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Cited by 4,117Dementia and Cognitive Impairment ResearchAging and Gerontology ResearchNutrition and Health in Aging

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

Blessed, G., Tomlinson, B. E., Roth, Martin·1968·British Journal of Psychiatry
DOI 10.1192/bjp.114.512.797
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Abstract

The ageing of many populations in recent years has directed increasing attention to the social, medical and biological problems of senescence. The psychological changes associated with ageing occupy a central position in inquiries in this field. The expectation of mental disorder shows a steep increase with advancing chronological age, and beyond 75 years a large part of this increase is accounted for by disorders associated with degenerative changes in the central nervous system for which we lack remedies at the present time. Larsson et al . (1963) have estimated that the aggregate morbidity risk for these disorders up to the age of 70 is 0·4 per cent., up to age 75, 1·2 per cent. and up to age 80, 5 per cent. For higher ages estimates were probably less reliable, but the calculated risk up to the age of 90 was 5·2 per cent. In a survey of a random sample of elderly people aged 65 and over in the general population, Kay et al . (1964), found a total of 4·2 per cent. of elderly subjects to be suffering from senile dementia, 2·9 per cent. being mild cases. The condition is generally recognized as being a major cause of serious infirmity among the elderly in psychiatric, geriatric, general medical and community practice alike.

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Crossref · 10.1192/bjp.114.512.797

Cites

22 of 22 references verified0 citation errors · 0 not checkable

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  • Most CPC studies confirm a significant correlation between antemortem cognitive impairment and neocortical AβPs.

    “Although the study designs were diverse in CPC studies involving AβPs, most studies confirm a significant correlation between antemortem cognitive impairment and neocortical AβPs, as demonstrated by Blessed et al (254) (Fig. 3).”

    From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [254]

  • The seminal articles of Blessed et al, Roth et al, and Tomlinson et al found a correlation between dementia severity and amyloid plaques counted in cerebral cortex.

    “Studies not shown in Table 5 include the seminal articles of Blessed et al (254), Roth et al (255), and Tomlinson et al (38, 256), which found a correlation between dementia severity and amyloid plaques counted in cerebral cortex (with the caveat described previously)”

    From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [254]

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Related

Authors
Blessed, G., Tomlinson, B. E., & Roth, M.
Affiliations
Newcastle University (GB)
ORCID
Roth, Martin
Venue
British Journal of Psychiatry
Publisher
Royal College of Psychiatrists
Published
1968-07
Volume
114
Issue
512
Pages
797-811
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
DOI
10.1192/bjp.114.512.797
OpenAlex
W2159529587
Cited by
4,117
References
22
Citations by year
2026: 39 · 2025: 39 · 2024: 48 · 2023: 43 · 2022: 51 · 2021: 71 · 2020: 73 · 2019: 82 · 2018: 63 · 2017: 62 · 2016: 68 · 2015: 77 · 2014: 79 · 2013: 85 · 2012: 105
FWCI
16.74
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 18109 d)
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
dementia, senile dementia, brain aging, older adults, central nervous system degeneration, cognitive decline
MeSH terms
Aged, Aging, Cerebral Cortex, Delirium, Dementia, Depression, Female, Humans, Intelligence, Male, Personality, Psychological Tests

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