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Pulmonary Surfactant Therapy
Abstract
In 1959, not long after surfactant had been identified as critical to maintaining lung inflation at low transpulmonary pressures,1,2 Avery and Mead3 reported that saline extracts from the lungs of preterm infants with respiratory distress syndrome lacked the low surface tension characteristic of pulmonary surfactant. After several unsuccessful attempts to treat infants with respiratory distress syndrome with aerosolized surfactant,4,5 intratracheal administration of surfactant recovered from the air spaces of mature animal lungs was found to improve lung expansion and ventilation in preterm animals68. The clinical potential of surfactant treatment for respiratory distress syndrome was demonstrated by . . .
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Citations
Cited by
Immunoregulatory functions of surfactant proteins
Wright, J. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1528 · Cited by 964
Donovan, J., Little, P., Mills, N., Smith, M., Brindle, L., Jacoby, A., Peters, T., Frankel, S., Neal, D., & Hamdy, F. (2002) · BMJ · doi:10.1136/bmj.325.7367.766 · Cited by 533
Verder, H., Robertson, B., Greisen, G., Ebbesen, F., Albertsen, P., Lundstrom, K., & Jacobsen, T. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311603 · Cited by 448
Willson, D. F. (2005) · JAMA · doi:10.1001/jama.293.4.470 · Cited by 420
Romaní-Pérez, M., Outeiriño-Iglesias, V., Gil-Lozano, M., González-Matías, L. C., Mallo, F., & Vigo, E. (2013) · Endocrinology · doi:10.1210/en.2012-1786 · Cited by 51
Metadata
- Authors
- Wood, A. J. J., & Jobe, A. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1993-03-25
- Volume
- 328
- Issue
- 12
- Pages
- 861-868
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2335075431
- Cited by
- 666
- References
- 0
- FWCI
- 36.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pulmonary Surfactant Therapy. https://app.cochat.ai/papers/10.1056/nejm199303253281208
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- Wood, A. J. J., & Jobe, A. H. (1993). Pulmonary Surfactant Therapy. New England Journal of Medicine. https://doi.org/10.1056/nejm199303253281208
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
