The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
β-Amyloid and the Pathogenesis of Alzheimer's Disease
Abstract
SIXTY to 80 percent of cases of dementia among persons over the age of 65 are caused by Alzheimer's disease. Most of the remainder are caused by cerebrovascular disease with multiple infarcts, and a smaller proportion are due to tumors, infections (e.g., infection with the human immunodeficiency virus), metabolic disorders, depression ("pseudodementia"), and the less common neurodegenerative diseases, including Pick's disease, progressive supranuclear palsy, and Huntington's disease.1 2 3 Alzheimer's disease has been estimated to afflict 5 to 11 percent of the population over the age of 65 and as much as 47 percent of the population over the age of 85. . . .
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Citations
Cites
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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
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Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
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Self-citationA68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau
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Cited by
Jarrett, J. T., Berger, E. P., & Lansbury, P. T. (1993) · Biochemistry · doi:10.1021/bi00069a001 · Cited by 2,022
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
Lorenzo, A., & Yankner, B. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.12243 · Cited by 1,324
Self-citationActivation of microglial cells by β-amyloid protein and interferon-γ
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A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain
Wang, J., Gu, B. J., Masters, C. L., & Wang, Y.-J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.111 · Cited by 808
Tau is essential to β-amyloid-induced neurotoxicity
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Metadata
- Authors
- Flier, J. S., Underhill, L. H., Yankner, B. A., & Mesulam, M.-M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1991-12-26
- Volume
- 325
- Issue
- 26
- Pages
- 1849-1857
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2327752912
- Cited by
- 207
- References
- 27
- FWCI
- 15.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: β-Amyloid and the Pathogenesis of Alzheimer's Disease. https://app.cochat.ai/papers/10.1056/nejm199112263252605
- The paper
- Flier, J. S., Underhill, L. H., Yankner, B. A., & Mesulam, M.-M. (1991). β-Amyloid and the Pathogenesis of Alzheimer's Disease. New England Journal of Medicine. https://doi.org/10.1056/nejm199112263252605
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
