Chest Pain in Cardiac-Transplant Recipients: Evidence of Sensory Reinnervation after Cardiac Transplantation
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ALTHOUGH coronary artery disease develops within three years of heart transplantation in up to 40 percent of transplant recipients,1 , 2 chest pain late after cardiac transplantation is usually dismissed as being noncardiac because it has been assumed that the transplanted heart is permanently denervated. The presumption that the donor heart remains denervated in humans is based primarily on the lack of appropriate neural reflex—mediated changes in the heart rate.3 , 4 That reinnervation would not occur is surprising, because there is extensive evidence of sympathetic reinnervation after cardiac transplantation in nearly all animal models.5 6 7 8 In the transplanted heart, sympathetic nerves are severed from . . .
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Some findings suggest limited sensory fiber re-innervation, as evidenced by pain provoked by cardiac ischemia in heart transplant patients or lobeline injections in lung transplant patients.
“Some findings also suggest limited sensory fiber re-innervation, as evidenced by the fact that pain can be provoked by cardiac ischemia in heart transplant patients [39] or lobeline injections in lung transplant patients [40].”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [39]
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McAllister, S. L., Dmitrieva, N., & Berkley, K. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031758 · Cited by 60 · see citing works
“Some findings also suggest limited sensory fiber re-innervation, as evidenced by the fact that pain can be provoked by cardiac ischemia in heart transplant patients [39] or lobeline injections in lung transplant patients [40].”
Immunohistochemical studies on the innervation of human transplanted liver.
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- Authors
- Stark, R. P., McGinn, A. L., & Wilson, R. F.
- Affiliations
- University of Minnesota (US)
- ORCID
- Wilson, Robert F.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1991-06-20
- Volume
- 324
- Issue
- 25
- Pages
- 1791-1794
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2067329441
- Cited by
- 222
- References
- 19
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 6
- FWCI
- 19.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- chest pain, heart transplantation, coronary artery disease, cardiac denervation
- MeSH terms
- Adult, Aged, Angina Pectoris, Chest Pain, Female, Heart, Humans, Male, Middle Aged, Nerve Regeneration, Norepinephrine, Postoperative Complications, Sympathetic Nervous System, Tyramine, Heart Transplantation
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