The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Cumulative Meta-Analysis of Therapeutic Trials for Myocardial Infarction
Open accessAbstract
BACKGROUND: The large volume of published randomized, controlled trials has led to a need for meta-analyses to track therapeutic advances. Performing a new meta-analysis whenever the results of a new trial of a particular therapy are published permits the study of trends in efficacy and makes it possible to determine when a new treatment appears to be significantly effective or deleterious. We describe the use of such a procedure, cumulative meta-analysis, to assess therapeutic trials among patients with myocardial infarction. METHODS: We performed cumulative meta-analyses of clinical trials that evaluated 15 treatments and preventive measures for acute myocardial infarction. RESULTS: An example of this method is its application to the use of intravenous streptokinase as thrombolytic therapy for acute infarction. Thirty-three trials evaluating this therapy were performed between 1959 and 1988. We found that a consistent, statistically significant reduction in total mortality (odds ratios, 0.74; 95 percent confidence interval, 0.59 to 0.92) was achieved in 1973, after only eight trials involving 2432 patients had been completed. The results of the 25 subsequent trials, which enrolled an additional 34,542 patients through 1988, had little or no effect on the odds ratio establishing efficacy, but simply narrowed the 95 percent confidence interval. In particular, two very large trials, the Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico trial in 1986 (11,712 patients) and the Second International Study of Infarct Survival trial in 1988 (17,187 patients) did not modify the already established evidence of efficacy. We used a similar approach to study the accumulating evidence of efficacy (or lack of efficacy) of 14 other therapies and preventive measures for myocardial infarction. CONCLUSIONS: Cumulative meta-analysis of therapeutic trials facilitates the determination of clinical efficacy and harm and may be helpful in tracking trials, planning future trials, and making clinical recommendations for therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“While several tools have been developed to accelerate SRs 4,5 , none are capable of full automation with human-level accuracy.”
From Automation of Systematic Reviews with Large Language Models (2025) · cites this paper as [5]
Experimental — accuracy not yet measuredIn the citing paper
“Lau and colleagues demonstrated that, had a cumulative meta-analysis been regularly updated, the beneficial effect of streptokinase in patients who had experienced an acute myocardial infarction would have been established by 1973”
From Commentary: Two-sample Mendelian randomization: opportunities and challenges (2016) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
The file drawer problem and tolerance for null results.
Rosenthal, R. (1979) · Psychological Bulletin · doi:10.1037/0033-2909.86.3.638 · Cited by 9,068
Beta blockade during and after myocardial infarction: An overview of the randomized trials
Yusuf, S., Peto, R., Lewis, J., Collins, R., & Sleight, P. (1985) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(85)80003-7 · Cited by 3,205
急性心筋梗塞の疑いのある17187症例におけるストレプトキナーゼ静脈内投与,アスピリン経口投与,上記2つの併用または無処置の無作偽試験 ISIS-2
Dienstl, F., Backer, G. D., Cairns, J., Pedersen, F., Kala, R., Boissel, J., Schroeder, R., Horgan, J., & Tognoni, G. (1988) · The Lancet · Cited by 2,754
An overview of randomized trials of rehabilitation with exercise after myocardial infarction.
O'Connor, G. T., Buring, J. E., Yusuf, S., Goldhaber, S. Z., Olmstead, E. M., Paffenbarger, R. S., & Hennekens, C. H. (1989) · Circulation · doi:10.1161/01.cir.80.2.234 · Cited by 1,414
Collins, R., Scrimgeour, A., Yusuf, S., & Peto, R. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805053181805 · Cited by 1,307
Meta-Analysis in Clinical Research
L'ABBÉ, K. A., DETSKY, A. S., & O'ROURKE, K. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-2-224 · Cited by 1,267
Meta-Analyses of Randomized Controlled Trials
Sacks, H. S., Berrier, J., Reitman, D., Ancona-Berk, V. A., & Chalmers, T. C. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702193160806 · Cited by 1,257
Self-citationSecondary prevention of vascular disease by prolonged antiplatelet treatment
Antiplatelet Trialists' Collaboration (1988) · BMJ · doi:10.1136/bmj.296.6618.320 · Cited by 1,048
Research works printed but not linked: 14
- 10.1001/jama.268.2.240 · DOI · Paper page
- Mantel, 1959, J Natl Cancer Inst, 22, 719
- Lau, Controlled Clin Trials
- 1982, Lancet, 1, 1159
- ISIS-2 (Second International Study of Infarct Survival) Collaborative Group, 1988, Lancet, 2, 349
- 10.1001/archinte.149.12.2694 · DOI
- Lewis, 1982, Prim Cardiol, 31
- Baber, 1983, Circulation, 67, I-71
- Furberg, 1983, Circulation, 67, I-83
- 1980, Lancet, 1, 1172
- Canner, 1983, Isr J Med Sci, 19, 413
- 10.1001/jama.260.7.945 · DOI · Paper page
- Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISST), 1986, Lancet, 1, 397
- The Aspirin Myocardial Infarction Study Research Group, 1980, Circulation, 62, V-79
Cited by
Sorted by citations
Items 101–200 of 1,000
Bauer, T., Bouman, H. J., van Werkum, J. W., Ford, N. F., ten Berg, J. M., & Taubert, D. (2011) · BMJ · doi:10.1136/bmj.d4588 · Cited by 263
Yu, T., Lin, Y., Zhang, Y., Yang, J., Zhang, Y., Liu, H., & Zhang, B. (2009) · BMC Medical Genetics · doi:10.1186/1471-2350-10-15 · Cited by 267
Gilbert, R. E., Salanti, G., Harden, M., & See, S. E. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi088 · Cited by 261
Adjunctive Drug Therapy of Acute Myocardial Infarction — Evidence from Clinical Trials
Hennekens, C. H., Albert, C. M., Godfried, S. L., Gaziano, J. M., & Buring, J. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199611283352207 · Cited by 259
Uses and abuses of meta-analysis
Egger, M., Smith, G. D., & Sterne, J. A. C. (2001) · Clinical Medicine · doi:10.7861/clinmedicine.1-6-478 · Cited by 258
Ottani, F., Galvani, M., Nicolini, F. A., Ferrini, D., Pozzati, A., Pasquale, G. D., & Jaffe, A. S. (2000) · American Heart Journal · doi:10.1067/mhj.2000.111107 · Cited by 253
Aspirin at any dose above 30 mg offers only modest protection after cerebral ischaemia.
Algra, A., & van Gijn, J. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.60.2.197 · Cited by 255
Factors associated with cardiac rehabilitation attendance: a systematic review of the literature
Cooper, A. F., Jackson, G., Weinman, J. A., & Horne, R. (2002) · Clinical Rehabilitation · doi:10.1191/0269215502cr524oa · Cited by 254
Capewell, S., Beaglehole, R., Seddon, M., & McMurray, J. J. V. (2000) · Circulation · doi:10.1161/01.cir.102.13.1511 · Cited by 253
Lerer, B. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00293-2 · Cited by 239
Davis, D. (1998) · The International Journal of Psychiatry in Medicine · doi:10.2190/ua3r-jx9w-mhr5-rc81 · Cited by 240
Efficacy of Prophylactic Antibiotic Therapy in Spinal Surgery: A Meta-analysis
Barker, F. G. (2002) · Neurosurgery · doi:10.1097/00006123-200208000-00017 · Cited by 166
Cumulative Meta-Analysis: A Consideration of Indicators of Sufficiency and Stability
Mullen, B. R., Muellerleile, P. A., & Bryant, B. (2001) · Personality and Social Psychology Bulletin · doi:10.1177/01461672012711006 · Cited by 254
Graphical displays for meta-analysis: An overview with suggestions for practice
Anzures‐Cabrera, J., & Higgins, J. P. T. (2010) · Research Synthesis Methods · doi:10.1002/jrsm.6 · Cited by 233
Muir, J., Mant, D., Jones, L., & Yudkin, P. L. (1994) · BMJ · doi:10.1136/bmj.308.6924.308 · Cited by 231
Nikolopoulos, G. K., Paraskevis, D. N., Hatzitheodorou, E., Moschidis, Z., Sypsa, V., Zavitsanos, X., Kalapothaki, V., & Hatzakis, A. E. (2009) · Clinical Infectious Diseases · doi:10.1086/599110 · Cited by 230
Acute Myocardial Infarction in the Medicare Population
Udvarhelyi, I. S. (1992) · JAMA · doi:10.1001/jama.1992.03490180062027 · Cited by 242
Predictive ability of meta-analyses of randomised controlled trials
Villar, J., Carroli, G., & Belizán, J. M. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90646-0 · Cited by 223
Brouder, S. M., & Macpherson, H. G. (2014) · Agriculture Ecosystems & Environment · doi:10.1016/j.agee.2013.08.010 · Cited by 227
XRCC1Polymorphisms and Cancer Risk: A Meta-analysis of 38 Case-Control Studies
Hu, Z., Ma, H., Chen, F., Wei, Q., & Shen, H. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0793 · Cited by 219
Pulsed Radiofrequency: Current Clinical and Biological Literature Available
Cahana, A., Zundert, J. H. M. V., Macrea, L. M., van Kleef, M., & Sluijter, M. E. (2006) · Pain Medicine · doi:10.1111/j.1526-4637.2006.00148.x · Cited by 219
Schmid, C. H., Lau, J., McIntosh, M. W., & Cappelleri, J. C. (1998) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19980915)17:17 · Cited by 211
Self-citationPublication bias as a threat to the validity of meta-analytic results
Rothstein, H. R. (2008) · Journal of Experimental Criminology · doi:10.1007/s11292-007-9046-9 · Cited by 216
Lee, V. C., Rhew, D. C., Dylan, M. L., Badamgarav, E., Braunstein, G. D., & Weingarten, S. R. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-9-200411020-00011 · Cited by 210
Essential Epidemiology: An Introduction for Students and Health Professionals
Webb, P. M., & Bain, C. (2012) · Cited by 209
Device Closure of Patent Foramen Ovale After Stroke
Kent, D. M., Dahabreh, I. J., Ruthazer, R., Furlan, A. J., Reisman, M., Carroll, J. D., Saver, J. L., Smalling, R. W., Jüni, P., Mattle, H. P., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.12.023 · Cited by 207
Karassa, F. B., Trikalinos, T. A., & Ioannidis, J. P. A. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10306 · Cited by 209
CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials
Hopewell, S., Chan, A.-W., Collins, G. S., Hróbjartsson, A., Moher, D., Schulz, K. F., Tunn, R., Aggarwal, R., Berkwits, M., Berlin, J. A., et al. (2025) · BMJ · doi:10.1136/bmj-2024-081124 · Cited by 205
Prochaska, J. J., & Hilton, J. F. (2012) · BMJ · doi:10.1136/bmj.e2856 · Cited by 202
Saito, Y., Oyama, K., Tsujita, K., Yasuda, S., & Kobayashi, Y. (2022) · Journal of Cardiology · doi:10.1016/j.jjcc.2022.07.003 · Cited by 216
Woods, K., & Fletcher, N. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92024-9 · Cited by 202
Lehmann, D. J., Cortina-Borja, M., Warden, D. R., Smith, A. D., Sleegers, K., Prince, J. A., van Duijn, C. M., & Kehoe, P. G. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi202 · Cited by 199
Zintzaras, E., Stefanidis, I., Mauro Santos, A., & Vidal, F. (2006) · Hepatology · doi:10.1002/hep.21023 · Cited by 201
Hooijmans, C. R., IntHout, J., Ritskes-Hoitinga, M. J., & Rovers, M. M. (2014) · ILAR Journal · doi:10.1093/ilar/ilu042 · Cited by 203
Thoracic imaging tests for the diagnosis of COVID-19
Islam, N., Ebrahimzadeh, S., Salameh, J., Kazi, S., Fabiano, N., Treanor, L. M., Absi, M., Hallgrimson, Z., Leeflang, M., Hooft, L., et al. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013639.pub4 · Cited by 202
Fisher, M. L., Gottlieb, S. S., Plotnick, G. D., Greenberg, N., Patten, R. D., Bennett, S. K., & Hamilton, B. P. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90641-6 · Cited by 193
Evolution of treatment effects over time: Empirical insight from recursive cumulative metaanalyses
Ioannidis, J. P. A., & Lau, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.831 · Cited by 190
Self-citationNoninvasive Ventilation and Survival in Acute Care Settings
Cabrini, L., Landoni, G., Oriani, A., Plumari, V. P., Nobile, L., Greco, M., Pasin, L., Beretta, L., & Zangrillo, A. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000819 · Cited by 192
Savulescu, J., Chalmers, I., & Blunt, J. (1996) · BMJ · doi:10.1136/bmj.313.7069.1390 · Cited by 189
Randomised controlled trial of laparoscopic versus open repair of inguinal hernia: early results
Lawrence, K., McWhinnie, D. L., Goodwin, A., Doll, H., Gordon, A., Gray, A. M., Britton, J., & Collin, J. (1995) · BMJ · doi:10.1136/bmj.311.7011.981 · Cited by 189
HTA 101 INTRODUCTION TO HEALTH TECHNOLOGY ASSESSMENT
Goodman, C. S., & Church, F. (2004) · Cited by 185
Efficacy and safety of intrapartum electronic fetal monitoring: an update
Thacker, S., Stroup, D. F., & Peterson, H. B. (1995) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(95)80027-1 · Cited by 185
How much evidence does it take? A cumulative meta‐analysis of outcomes of simulation‐based education
Cook, D. A. (2014) · Medical Education · doi:10.1111/medu.12473 · Cited by 183
Olatidoye, A. G., Wu, A. H. B., Feng, Y., & Waters, D. D. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00200-8 · Cited by 183
Nikolopoulos, G. K., Dimou, N. L., Hamodrakas, S. J., & Bagos, P. G. (2008) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2008.01298.x · Cited by 181
Determination of the clinical importance of study results
Man‐Son‐Hing, M., Laupacis, A., O’Rourke, K., Molnar, F., Mahon, J., Chan, K. B. Y., & Wells, G. A. (2002) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2002.11111.x · Cited by 182
Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time
Trikalinos, T. A., Churchill, R., Ferri, M., Leucht, S., Tuunainen, A., Wahlbeck, K., & Ioannidis, J. P. A. (2004) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2004.02.018 · Cited by 177
Thrombolytic therapy of pulmonary embolism
Thabut, G., Thabut, D., Myers, R. P., Bernard‐Chabert, B., Marrash-Chahla, R., Mal, H., & Fournier, M. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02381-1 · Cited by 175
Beta-blocker therapy in the cardiac arrhythmia suppression trial
Kennedy, H. L., Brooks, M. M., Barker, A. H., Bergstrand, R. H., Huther, M. L., Beanlands, D. S., Bigger, J. T., Goldstein, S., & The CAST Investigators (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90308-5 · Cited by 172
Systematic Review and Meta‐Analysis
Bouter, L. M., Zeegers, M., & Lee, T. (2023) · Wiley eBooks · doi:10.1002/9781394323104.ch11 · Cited by 183
Inadequate Prescription-Drug Coverage for Medicare Enrollees — A Call to Action
Soumerai, S. B., & Ross‐Degnan, D. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903043400909 · Cited by 168
There’s more than one way to conduct a replication study: Beyond statistical significance.
Anderson, S. F., & Maxwell, S. E. (2016) · Psychological Methods · doi:10.1037/met0000051 · Cited by 167
van Dixhoorn, J., & White, A. R. (2005) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000166451.38593.de · Cited by 166
Cepeda, M. S., Lau, J., & Carr, D. B. (2002) · Clinical Journal of Pain · doi:10.1097/00002508-200207000-00002 · Cited by 162
Self-citationTrends in treatment and outcomes for acute myocardial infarction: 1975–1995
Heidenreich, P. A., & McClellan, M. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00712-9 · Cited by 166
Systematic review and meta-analysis: techniques and a guide for the academic surgeon.
Phan, K. H., Tian, D. H., Cao, C. Q., Black, D. A., & Yan, T. D. (2015) · PubMed Central · doi:10.3978/j.issn.2225-319x.2015.02.04 · Cited by 167
Defined-Formula Diets versus Steroids in the Treatment of Active Crohn's Disease A Meta-Analysis
Messori, A., Trallori, G., D'Albasio, G., Milla, M., Vannozzi, G., & Pacini, F. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609004877 · Cited by 164
Yang, Y., Tsai, C., & Lu, C. Y. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09049.x · Cited by 162
Mittendorf, R. L., Aronson, M. P., Berry, R. E., Williams, M. A., Kupelnick, B., Klickstein, A., Herbst, A. L., & Chalmers, T. C. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90266-l · Cited by 156
Self-citationPooling Research Results: Benefits and Limitations of Meta-Analysis
Ioannidis, J. P. A., & Lau, J. (1999) · The Joint Commission Journal on Quality Improvement · doi:10.1016/s1070-3241(16)30460-6 · Cited by 157
Self-citationMangano, D. T. (1997) · JAMA · doi:10.1001/jama.277.4.325 · Cited by 168
Peat, G., Riley, R. D., Croft, P. R., Morley, K. I., Kyzas, P., Moons, K. G. M., Perel, P., Steyerberg, E. W., Schroter, S., Altman, D. G., et al. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001671 · Cited by 152
When and how to update systematic reviews
Moher, D., Tsertsvadze, A., Tricco, A. C., Eccles, M., Grimshaw, J., Sampson, M., & Barrowman, N. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.mr000023.pub3 · Cited by 157
Meta-analysis of the association of β2-adrenergic receptor polymorphisms with asthma phenotypes
Contopoulos‐Ioannidis, D. G., MANOLI, E., & Ioannidis, J. P. A. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.12.1119 · Cited by 150
Viskin, S., Kitzis, I., Lev, E. I., Zak, Z., Heller, K., Villa, Y., Zajarías, A., Laniado, S., & Belhassen, B. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)00552-2 · Cited by 146
de Vries, R. B. M., Wever, K. E., Avey, M. T., Stephens, M. L., Sena, E. S., & Leenaars, M. (2014) · ILAR Journal · doi:10.1093/ilar/ilu043 · Cited by 165
Willingly or grudgingly? A meta-analysis on the willingness-to-pay for renewable energy use
Soon, J., & Ahmad, S.-A. (2015) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2015.01.041 · Cited by 155
Kraemer, H. C., Gardner, C., Brooks, J. O., & Yesavage, J. A. (1998) · Psychological Methods · doi:10.1037/1082-989x.3.1.23 · Cited by 141
The FcγRIIIA-F158 allele is a risk factor for the development of lupus nephritis: A meta-analysis
Karassa, F. B., Trikalinos, T. A., Ioannidis, J. P. A., & FcγRIIIA-SLE meta-analysis investigators (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00873.x · Cited by 142
Attention should be given to multiplicity issues in systematic reviews
Bender, R., Bunce, C., Clarke, M. J., Gates, S., Lange, S., Pace, N. L., & Thorlund, K. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2008.03.004 · Cited by 138
Pedersen, A., Zachariae, R., & Bovbjerg, D. H. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181f1d003 · Cited by 137
Meta-analysis of the association between cigarette smoking and peripheral arterial disease
Lu, L., Mackay, D., & Pell, J. P. (2013) · Heart · doi:10.1136/heartjnl-2013-304082 · Cited by 137
Choudhry, N. K., Setoguchi, S., Levin, R., Winkelmayer, W. C., & Shrank, W. H. (2008) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1671 · Cited by 136
Efficacy of Prophylactic Antibiotics for Craniotomy
Barker, F. G. (1994) · Neurosurgery · doi:10.1227/00006123-199409000-00017 · Cited by 134
Garlic Powder in the Treatment of Moderate Hyperlipidaemia: A Controlled Trial and Meta-Analysis
Neil, H. A. W., Silagy, C. A., Lancaster, T., Hodgeman, J., Vos, K., Moore, J. W., Jones, L., Cahill, J., & Fowler, G. H. (1996) · Journal of the Royal College of Physicians of London · doi:10.1016/s0035-8819(25)00368-x · Cited by 133
Immunizations and risk of multiple sclerosis: systematic review and meta-analysis
Farez, M., & Correale, J. D. (2011) · Journal of Neurology · doi:10.1007/s00415-011-5984-2 · Cited by 132
European Secondary Prevention Study Group, & Woods, K. L. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90732-1 · Cited by 131
Collaborative Chronic Care Models for Mental Health Conditions
Miller, C. J., Grogan‐Kaylor, A. C., Perron, B. E., Kilbourne, A. M., Woltmann, E. M., & Bauer, M. S. (2013) · Medical Care · doi:10.1097/mlr.0b013e3182a3e4c4 · Cited by 135
Lifelong Learning in the 21st Century and Beyond
Collins, J. (2009) · Radiographics · doi:10.1148/rg.292085179 · Cited by 128
Psychological treatments in cardiac rehabilitation
Linden, W. (2000) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(99)00094-x · Cited by 128
Cost-effectiveness of captopril therapy after myocardial infarction
Tsevat, J., Duke, D., Goldman, L., Pfeffer, M. A., Lamas, G. A., Soukup, J. R., Kuntz, K. M., & Lee, T. H.-Y. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00284-1 · Cited by 128
Clarke, M., Brice, A., & Chalmers, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102670 · Cited by 120
Sweet Solutions to Reduce Procedural Pain in Neonates: A Meta-analysis
Harrison, D. M., Larocque, C., Bueno, M., Stokes, Y., Turner, L., Hutton, B., & Stevens, B. (2016) · PEDIATRICS · doi:10.1542/peds.2016-0955 · Cited by 126
Hanratty, B., Lawlor, D. A., Robinson, M. B., Sapsford, R. J., Greenwood, D. C., & Hall, A. (2000) · Journal of Epidemiology & Community Health · doi:10.1136/jech.54.12.912 · Cited by 127
Flores‐Mateo, G., Grau, M., O’Flaherty, M., Ramos, R., Elosúa, R., Violán, C., Quesada, M., Martí‐Lluch, R., Sala, J., Marrugat, J., et al. (2011) · Revista Española de Cardiología · doi:10.1016/j.recesp.2011.05.033 · Cited by 127
Ntais, C., Polycarpou, A., & Ioannidis, J. P. A. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.176.14.1 · Cited by 123
Denollet, J., & Brutsaert, D. L. (2001) · Circulation · doi:10.1161/hc4201.097940 · Cited by 121
Zintzaras, E. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.10.1077 · Cited by 122
Secondary prevention after acute myocardial infarction
Heller, R. F., Knapp, J., Valenti, L., & Dobson, A. J. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)91058-p · Cited by 122
Evidence-based Laboratory Medicine: Supporting Decision-Making
Price, C. P. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.8.1041 · Cited by 122
Trends in the use of drag therapies in patients with acute myocardial infarction: 1988 to 1992
Pashos, C. L., Normand, S. T., Garfinkle, J. B., Newhouse, J. P., Epstein, A. M., & McNeil, B. J. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90585-1 · Cited by 120
Evidence-Based Research Series-Paper 1: What Evidence-Based Research is and why is it important?
Robinson, K. A., Brunnhuber, K., Ciliska, D., Juhl, C. B., Christensen, R., & Lund, H. (2021) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2020.07.020 · Cited by 146
Crowe, B. J., Xia, H. A., Berlin, J. A., Watson, D. J., Shi, H., Lin, S. L., Kuebler, J., Schriver, R. C., Santanello, N. C., Rochester, G., et al. (2009) · Clinical Trials · doi:10.1177/1740774509344101 · Cited by 118
Nony, P., Boissel, J., Lièvre, M., Leizorovicz, A., Haugh, M. C., Fareh, S., & Breyne, B. D. (1994) · European Journal of Clinical Pharmacology · doi:10.1007/bf00192547 · Cited by 118
Commentary: Meta-analysis of Individual Participants' Data in Genetic Epidemiology
Ioannidis, J. P. A. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf031 · Cited by 117
Williams, H. (2008) · American Journal of Clinical Dermatology · doi:10.2165/11595500-000000000-00000 · Cited by 71
Marques, E. M. R., Jones, H. E., Elvers, K. T., Pyke, M., Blom, A. W., & Beswick, A. D. (2014) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-15-220 · Cited by 116
Association of paraoxonase 1 gene polymorphisms with risk of Parkinson’s disease: a meta-analysis
Zintzaras, E., & Hadjigeorgiou, G. M. (2004) · Journal of Human Genetics · doi:10.1007/s10038-004-0176-x · Cited by 114
Should morbidity replace mortality as an endpoint for clinical trials in intensive care?
Petros, A., Marshall, J. C., & van Saene, H. K. F. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90347-x · Cited by 114
Metadata
- Authors
- Lau, J., Antman, E. M., Jimenez-Silva, J., Kupelnick, B., Mosteller, F., & Chalmers, T. C.
- Affiliations
- Tufts University (US)
- Brigham and Women's Hospital (US)
- United States Department of Veterans Affairs (US)
- Harvard University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1992-07-23
- Volume
- 327
- Issue
- 4
- Pages
- 248-254
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2320350515
- Cited by
- 1,140
- References
- 54
- Citations by year
- 2026: 17 · 2025: 14 · 2024: 17 · 2023: 25 · 2022: 28 · 2021: 25 · 2020: 25 · 2019: 21 · 2018: 28 · 2017: 19 · 2016: 38 · 2015: 36 · 2014: 61 · 2013: 32 · 2012: 49
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agency for Healthcare Research and Quality (R01 HS-05936, P0RT-1-PO1-HS 06341-02)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Keywords
- myocardial infarction, acute myocardial infarction treatment, streptokinase, thrombolysis, mortality reduction, prophylaxis
- MeSH terms
- Humans, Myocardial Infarction, Streptokinase, Meta-Analysis as Topic, Thrombolytic Therapy, Confidence Intervals, Odds Ratio, Randomized Controlled Trials as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
