stimulating Factor after Autologous Bone Marrow Transplantation for Lymphoid Cancer
Open accessAbstract
BACKGROUND: The period of neutropenia after autologous bone marrow transplantation results in substantial morbidity and mortality. The results of previous phase I-II clinical trials suggest that recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) may accelerate neutrophil recovery and thereby reduce complications in patients after autologous bone marrow transplantation. METHODS: We conducted a randomized, double-blind, placebo-controlled trial at three institutions. The study design and treatment schedules were identical, and the results were pooled for analysis. One hundred twenty-eight patients were enrolled. Sixty-five patients received rhGM-CSF in a two-hour intravenous infusion daily for 21 days, starting within four hours of the marrow infusion, and 63 patients received placebo. RESULTS: No toxic effects specifically ascribed to rhGM-CSF were observed. The patients given rhGM-CSF had a recovery of the neutrophil count to 500 x 10(6) per liter 7 days earlier than the patients who received placebo (19 vs. 26 days, P less than 0.001), had fewer infections, required 3 fewer days of antibiotic administration (24 vs. 27 days, P = 0.009), and required 6 fewer days of initial hospitalization (median, 27 vs. 33 days; P = 0.01). There was no difference in the survival rate at day 100. CONCLUSIONS: In patients undergoing autologous bone marrow transplantation for lymphoid neoplasia, rhGM-CSF significantly lessens morbidity. Further studies will be required to establish its optimal dosage and schedule of administration.
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The Granulocyte-Macrophage Colony-Stimulating Factors
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Self-citationEconomic Analysis Alongside Clinical Trials: Revisiting the Methodological Issues
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Waselenko, J. K., MacVittie, T. J., Blakely, W. F., Pesik, N., Wiley, A. L., Dickerson, W. E., Tsu, H., Confer, D. L., Coleman, C. N., Seed, T., et al. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-12-200406150-00015 · Cited by 766
Self-citationPathogenesis of Acute Respiratory Distress Syndrome
Huppert, L., Matthay, M., & Ware, L. (2019) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0039-1683996 · Cited by 459
Metadata
- Authors
- Nemunaitis, J., Rabinowe, S. N., Singer, J. W., Bierman, P. J., Vose, J. M., Freedman, A. S., Onetto, N., Gillis, S., Oette, D., Gold, M., Buckner, C. D., Hansen, J. A., Ritz, J., Appelbaum, F. R., Armitage, J. O., & Nadler, L. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1991-06-20
- Volume
- 324
- Issue
- 25
- Pages
- 1773-1778
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2593892363
- Cited by
- 486
- References
- 17
- FWCI
- 44.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Recombinant Granulocyte-Macrophage Colony-Stimulating Factor after Autologous Bone Marrow Transplantation for Lymphoid Cancer. https://app.cochat.ai/papers/10.1056/nejm199106203242504
- The paper
- Nemunaitis, J., Rabinowe, S. N., Singer, J. W., Bierman, P. J., Vose, J. M., Freedman, A. S., Onetto, N., Gillis, S., Oette, D., Gold, M., Buckner, C. D., Hansen, J. A., Ritz, J., Appelbaum, F. R., Armitage, J. O., & Nadler, L. M. (1991). Recombinant Granulocyte-Macrophage Colony-Stimulating Factor after Autologous Bone Marrow Transplantation for Lymphoid Cancer. New England Journal of Medicine. https://doi.org/10.1056/nejm199106203242504
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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