Large Meta-Analysis Establishes the ACE Insertion-Deletion Polymorphism as a Marker of Alzheimer's Disease
Open accessAbstract
Apolipoprotein E epsilon4 (APOE*4) is the only fully established susceptibility allele for Alzheimer's disease. One of the most studied candidates is the insertion (I)/deletion (D) polymorphism (indel) of the gene for angiotensin I-converting enzyme (ACE). This study aimed to clarify its association with Alzheimer's disease. The meta-analysis included 39 samples, comprising 6,037 cases of Alzheimer's disease and 12,099 controls, using mainly primary data. Potential interactions with gender, age, ethnic group, and carrier status of the apolipoprotein E epsilon4 allele were all examined. D homozygotes were at reduced risk of Alzheimer's disease (odds ratio = 0.81, 95% confidence interval: 0.72, 0.90; corrected p = 0.0004); I homozygotes showed no association with Alzheimer's disease, while heterozygotes were at increased risk. Although there were clear differences among the three ethnic groups examined (North Europeans, South Caucasians, and East Asians), in all groups D homozygotes were at reduced risk. These results confirm the association of the angiotensin I-converting enzyme indel with Alzheimer's disease across diverse populations, although this is probably due to linkage disequilibrium with the true risk factor. Further, in North Europeans, both association and Hardy-Weinberg analysis suggested partial heterosis, that is, an increased risk for heterozygotes, due to a hidden interaction with another, as yet unknown, risk factor. This interaction warrants further investigation.
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The ACE locus is a known blood pressure and AD association.
“which is a known blood pressure and AD association”
From Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits (2021) · cites this paper as [32]
ACE and ADAM10 were previously reported as Alzheimer's disease candidate genes but were not replicated in some subsequent studies.
“ACE and ADAM10 were previously reported as Alzheimer’s disease candidate genes18–22 but were not replicated in some subsequent studies23–25.”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [22]
Candidate gene studies have associated ACE variants with Alzheimer's disease risk, including a strong association in the Wadi Ara community.
“Candidate gene studies have associated ACE variants with Alzheimer’s disease risk20,22,79, including a strong association in the Wadi Ara, an Israeli Arab community with high risk of Alzheimer’s disease21.”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [22]
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689 · see citing works
Gentleman R: R: A language for data analysis and graphics
Ihaka, R., & Gentleman, R. (1996) · Journal of Computational and Graphical Statistics · doi:10.1080/10618600.1996.10474713 · Cited by 11,747 · see citing works
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,167 · see citing works
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P., & Soubrier, F. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114844 · Cited by 3,767 · see citing works
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859 · see citing works
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499 · see citing works
Systematic Reviews in Health Care : Meta-Analysis in Context
Egger, M., Smith, G. D., & Altman, D. G. (2000) · Cited by 2,312 · see citing works
Systematic Reviews in Health Care: Meta‐Analysis in Context
(2001) · doi:10.1002/9780470693926 · Cited by 1,693 · see citing works
Tiret, L., Rigat, B. A., Visvikis‐Siest, S., Breda, C., Corvol, P. L., Cambien, F., & Soubrier, F. (1992) · Europe PMC (PubMed Central) · Cited by 1,174 · see citing works
Cumulative Meta-Analysis of Therapeutic Trials for Myocardial Infarction
Lau, J., Antman, E. M., Jimenez-Silva, J., Kupelnick, B., Mosteller, F., & Chalmers, T. C. (1992) · New England Journal of Medicine · doi:10.1056/nejm199207233270406 · Cited by 1,140 · see citing works
Mistyping ACE heterozygotes.Preprint
Shanmugam, V., Sell, K. W., & Saha, B. K. (1993) · Genome Research · doi:10.1101/gr.3.2.120 · Cited by 512 · see citing works
Incidence and Risk of Dementia: The Rotterdam study
Ott, A., Breteler, M. M. B., Harskamp, F. V., Stijnen, T., & Hofman, A. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009489 · Cited by 455 · see citing works
Samani, N. J., Thompson, J. R., O’Toole, L., Channer, K. S., & WOODS, K. L. (1996) · Circulation · doi:10.1161/01.cir.94.4.708 · Cited by 414 · see citing works
Staessen, J. A., Wang, J. G., Ginocchio, G., Petrov, V., Saavedra, A. P., Soubrier, F., VLIETINCK, R. F., & Fagard, R. H. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715120-00059 · Cited by 383 · see citing works
Keavney, B. D., McKenzie, C. A., Parish, S., Palmer, A., Clark, S. J., Youngman, L. D., Délepine, M., Lathrop, M. G., Peto, R., & Collins, R. (2000) · The Lancet · doi:10.1016/s0140-6736(00)82009-7 · Cited by 345 · see citing works
Comings, D. E., & MacMurray, J. P. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3015 · Cited by 333 · see citing works
Hu, J.-G., Igarashi, A., Kamata, M., & Nakagawa, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104068200 · Cited by 307 · see citing works
Warn, D. E., Thompson, S. G., & Spiegelhalter, D. J. (2002) · Statistics in Medicine · doi:10.1002/sim.1189 · Cited by 277 · see citing works
Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease
Kehoe, P. G., Russ, C., McIlroy, S., Williams, H., Holmans, P., Holmes, C., Liolitsa, D., Vahidassr, D., Powell, J., McGleenon, B., et al. (1999) · Nature Genetics · doi:10.1038/5009 · Cited by 260 · cited 8× · see citing works
“(1) Cardiff, Wales 198 77 NINCDS-ADRDA probable”
BackgroundMethodResultInfluentialSelf-citationEffects of brain-penetrating ACE inhibitors on Alzheimer disease progression
Ohrui, T., Tomita, N., Satoh‐Nakagawa, T., Matsui, T., Maruyama, M., Niwa, K., Arai, H., & Sasaki, H. (2004) · Neurology · doi:10.1212/01.wnl.0000140705.23869.e9 · Cited by 246 · see citing works
Savaskan, E., Höck, C., Olivieri, G., Bruttel, S., Rosenberg, C., Hulette, C., & Müller-Spahn, F. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00259-1 · Cited by 217 · see citing works
Meta-analysis of the ACE gene in ischaemic stroke
Sharma, P. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.2.227 · Cited by 174 · see citing works
ACE Gene Polymorphism: Ischemic Heart Disease and Longevity in 10 150 Individuals
Agerholm-Larsen, B., Nordestgaard, B. G., Steffensen, R., Sørensen, T. I. A., Jensen, G. B., & Tybjærg‐Hansen, A. (1997) · Circulation · doi:10.1161/01.cir.95.10.2358 · Cited by 166 · see citing works
Arregui, A., Perry, E. K., Rossor, M. N., & Tomlinson, B. E. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb07930.x · Cited by 156 · see citing works
Prince, J. A., Feuk, L., Sawyer, S. L., Gottfries, J., Ricksten, A., Nägga, K., Bogdanović, N., Blennow, K., & Brookes, A. J. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200651 · Cited by 141 · see citing works
Self-citationBarnes, N. M., Cheng, C. H. K., Costall, B., Naylor, R. J., Williams, T. J., & Wischik, C. M. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90584-d · Cited by 132 · see citing works
Angiotensin‐Converting Enzyme Inhibitors and Incidence of Alzheimer's Disease in Japan
Ohrui, T., Matsui, T., Yamaya, M., Arai, H., Ebihara, S., Maruyama, M., & Sasaki, H. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52178_7.x · Cited by 127 · see citing works
A study of French centenarians: are ACE and APOE associated with longevity?
Blanché, H., Cabanne, L., Sahbatou, M., & Thomas, G. (2001) · Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie · doi:10.1016/s0764-4469(00)01274-9 · Cited by 126 · see citing works
Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · see citing works
Chapman, J., Wang, N., Treves, T. A., Korczyn, A. D., & Bornstein, N. M. (1998) · Stroke · doi:10.1161/01.str.29.7.1401 · Cited by 123 · see citing works
The ACE gene and Alzheimer's disease susceptibility
Narain, Y., Yip, A., Murphy, T., Brayne, C., Easton, D., Evans, J. G., Xuereb, J., Cairns, N., Esiri, M., Furlong, R., et al. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.9.695 · Cited by 121 · see citing works
Haplotypes extending across ACE are associated with Alzheimer's disease
Kehoe, P. G. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg094 · Cited by 119 · see citing works
Self-citationFogarty, D. G., Maxwell, A. P., Doherty, C., Hughes, A. E., & Nevin, N. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92050-8 · Cited by 109 · see citing works
Alzheimer disease risk and genetic variation in ACE
Elkins, J. S., Douglas, V. C., & Johnston, S. C. (2004) · Neurology · doi:10.1212/01.wnl.0000106823.72493.ff · Cited by 108 · see citing works
Álvarez, R., Álvarez, V., Lahoz, C., Martínez, C., Peña, J., Sanchez, J. M., Guisasola, L., Salas-Puig, J., Morís, G., Vidal, J. A., et al. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.6.733 · Cited by 105 · see citing works
Nagy, Z., Esiri, M. M., Hindley, N., Joachim, C. L., Morris, J. H., King, E. M.-F., McDonald, B., Litchfield, S., Barnetson, L. P. D., Jobst, K. A., et al. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017050 · Cited by 96 · see citing works
Self-citationCox, R. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.23.2969 · Cited by 96 · see citing works
Association Between Angiotensin-Converting Enzyme and Alzheimer Disease
Farrer, L. A., Sherbatich, T., Keryanov, S. A., Коровайцева, Г. И., Rogaeva, E. A., Petruk, S., Premkumar, S., Moliaka, Y., Song, Y., Pei, Y., et al. (2000) · Archives of Neurology · doi:10.1001/archneur.57.2.210 · Cited by 94 · see citing works
Galinsky, D., Tysoe, C. J., Brayne, C., Easton, D. F., Huppert, F. A., Dening, T. R., Paykel, E. S., & Rubinsztein, D. C. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(96)06027-3 · Cited by 89 · see citing works
Angiotensin-Converting Enzyme Gene Polymorphism and Carotid Artery Wall Thickness
Sayed‐Tabatabaei, F. A., Houwing‐Duistermaat, J. J., van Duijn, C. M., & Witteman, J. C. M. (2003) · Stroke · doi:10.1161/01.str.0000077926.49330.64 · Cited by 88 · see citing works
Perry, R. T., Collins, J. S., Harrell, L. E., Acton, R. T., & Go, R. C. P. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1371 · Cited by 81 · see citing works
Hu, J., Miyatake, F., Aizu, Y., Nakagawa, H., Nakamura, S., Tamaoka, A., Takahash, R., Urakami, K., & Shoji, M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00827-7 · Cited by 74 · see citing works
Genetic polymorphisms in older subjects with vascular or Alzheimer's dementia
Zuliani, G., Blè, A., Zanca, R., Munari, M. R., Zurlo, A., Vavalle, C., Atti, A. R., & Fellin, R. (2001) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2001.103005304.x · Cited by 74 · see citing works
Scacchi, R., de Bernardini, L., Mantuano, E., Vilardo, T., Donini, L. M., Ruggeri, M., Gemma, A. T., Pascone, R., & Corbo, R. M. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017045 · Cited by 65 · see citing works
Panza, F. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00154-2 · Cited by 65 · see citing works
Aydemir, T., �zt�rk, R., Bozkaya, L. A., & Tarhan, L. (2000) · Cell Biochemistry and Function · doi:10.1002/(sici)1099-0844(200006)18:2 · Cited by 64 · see citing works
Lehmann, D., Williams, J., McBroom, J., & Smith, A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00464-x · Cited by 63 · see citing works
Self-citationLong-Term Inhibition of Renin-Angiotensin System Sustains Memory Function in Aged Dahl Rats
Hirawa, N., Uehara, Y., Kawabata, Y., Numabe, A., Gomi, T., Ikeda, T., Suzuki, T., Goto, A., Toyo‐oka, T., & Omata, M. (1999) · Hypertension · doi:10.1161/01.hyp.34.3.496 · Cited by 62 · see citing works
ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala
Sleegers, K., den Heijer, T., van Dijk, E. J., Albert Hofman, D., Bertoli‐Avella, A. M., Koudstaal, P. J., Breteler, M. M. B., & van Duijn, C. M. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.011 · Cited by 61 · see citing works
Self-citationSeripa, D., Forno, G. D., Matera, M. G., Gravina, C., Margaglione, M., Palermo, M., Wekstein, D., Antuono, P., Davis, D., Daniele, A., et al. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00040-x · Cited by 61 · see citing works
Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease
Crawford, F., Abdullah, L. I., Schinka, J. A., Suo, Z., Gold, M., Duara, R., & Mullan, M. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00791-6 · Cited by 57 · see citing works
Angiotensin converting enzyme deletion allele in different kinds of dementia disorders
Palumbo, B., Cadini, D., Nocentini, G., Filipponi, E., Fravolini, M. L., & Senin, U. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00329-8 · Cited by 51 · see citing works
Mattila, K. M., Rinne, J. O., Röyttä, M., Laippala, P., Pietilä, T., Kalimo, H., Koivula, T., Frey, H., & Lehtimäki, T. J. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.10.766 · Cited by 51 · see citing works
Myllykangas, L., Polvikoski, T. M., Sulkava, R. O., Verkkoniemi, A., Tienari, P. J., Niinistö, L., Kontula, K., Hardy, J., Haltia, M., & Pérez‐Tur, J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01467-1 · Cited by 50 · see citing works
Cheng, C., Hong, C., Liu, H.-C., Liu, T., & Tsai, S. (2002) · European Neurology · doi:10.1159/000047943 · Cited by 50 · see citing works
Katzov, H., Bennet, A. M., Kehoe, P. G., Wiman, B., Gatz, M., Blennow, K., Lenhard, B., Pedersen, N. L., Fairé, U. D., & Prince, J. A. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh286 · Cited by 48 · see citing works
Self-citationGenetic Analysis of Vascular Factors in Alzheimer's Disease
Wakutani, Y., Kowa, H., Kusumi, M., YAMAGATA, K., Wada‐Isoe, K., Adachi, Y., Takeshima, T., Urakami, K., & Nakashima, K. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04820.x · Cited by 45 · see citing works
Lendon, C. L., Thaker, U., Harris, J. M., McDonagh, A. M., Lambert, J., Chartier‐Harlin, M., Iwatsubo, T., Pickering-Brown, S. M., & Mann, D. M. A. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00553-0 · Cited by 44 · see citing works
Review: The renin-angiotensin-aldosterone system and Alzheimer's disease?
Kehoe, P. G. (2003) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2003.017 · Cited by 40 · see citing works
Self-citationThe angiotensin I converting enzyme gene as a susceptibility factor for dementia
Richard, F., Fromentin–David, I., Ricolfi, F., Ducimetière, P., Menza, C. D., Amouyel, P., & Helbecque, N. (2001) · Neurology · doi:10.1212/wnl.56.11.1593 · Cited by 40 · see citing works
Monastero, R., Caldarella, R., Mannino, M., Cefalu, A. B., Lopez, G., Noto, D., Camarda, C., Camarda, L. K. C., Notarbartolo, A., Averna, M. R., et al. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01182-5 · Cited by 38 · see citing works
Yang, J. D., Feng, G., Zhang, J., Lin, Z., Shen, T., Breen, G. D., Clair, D. S., & He, L. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01591-3 · Cited by 37 · see citing works
Common variants of ACE contribute to variable age-at-onset of Alzheimer’s disease
Kehoe, P. G., Katzov, H., Andreasen, N., Gatz, M., Wilcock, G. K., Cairns, N. J., Palmgren, J., Fairé, U. D., Brookes, A. J., Pedersen, N. L., et al. (2004) · Human Genetics · doi:10.1007/s00439-004-1093-y · Cited by 37 · see citing works
Self-citationShimokata, H., Yamada, Y., Nakagawa, M., Okubo, R., Saido, T. C., Funakoshi, A., Miyasaka, K., Ohta, S., Tsujimoto, G., Tanaka, M., et al. (2000) · Journal of Epidemiology · doi:10.2188/jea.10.1sup_46 · Cited by 36 · see citing works
Panza, F. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.8.1159 · Cited by 29 · see citing works
Camelo, D., Arboleda, G., Yunis, J. J., Pardo, R., Arango, G. J., Solano, E., López, L., Hedmont, D., & Arboleda, H. (2003) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2003.10.008 · Cited by 27 · see citing works
da Cruz, I. B. M., Oliveira, G., Taufer, M., Leal, N. F., Schwanke, C. H. A., Glock, L., Moriguchi, Y., & Moriguchi, E. H. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.9.m851 · Cited by 27 · see citing works
No association between DCP1 genotype and late‐onset Alzheimer disease
Buss, S., Müller‐Thomsen, T., Hock, C., Alberici, A., Binetti, G. G., Nitsch, R. M., Gal, A., & Finckh, U. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10306 · Cited by 24 · see citing works
Association Between Angiotensin-Converting Enzyme Gene Polymorphism and Coronary Artery Disease
İşbir, T., Yılmaz, H., Ağaçhan, B., Aydın, M., & Isbir, C. S. (1999) · IUBMB Life · doi:10.1080/713803502 · Cited by 23 · see citing works
Angiotensin converting enzyme and memory: preclinical and clinical data.
Sudilovsky, A., Turnbull, B. A., Croog, S. H., & Crook, T. (1987) · PubMed · Cited by 15 · see citing works
Carbonell, J., Allen, R., Kalsi, G., McQuillin, A., Livingston, G., Katona, C., Walker, Z., Katz, A., Rands, G., Stevens, T., et al. (2003) · Psychiatric Genetics · doi:10.1097/00041444-200303000-00008 · Cited by 10 · see citing works
Lack of association between ace polymorphism and Alzheimer's disease in southern Italy.
Panza, F., Solfrizzi, V., D'Introno, A., Capurso, C., Colacicco, A., Argentieri, G., & Capurso, A. (2002) · Archives of gerontology and geriatrics. Supplement · doi:10.1016/s0167-4943(02)00140-1 · Cited by 9 · see citing works
Wu, C., Zhou, D., Guan, Z., Fan, J., & Qiao, Y. (2002) · PubMed · Cited by 6 · see citing works
Nacmias, B., Tedde, A., Forleo, P., Marcon, G., Piacentini, S., & Sorbi, S. (1999) · Institutional Research Information System (University of Udine) · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 79 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Alzheimer Disease Genetics Consortium (ADGC), Kunkle, B. W., The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, P. A. E. R. F. A. D. C. (., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0358-2 · Cited by 2,946 · see citing works
Self-citationSystematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., & Tanzi, R. E. (2007) · Nature Genetics · doi:10.1038/ng1934 · Cited by 1,857 · see citing works
GWAS on family history of Alzheimer’s disease
Marioni, R. E., Harris, S. E., Zhang, Q., McRae, A. F., Hagenaars, S. P., Hill, W. D., Davies, G., Ritchie, C. W., Gale, C. R., Starr, J. M., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0150-6 · Cited by 564 · see citing works
Defining the relationship between hypertension, cognitive decline, and dementia: a review
Walker, K. A., Power, M. C., & Gottesman, R. F. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0724-3 · Cited by 394 · see citing works
Miners, J. S., Baig, S., Palmer, J. C., Palmer, L. E., Kehoe, P. G., & Love, S. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00132.x · Cited by 380 · see citing works
Self-citationSayed-Tabatabaei, F., Oostra, B., Isaacs, A., van Duijn, C. V., & Witteman, J. (2006) · Circulation Research · doi:10.1161/01.res.0000223145.74217.e7 · Cited by 306 · see citing works
Hemming, M. L., & Selkoe, D. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508460200 · Cited by 330 · see citing works
Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes
Zuroff, L. R., Daley, D. A., Black, K. L., & Koronyo‐Hamaoui, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2463-7 · Cited by 275 · see citing works
The CNS renin-angiotensin system
Halbach, O. V. B. U., & Albrecht, D. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0190-8 · Cited by 251 · see citing works
The Worldwide Challenge of the Dementias: A Role for B Vitamins and Homocysteine?
Smith, A. D. (2008) · Food and Nutrition Bulletin · doi:10.1177/15648265080292s119 · Cited by 216 · see citing works
Self-citationKehoe, P. G., Wong, S., AL Mulhim, N., Palmer, L. E., & Miners, J. S. (2016) · Alzheimer's Research & Therapy · doi:10.1186/s13195-016-0217-7 · Cited by 203 · see citing works
Self-citationVariants within the COL5A1 gene are associated with Achilles tendinopathy in two populations
September, A. V., Cook, J., Handley, C. J., van der Merwe, L., Schwellnus, M. P., & Collins, M. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.048793 · Cited by 198 · see citing works
Cheng, Y., Tian, D., & Wang, Y.-J. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00195-1 · Cited by 195 · see citing works
Are amyloid‐degrading enzymes viable therapeutic targets in Alzheimer’s disease?
Nalivaeva, N., Beckett, C. S., Belyaev, N. D., & Turner, A. J. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07510.x · Cited by 178 · see citing works
Zou, K., Yamaguchi, H., Akatsu, H., Sakamoto, T., Ko, M.-H., Mizoguchi, K., Gong, J.-S., Yu, W., Yamamoto, T., Kosaka, K., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1549-07.2007 · Cited by 186 · see citing works
β ‐Amyloid Degradation and Alzheimer′s Disease
Wang, D.-S., Dickson, D. W., & Malter, J. S. (2006) · BioMed Research International · doi:10.1155/jbb/2006/58406 · Cited by 185 · see citing works
Is inhibition of the renin–angiotensin system a new treatment option for Alzheimer's disease?
Kehoe, P. G., & Wilcock, G. K. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70077-7 · Cited by 180 · see citing works
Self-citationEckman, E. A., Adams, S. K., Troendle, F. J., Stodola, B. A., Kahn, M. A., Fauq, A. H., Xiao, H. D., Bernstein, K. E., & Eckman, C. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605827200 · Cited by 196 · see citing works
Miners, J. S., Ashby, E., Helmond, Z. V., Chalmers, K. A., Palmer, L. E., Love, S., & Kehoe, P. G. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00885.x · Cited by 165 · see citing works
Self-citationAngiotensins in Alzheimer's disease – friend or foe?
Kehoe, P. G., Miners, J. S., & Love, S. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.07.006 · Cited by 166 · see citing works
Self-citation(2009) · PubMed Central · Cited by 165 · see citing works
Self-citationTwo rare <i>AKAP9</i> variants are associated with Alzheimer's disease in African Americans
Logue, M. W., Schu, M., Vardarajan, B. N., Farrell, J., Bennett, D. A., Buxbaum, J. D., Byrd, G. S., Ertekin‐Taner, N., Evans, D., Foroud, T., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.06.010 · Cited by 136 · see citing works
Miners, J. S., Helmond, Z. V., Chalmers, K. A., Wilcock, G. K., Love, S., & Kehoe, P. G. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240463.87886.9a · Cited by 153 · see citing works
Self-citationKehoe, P. G. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-171119 · Cited by 133 · see citing works
Self-citationGenetic association studies in patients with traumatic brain injury
Dardiotis, E., Fountas, K. N., Dardioti, M., Xiromerisiou, G., Kapsalaki, E. Z., Τάσιου, Α., & Hadjigeorgiou, G. M. (2009) · Neurosurgical FOCUS · doi:10.3171/2009.10.focus09215 · Cited by 130 · see citing works
Fournier, A. E., Oprisiu, R., Sérot, J., Godefroy, O., Achard, J., Faure, S., Mazouz, H., Temmar, M., Albu, A., Bordet, R., et al. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.89 · Cited by 129 · see citing works
Zintzaras, E. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.10.1077 · Cited by 122 · see citing works
Bernstein, K. E., Koronyo, Y., Salumbides, B. C., Sheyn, J., Pelissier, L., Lopes, D. H. J., Shah, K. H., Bernstein, E. A., Fuchs, D.-T. S., Yu, J. J.-Y., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66541 · Cited by 117 · see citing works
Hemming, M. L., Selkoe, D., & Farris, W. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.01.004 · Cited by 126 · see citing works
Pharmacogenomics in Alzheimer's Disease
Cacabelos, R. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-205-2_10 · Cited by 109 · see citing works
Gouveia, F., Camins, A., Ettcheto, M., Bicker, J., Falcão, A. C., Cruz, M. T., & Fortuna, A. C. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101612 · Cited by 96 · see citing works
Gene therapy in Alzheimer’s disease – potential for disease modification
Nilsson, P., Iwata, N., Muramatsu, S., Tjernberg, L. O., Winblad, B. G., & Saido, T. C. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01038.x · Cited by 96 · see citing works
Ellul, J., Archer, N. J., Foy, C. M. L., Poppe, M., Boothby, H., Nicholas, H., Brown, R. G., & Lovestone, S. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.104034 · Cited by 91 · see citing works
Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia
Gao, Y., Ó’Caoimh, R., Healy, L. O., Kerins, D. M., Eustace, J. A., Guyatt, G. H., Sammon, D., & Molloy, D. W. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002881 · Cited by 85 · see citing works
Ó’Caoimh, R., Healy, L. O., Gao, Y., Svendrovski, A., Kerins, D. M., Eustace, J. A., Kehoe, P. G., Guyatt, G. H., & Molloy, D. W. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131694 · Cited by 80 · see citing works
Self-citationThe association of angiotensin-converting enzyme with biomarkers for Alzheimer’s disease
Jochemsen, H. M., Teunissen, C. E., Ashby, E. L., van der Flier, W. M., Jones, R. E., Geerlings, M. I., Scheltens, P., Kehoe, P. G., & Muller, M. (2014) · Alzheimer's Research & Therapy · doi:10.1186/alzrt257 · Cited by 77 · see citing works
Self-citationZou, K., Maeda, T., Watanabe, A., Liu, J., Liu, S., Oba, R., Satoh, Y.-I., Komano, H., & Michikawa, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.011437 · Cited by 76 · see citing works
Insights into the pathogenesis and pathogenicity of cerebral amyloid angiopathy
Love, S. (2009) · Frontiers in bioscience · doi:10.2741/3567 · Cited by 75 · see citing works
Meng, Y., Baldwin, C. T., Bowirrat, A., Waraska, K., Inzelberg, R., Friedland, R. P., & Farrer, L. A. (2006) · The American Journal of Human Genetics · doi:10.1086/503687 · Cited by 72 · see citing works
Toropygin, I. Y., Kugaevskaya, E. V., Mirgorodskaya, O. A., Elisseeva, Y. E., Kozmin, Y., Popov, I. A., Николаев, Е. Н., Makarov, A. А., & Kozin, S. A. (2007) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3357 · Cited by 72 · see citing works
Koronyo‐Hamaoui, M., Sheyn, J., Hayden, E. Y., Li, S., Fuchs, D.-T. S., Regis, G. C., Lopes, D. H. J., Black, K. L., Bernstein, K. E., Teplow, D. B., et al. (2019) · Brain · doi:10.1093/brain/awz364 · Cited by 70 · see citing works
Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants
Ukraintseva, S. V., Yashin, A. I., Arbeev, K. G., Kulminski, A. M., Akushevich, I. V., Wu, D., Joshi, G., Land, K. C., & Stallard, E. (2015) · Biogerontology · doi:10.1007/s10522-015-9600-1 · Cited by 67 · see citing works
Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project
Lehmann, D. J., Schuur, M., Warden, D. R., Hammond, N., Belbin, O., Kölsch, H., Lehmann, M. G., Wilcock, G. K., Brown, K. S., Kehoe, P. G., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.07.018 · Cited by 63 · see citing works
Self-citationAncelin, M., Carrière, I., Scali, J., Ritchie, K. A., Chaudieu, I., & Ryan, J. L. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.95 · Cited by 62 · see citing works
Combarros, O., Warden, D. R., Hammond, N., Cortina‐Borja, M., Belbin, O., Lehmann, M. G., Wilcock, G. K., Brown, K. S., Kehoe, P. G., Barber, R., et al. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-162 · Cited by 58 · see citing works
Self-citationLiu, S., Ando, F., Fujita, Y., Liu, J., Maeda, T., Shen, X., Kikuchi, K., Matsumoto, A., Yokomori, M., Tanabe, C., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006420 · Cited by 55 · see citing works
Masuyer, G., Yates, C. J., Sturrock, E. D., & Acharya, K. R. (2014) · Biological Chemistry · doi:10.1515/hsz-2014-0157 · Cited by 55 · see citing works
Carnovale, C., Perrotta, C., Baldelli, S., Cattaneo, D., Montrasio, C., Barbieri, S. S., Pompilio, G., Vantaggiato, C., Clementi, E., & Pozzi, M. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac110 · Cited by 54 · see citing works
Hajjar, I. M., Keown, M., Lewis, P., & Almor, A. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507309803 · Cited by 52 · see citing works
Ribeiro, V. T., de Souza, L. C., & Silva, A. C. S. E. (2019) · Protein and Peptide Letters · doi:10.2174/0929866527666191230103739 · Cited by 50 · see citing works
A Pilot Study of Gene/Gene and Gene/Environment Interactions in Alzheimer Disease
Ghebranious, N., Mukesh, B. N., Giampietro, P. F., Glurich, I., Mickel, S. F., Waring, S. C., & McCarty, C. A. (2010) · Clinical Medicine & Research · doi:10.3121/cmr.2010.894 · Cited by 50 · see citing works
Towards compendia of negative genetic association studies: an example for Alzheimer disease
Blomqvist, M. E.-L., Reynolds, C. A., Katzov, H., Feuk, L., Andreasen, N., Bogdanović, N., Blennow, K., Brookes, A. J., & Prince, J. A. (2005) · Human Genetics · doi:10.1007/s00439-005-0078-9 · Cited by 47 · see citing works
Self-citationEffects of age, genes, and pulse pressure on executive functions in healthy adults
Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., & Land, S. J. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.015 · Cited by 47 · see citing works
Zou, K., Liu, J., Watanabe, A., Hiraga, S., Liu, S., Tanabe, C., Maeda, T., Terayama, Y., Takahashi, S., Michikawa, M., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.01.053 · Cited by 47 · see citing works
Association between Chronic Blood Pressure Changes and Development of Alzheimer's Disease
Feldstein, C. A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120613 · Cited by 46 · see citing works
Rygiel, K. (2016) · Journal of Postgraduate Medicine · doi:10.4103/0022-3859.188553 · Cited by 45 · see citing works
Program, T. V. M. V., Bone, W. P., Siewert, K. M., Jha, A., Klarin, D., Damrauer, S. M., Chang, K.-M., Tsao, P. S., Assimes, T. L., Ritchie, M. D., et al. (2021) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00773-z · Cited by 41 · see citing works
“, the ALU insertion/deletion at the ACE locus) [32].”
BackgroundAβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes
Miners, J. S., Palmer, J. C., Tayler, H. M., Palmer, L. E., Ashby, E. L., Kehoe, P. G., & Love, S. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00238 · Cited by 41 · see citing works
Self-citationLe, D. D., Brown, L., Malik, K., & Murakami, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413178 · Cited by 41 · see citing works
The Beneficial Role of Vitamin D in Alzheimer’s Disease
Lương, K. V. Q., & Nguyễn, L. (2011) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317511429321 · Cited by 40 · see citing works
Ancillary risk information and pharmacogenetic tests: social and policy implications
Henrikson, N. B., Burke, W., & Veenstra, D. L. (2007) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500457 · Cited by 40 · see citing works
Functional regulation of Alu element of human angiotensin-converting enzyme gene in neuron cells
Wu, S.-J., Hsieh, T., Kuo, M., Tsai, M.-L., Tsai, K.-L., Chen, C., & Yang, Y. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.003 · Cited by 38 · see citing works
Edwards, T. L., Pericak‐Vance, M. A., Gilbert, J. R., Haines, J. L., Martin, E. R., & Ritchie, M. D. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30899 · Cited by 39 · see citing works
Biobanking for Epidemiological Research and Public Health
Brand, A. M., & Probst-Hensch, N. M. (2007) · Pathobiology · doi:10.1159/000104450 · Cited by 37 · see citing works
Kehoe, P. G., Blair, P. S., Howden, B., Thomas, D. L., Malone, I. B., Horwood, J., Clement, C., Selman, L. E., Baber, H., Lane, A., et al. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-170101 · Cited by 35 · see citing works
Self-citationWang, B., Jin, F., Yang, Z., Lu, Z., Kan, R., Li, S., Zheng, C., & Wang, L. (2006) · Journal of Molecular Neuroscience · doi:10.1385/jmn:30:3:267 · Cited by 36 · see citing works
Angiotensins and Alzheimer's disease: a bench to bedside overview
Kehoe, P. G. (2009) · Alzheimer s Research & Therapy · doi:10.1186/alzrt3 · Cited by 35 · see citing works
Self-citationRenin Angiotensin Aldosterone System Inhibition in Controlling Dementia-Related Cognitive Decline
Ó’Caoimh, R., Kehoe, P. G., & Molloy, D. W. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141284 · Cited by 35 · see citing works
Self-citationKunkle, B., Grenier-Boley, B., Sims, R., Bis, J., Naj, A., Boland, A., Vronskaya, M., van der Lee, S., Amlie-Wolf, A., Bellenguez, C., et al. (2018) · doi:10.1101/294629 · Cited by 35 · see citing works
Self-citationEny, K. M., Corey, P., & El‐Sohemy, A. (2009) · Lifestyle Genomics · doi:10.1159/000276991 · Cited by 34 · see citing works
Lucatelli, J. F., Barros, A. C., da Silva, V. K., MACHADO, F. D. S., Constantin, P. C., Dias, A., Hutz, M. H., & de Andrade, F. M. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0481-7 · Cited by 34 · see citing works
The Role of Beta-Adrenergic Receptor Blockers in Alzheimer’s Disease
Lương, K. V. Q., & Nguyễn, L. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317513488924 · Cited by 32 · see citing works
Acute Myocardial Infarction and Risk of Cognitive Impairment and Dementia: A Review
Thong, E. H., Quek, J. W. E., Loo, J. H., Yun, C.-Y., Teo, Y. N., Teo, Y. H., Leow, A. S., Li, T. Y., Sharma, V. K., Tan, B. Y., et al. (2023) · Biology · doi:10.3390/biology12081154 · Cited by 31 · see citing works
Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia
Mohite, S., de Campos-Carli, S. M., Rocha, N. P., Sharma, S., de Miranda, A. S., Barbosa, I. G., Salgado, J. V., Silva, A. C. S. E., & Teixeira, A. L. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.06.023 · Cited by 31 · see citing works
Sherva, R., & Farrer, L. A. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0184-4 · Cited by 31 · see citing works
Alhenc‐Gelas, F., Bouby, N., & Girolami, J. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00136 · Cited by 30 · see citing works
Angiotensin‐converting enzymes as druggable features of psychiatric and neurodegenerative disorders
Santiago, T. C., Parra, L., Nani, J. V. S., Fidalgo, T. M., Bradshaw, N. J., & Hayashi, M. A. F. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15806 · Cited by 30 · see citing works
Nacmias, B., Bagnoli, S., Tedde, A., Cellini, E., Bessi, V., Guarnieri, B., Ortensi, L., Piacentini, S., Bracco, L., & Sorbi, S. (2006) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2006.10.011 · Cited by 30 · see citing works
Jenkins, T. A., & Chai, S. Y. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.08.010 · Cited by 29 · see citing works
Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer’s disease
Yokoyama, J. S., Bonham, L. W., Sears, R. L., Klein, E., Karydas, A., Kramer, J. H., Miller, B. L., & Coppola, G. (2015) · BMC Neurology · doi:10.1186/s12883-015-0304-6 · Cited by 28 · see citing works
Of mice and men: more neurobiology in dementia
Codita, A., Winblad, B. G., & Mohammed, A. H. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000245757.06374.6a · Cited by 28 · see citing works
Abdollahi, M. R., Huang, S., Rodrı́guez, S., Guthrie, P. A. I., Smith, G. D., Ebrahim, S. B. J., Lawlor, D. A., Day, I. N. M., & Gaunt, T. R. (2007) · Disease Markers · doi:10.1155/2008/813679 · Cited by 28 · see citing works
Alzheimer’s Disease Genetics: Review of Novel Loci Associated with Disease
Tábuas‐Pereira, M., Santana, I. J., Guerreiro, R. J., & Brás, J. (2020) · Current Genetic Medicine Reports · doi:10.1007/s40142-020-00182-y · Cited by 26 · see citing works
Zou, K., & Michikawa, M. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.4-5.203 · Cited by 27 · see citing works
Lipoproteins, Vascular-Related Genetic Factors, and Human Longevity
Panza, F., D’Introno, A., Capurso, C. A., Colacicco, A. M., Seripa, D., Pilotto, A., Santamato, A., Capurso, A., & Solfrizzi, V. (2007) · Rejuvenation Research · doi:10.1089/rej.2007.0537 · Cited by 27 · see citing works
Chung, C., Wang, R.-Y., Fann, C. S. J., Chen, J., Jong, Y.-S., Jou, Y., Yang, H., Kang, C.-S., Chen, C., Chang, H.-C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056119 · Cited by 26 · see citing works
An age effect on the association of common variants of ACE with Alzheimer's disease
Helbecque, N., Codron, V., Cottel, D., & Amouyel, P. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.06.006 · Cited by 26 · see citing works
Purandare, N. B., Voshaar, R. C. O., Davidson, Y. S., Gibbons, L., Hardicre, J., Byrne, E. J., McCollum, C. N., Jackson, A., Burns, A. S., & Mann, D. M. A. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00841.x · Cited by 26 · see citing works
Akatsu, H., Ogawa, N., Kanesaka, T., Hori, A., Yamamoto, T., Matsukawa, N., & Michikawa, M. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.09.030 · Cited by 24 · see citing works
Cognitive disorders in diabetic patients
Koekkoek, P. S., Rutten, G. E. H. M., & Biessels, G. J. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53480-4.00011-4 · Cited by 24 · see citing works
Janssens, A. C. J. W., & Khoury, M. J. (2006) · Italian Journal of Public Health · doi:10.2427/5915 · Cited by 23 · see citing works
Zhang, Z., Yang, N., Zhao, G., Zhu, L., & Wang, L.-X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030551 · Cited by 22 · see citing works
Literature-related discovery: common factors for Parkinson’s Disease and Crohn’s Disease
Kostoff, R. N. (2014) · Scientometrics · doi:10.1007/s11192-014-1298-3 · Cited by 21 · see citing works
PSEN1 polymorphisms alter the rate of cognitive decline in sporadic Alzheimer's disease patients
Belbin, O., Beaumont, H., Warden, D. R., Smith, A. D., Kalsheker, N. A., & Morgan, K. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.02.013 · Cited by 21 · see citing works
Self-citationInteraction of insulin and PPAR-α genes in Alzheimer’s disease: the Epistasis Project
Kölsch, H., Lehmann, D. J., Ibrahim‐Verbaas, C. A., Combarros, O., van Duijn, C. M., Hammond, N., Belbin, O., Cortina‐Borja, M., Lehmann, M. G., Aulchenko, Y. S., et al. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0732-4 · Cited by 21 · see citing works
Self-citationQin, X. Y., Peng, Q., Zeng, Z., Chen, Z., Lin, L., Deng, Y., Huang, X., Xu, J., Wu, H., Huang, S., et al. (2012) · Journal of Neurology · doi:10.1007/s00415-011-6381-6 · Cited by 20 · see citing works
Gustafson, D., Melchior, L. C., Eriksson, E., Sundh, V., Blennow, K., & Skoog, I. G. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.07.015 · Cited by 20 · see citing works
Zhang, Z., Deng, L., Yu, H., Shi, Y., Bai, F., Xie, C., Yuan, Y., Jia, J., & Zhang, Z. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.02.074 · Cited by 19 · see citing works
Zhang, Z., Deng, L., Bai, F., Shi, Y., Yu, H., Yuan, Y., Jiang, T., Jia, J., & Zhang, Z. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.032 · Cited by 19 · see citing works
Unknown face of known drugs – what else can we expect from angiotensin converting enzyme inhibitors?
Wzgarda, A., Kleszcz, R., Prokop-Piotrkowska, M., Regulska, K., Regulski, M., Paluszczak, J., & Stanisz, B. J. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.12.031 · Cited by 19 · see citing works
- Authors
- Lehmann, D. J., Cortina-Borja, M., Warden, D. R., Smith, A. D., Sleegers, K., Prince, J. A., van Duijn, C. M., & Kehoe, P. G.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Lehmann, Donald J.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-08-15
- Volume
- 162
- Issue
- 4
- Pages
- 305-317
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2044936845
- Cited by
- 199
- References
- 79
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 8 · 2022: 3 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 9 · 2016: 5 · 2015: 7 · 2014: 15 · 2013: 9 · 2012: 9
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- Alzheimer's disease, angiotensin-converting enzyme, ACE I/D polymorphism, APOE ε4, genetic susceptibility, genetic association, linkage disequilibrium, heterosis, ethnic differences, Hardy-Weinberg equilibrium, risk factors
- MeSH terms
- Aged, Alzheimer Disease, Apolipoproteins E, Ethnicity, Female, Humans, Hybrid Vigor, Peptidyl-Dipeptidase A, Male, Middle Aged, Polymorphism, Genetic, Confidence Intervals, Apolipoprotein E4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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